eF-site ID 6ghk-B PDB Code 6ghk Chain B click to enlarge Title Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527 Classification TRANSFERASE Compound Poly [ADP-ribose] polymerase 1 Source (PARP1_HUMAN) Sequence B:  MKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGK LSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLI PHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRG GSSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTH ATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWH GSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVS KSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLP KGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDT SLLYNEYIVYDIAQVNLKYLLKLKFNFKTAHHHHH Description Functional site 1) chain B residue 798 type sequence K description binding site for residue SO4 A 1102 source : AC2 2) chain B residue 875 type sequence Q description binding site for residue SO4 A 1102 source : AC2 3) chain B residue 1012 type sequence A description binding site for residue SO4 A 1103 source : AC3 4) chain B residue 1013 type sequence H description binding site for residue SO4 A 1103 source : AC3 5) chain B residue 865 type sequence R description binding site for residue SO4 A 1104 source : AC4 6) chain B residue 906 type sequence N description binding site for residue SO4 A 1104 source : AC4 7) chain B residue 909 type sequence H description binding site for residue SO4 A 1104 source : AC4 8) chain B residue 1014 type sequence H description binding site for residue SO4 A 1105 source : AC5 9) chain B residue 1016 type sequence H description binding site for residue SO4 A 1105 source : AC5 10) chain B residue 710 type sequence Y description binding site for residue EZ2 B 1101 source : AC6 11) chain B residue 766 type sequence D description binding site for residue EZ2 B 1101 source : AC6 12) chain B residue 862 type sequence H description binding site for residue EZ2 B 1101 source : AC6 13) chain B residue 863 type sequence G description binding site for residue EZ2 B 1101 source : AC6 14) chain B residue 878 type sequence R description binding site for residue EZ2 B 1101 source : AC6 15) chain B residue 880 type sequence A description binding site for residue EZ2 B 1101 source : AC6 16) chain B residue 881 type sequence P description binding site for residue EZ2 B 1101 source : AC6 17) chain B residue 889 type sequence Y description binding site for residue EZ2 B 1101 source : AC6 18) chain B residue 894 type sequence G description binding site for residue EZ2 B 1101 source : AC6 19) chain B residue 896 type sequence Y description binding site for residue EZ2 B 1101 source : AC6 20) chain B residue 897 type sequence F description binding site for residue EZ2 B 1101 source : AC6 21) chain B residue 904 type sequence S description binding site for residue EZ2 B 1101 source : AC6 22) chain B residue 907 type sequence Y description binding site for residue EZ2 B 1101 source : AC6 23) chain B residue 988 type sequence E description binding site for residue EZ2 B 1101 source : AC6 24) chain B residue 702 type sequence S description binding site for residue SO4 B 1102 source : AC7 25) chain B residue 703 type sequence K description binding site for residue SO4 B 1102 source : AC7 26) chain B residue 704 type sequence R description binding site for residue SO4 B 1102 source : AC7 27) chain B residue 903 type sequence K description binding site for residue SO4 B 1103 source : AC8 28) chain B residue 984 type sequence L description binding site for residue SO4 B 1103 source : AC8 29) chain B residue 985 type sequence L description binding site for residue SO4 B 1103 source : AC8 30) chain B residue 986 type sequence Y description binding site for residue SO4 B 1103 source : AC8 31) chain B residue 988 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 862 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 871 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 878 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 904 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 782 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 786 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 38) chain B residue 748 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5

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