eF-site ID 6gis-A
PDB Code 6gis
Chain A

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Title Structural basis of human clamp sliding on DNA
Classification DNA BINDING PROTEIN
Compound Proliferating cell nuclear antigen
Source (6GIS)
Sequence A:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM
DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK
CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI
SCAKDGVKFSASGELGNGNIKLSQTEEAVTIEMNEPVQLT
FALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGH
LKYYLAPK
Description


Functional site

1) chain A
residue 254
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI6

2) chain A
residue 61-80
type DNA_BIND
sequence RCDRNLAMGVNLTSMSKILK
description DNA_BIND => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 14
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:19419956
source Swiss-Prot : SWS_FT_FI2

4) chain A
residue 77
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

5) chain A
residue 80
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

6) chain A
residue 248
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

7) chain A
residue 211
type MOD_RES
sequence Y
description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032
source Swiss-Prot : SWS_FT_FI4

8) chain A
residue 164
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289
source Swiss-Prot : SWS_FT_FI5

9) chain A
residue 61-79
type prosite
sequence RCDRNLAMGVNLTSMSKIL
description PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL
source prosite : PS00293

10) chain A
residue 34-57
type prosite
sequence GVNLQSMDSSHVSLVQLTLRSEGF
description PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF
source prosite : PS01251


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