eF-site ID 6ggf-B PDB Code 6ggf Chain B click to enlarge Title Structure of the p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9328 Classification DNA BINDING PROTEIN Compound Cellular tumor antigen p53 Source (P53_HUMAN) Sequence B:  SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKL FCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV RRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFR HSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILT IITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK Description Functional site 1) chain B residue 176 type sequence C description binding site for residue ZN B 401 source : AC3 2) chain B residue 179 type sequence H description binding site for residue ZN B 401 source : AC3 3) chain B residue 238 type sequence C description binding site for residue ZN B 401 source : AC3 4) chain B residue 242 type sequence C description binding site for residue ZN B 401 source : AC3 5) chain B residue 145 type sequence L description binding site for residue EXQ B 402 source : AC4 6) chain B residue 147 type sequence V description binding site for residue EXQ B 402 source : AC4 7) chain B residue 150 type sequence T description binding site for residue EXQ B 402 source : AC4 8) chain B residue 220 type sequence C description binding site for residue EXQ B 402 source : AC4 9) chain B residue 221 type sequence E description binding site for residue EXQ B 402 source : AC4 10) chain B residue 222 type sequence P description binding site for residue EXQ B 402 source : AC4 11) chain B residue 223 type sequence P description binding site for residue EXQ B 402 source : AC4 12) chain B residue 228 type sequence D description binding site for residue EXQ B 402 source : AC4 13) chain B residue 230 type sequence T description binding site for residue EXQ B 402 source : AC4 14) chain B residue 174 type sequence R description binding site for residue GOL B 403 source : AC5 15) chain B residue 192 type sequence Q description binding site for residue GOL B 403 source : AC5 16) chain B residue 193 type sequence H description binding site for residue GOL B 403 source : AC5 17) chain B residue 207 type sequence D description binding site for residue GOL B 403 source : AC5 18) chain B residue 212 type sequence F description binding site for residue GOL B 403 source : AC5 19) chain B residue 214 type sequence H description binding site for residue GOL B 403 source : AC5 20) chain B residue 120 type MOD_RES sequence K description N6-acetyllysine; by KAT6A => ECO:0000269|PubMed:23431171 source Swiss-Prot : SWS_FT_FI4 21) chain B residue 183 type MOD_RES sequence S description Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI5 22) chain B residue 269 type MOD_RES sequence S description Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI5 23) chain B residue 284 type MOD_RES sequence T description Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI6 24) chain B residue 291 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 source Swiss-Prot : SWS_FT_FI8 25) chain B residue 176 type BINDING sequence C description BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 179 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 238 type BINDING sequence C description BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 242 type BINDING sequence C description BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 120 type SITE sequence K description Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 source Swiss-Prot : SWS_FT_FI3

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