eF-site ID 6ggh-A
PDB Code 6ggh
Chain A

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Title Human jak1 kinase domain in complex with inhibitor
Classification TRANSFERASE
Compound Tyrosine-protein kinase JAK1
Source (JAK1_HUMAN)
Sequence A:  VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQ
VAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGIC
TNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQIC
KGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAI
ETDKEXXTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFG
VTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTL
KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEG
FEALLK
Description


Functional site

1) chain A
residue 881
type
sequence L
description binding site for residue EYQ A 1201
source : AC1

2) chain A
residue 882
type
sequence G
description binding site for residue EYQ A 1201
source : AC1

3) chain A
residue 889
type
sequence V
description binding site for residue EYQ A 1201
source : AC1

4) chain A
residue 906
type
sequence A
description binding site for residue EYQ A 1201
source : AC1

5) chain A
residue 957
type
sequence E
description binding site for residue EYQ A 1201
source : AC1

6) chain A
residue 958
type
sequence F
description binding site for residue EYQ A 1201
source : AC1

7) chain A
residue 959
type
sequence L
description binding site for residue EYQ A 1201
source : AC1

8) chain A
residue 960
type
sequence P
description binding site for residue EYQ A 1201
source : AC1

9) chain A
residue 962
type
sequence G
description binding site for residue EYQ A 1201
source : AC1

10) chain A
residue 966
type
sequence E
description binding site for residue EYQ A 1201
source : AC1

11) chain A
residue 1003
type
sequence D
description binding site for residue EYQ A 1201
source : AC1

12) chain A
residue 1007
type
sequence R
description binding site for residue EYQ A 1201
source : AC1

13) chain A
residue 1008
type
sequence N
description binding site for residue EYQ A 1201
source : AC1

14) chain A
residue 1010
type
sequence L
description binding site for residue EYQ A 1201
source : AC1

15) chain A
residue 1020
type
sequence G
description binding site for residue EYQ A 1201
source : AC1

16) chain A
residue 1021
type
sequence D
description binding site for residue EYQ A 1201
source : AC1

17) chain A
residue 881-908
type prosite
sequence LGEGHFGKVELCRYDPEGDNTGEQVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGHFGKVElCrydpegdntgeq......VAVK
source prosite : PS00107

18) chain A
residue 999-1011
type prosite
sequence YVHRDLAARNVLV
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNVLV
source prosite : PS00109

19) chain A
residue 1003
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 881
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 908
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:32750333
source Swiss-Prot : SWS_FT_FI3

22) chain A
residue 1034
type MOD_RES
sequence X
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529
source Swiss-Prot : SWS_FT_FI4

23) chain A
residue 1035
type MOD_RES
sequence X
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529
source Swiss-Prot : SWS_FT_FI4


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