eF-site ID 6ggh-B PDB Code 6ggh Chain B click to enlarge Title Human jak1 kinase domain in complex with inhibitor Classification TRANSFERASE Compound Tyrosine-protein kinase JAK1 Source (JAK1_HUMAN) Sequence B:  TEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLGNHIADLKKEIEILRNLYHENIVKYKGICTGI KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMD YLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDK EXXTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLH ELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGK RLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL LK Description Functional site 1) chain B residue 881 type sequence L description binding site for residue EYQ B 1201 source : AC2 2) chain B residue 882 type sequence G description binding site for residue EYQ B 1201 source : AC2 3) chain B residue 906 type sequence A description binding site for residue EYQ B 1201 source : AC2 4) chain B residue 957 type sequence E description binding site for residue EYQ B 1201 source : AC2 5) chain B residue 958 type sequence F description binding site for residue EYQ B 1201 source : AC2 6) chain B residue 959 type sequence L description binding site for residue EYQ B 1201 source : AC2 7) chain B residue 960 type sequence P description binding site for residue EYQ B 1201 source : AC2 8) chain B residue 962 type sequence G description binding site for residue EYQ B 1201 source : AC2 9) chain B residue 966 type sequence E description binding site for residue EYQ B 1201 source : AC2 10) chain B residue 1003 type sequence D description binding site for residue EYQ B 1201 source : AC2 11) chain B residue 1007 type sequence R description binding site for residue EYQ B 1201 source : AC2 12) chain B residue 1008 type sequence N description binding site for residue EYQ B 1201 source : AC2 13) chain B residue 1010 type sequence L description binding site for residue EYQ B 1201 source : AC2 14) chain B residue 1020 type sequence G description binding site for residue EYQ B 1201 source : AC2 15) chain B residue 1021 type sequence D description binding site for residue EYQ B 1201 source : AC2 16) chain B residue 1042 type sequence D description binding site for residue EYQ B 1201 source : AC2 17) chain B residue 1034 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 1035 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529 source Swiss-Prot : SWS_FT_FI4 19) chain B residue 1003 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 881 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 908 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:32750333 source Swiss-Prot : SWS_FT_FI3

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