eF-site ID 6gis-ABC PDB Code 6gis Chain A, B, C click to enlarge Title Structural basis of human clamp sliding on DNA Classification DNA BINDING PROTEIN Compound Proliferating cell nuclear antigen Source (6GIS) Sequence A:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI SCAKDGVKFSASGELGNGNIKLSQTEEAVTIEMNEPVQLT FALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGH LKYYLAPK B:  HMFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQS MDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKIL KCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLM DLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVV ISCAKDGVKFSASGELGNGNIKLSQTEEEAVTIEMNEPVQ LTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADM GHLKYYLAPK C:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI SCAKDGVKFSASGELGNGNIKLSQTEAVTIEMNEPVQLTF ALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHL KYYLAP Description Functional site 1) chain A residue 254 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 2) chain B residue 254 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 3) chain A residue 61-80 type DNA_BIND sequence RCDRNLAMGVNLTSMSKILK description DNA_BIND => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 61-80 type DNA_BIND sequence RCDRNLAMGVNLTSMSKILK description DNA_BIND => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain C residue 61-80 type DNA_BIND sequence RCDRNLAMGVNLTSMSKILK description DNA_BIND => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 14 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:19419956 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 14 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:19419956 source Swiss-Prot : SWS_FT_FI2 8) chain C residue 14 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:19419956 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 77 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 80 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 248 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 77 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 80 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 248 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 15) chain C residue 77 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 16) chain C residue 80 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 17) chain C residue 248 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 211 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032 source Swiss-Prot : SWS_FT_FI4 19) chain B residue 211 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032 source Swiss-Prot : SWS_FT_FI4 20) chain C residue 211 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 164 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289 source Swiss-Prot : SWS_FT_FI5 22) chain B residue 164 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289 source Swiss-Prot : SWS_FT_FI5 23) chain C residue 164 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289 source Swiss-Prot : SWS_FT_FI5 24) chain A residue 61-79 type prosite sequence RCDRNLAMGVNLTSMSKIL description PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL source prosite : PS00293 25) chain A residue 34-57 type prosite sequence GVNLQSMDSSHVSLVQLTLRSEGF description PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF source prosite : PS01251

Display surface Download Links