eF-site ID 6giv-A PDB Code 6giv Chain A click to enlarge Title Structure of GluA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and Rubidium Bromide at 1.75 A resolution Classification MEMBRANE PROTEIN Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence A:  GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLA AEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTP IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT YMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLK LSEQGLLDKLKNKWWYDKGECG Description Functional site 1) chain A residue 61 type sequence Y description binding site for residue GLU A 301 source : AC1 2) chain A residue 89 type sequence P description binding site for residue GLU A 301 source : AC1 3) chain A residue 90 type sequence L description binding site for residue GLU A 301 source : AC1 4) chain A residue 91 type sequence T description binding site for residue GLU A 301 source : AC1 5) chain A residue 96 type sequence R description binding site for residue GLU A 301 source : AC1 6) chain A residue 141 type sequence G description binding site for residue GLU A 301 source : AC1 7) chain A residue 142 type sequence S description binding site for residue GLU A 301 source : AC1 8) chain A residue 143 type sequence T description binding site for residue GLU A 301 source : AC1 9) chain A residue 193 type sequence E description binding site for residue GLU A 301 source : AC1 10) chain A residue 220 type sequence Y description binding site for residue GLU A 301 source : AC1 11) chain A residue 140 type sequence S description binding site for residue SO4 A 302 source : AC2 12) chain A residue 144 type sequence K description binding site for residue SO4 A 302 source : AC2 13) chain A residue 148 type sequence R description binding site for residue SO4 A 302 source : AC2 14) chain A residue 214 type sequence N description binding site for residue GOL A 303 source : AC3 15) chain A residue 216 type sequence D description binding site for residue GOL A 303 source : AC3 16) chain A residue 217 type sequence S description binding site for residue GOL A 303 source : AC3 17) chain A residue 248 type sequence D description binding site for residue GOL A 303 source : AC3 18) chain A residue 21 type sequence K description binding site for residue GOL A 304 source : AC4 19) chain A residue 31 type sequence R description binding site for residue GOL A 304 source : AC4 20) chain A residue 52 type sequence K description binding site for residue GOL A 304 source : AC4 21) chain A residue 148 type sequence R description binding site for residue GOL A 305 source : AC5 22) chain A residue 159 type sequence W description binding site for residue GOL A 305 source : AC5 23) chain A residue 163 type sequence R description binding site for residue GOL A 305 source : AC5 24) chain A residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 61 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 89 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 28) chain A residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 32) chain A residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI5 35) chain A residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI6 36) chain A residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI7 37) chain A residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8

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