eF-site ID 6gge-AB PDB Code 6gge Chain A, B click to enlarge Title p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327 Classification DNA BINDING PROTEIN Compound Cellular tumor antigen p53 Source (P53_HUMAN) Sequence A:  SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFC QLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRR CPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHS VVVPCEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILTII TLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKK B:  SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKL FCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV RRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFR HSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILT IITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK Description Functional site 1) chain A residue 176 type sequence C description binding site for residue ZN A 401 source : AC1 2) chain A residue 179 type sequence H description binding site for residue ZN A 401 source : AC1 3) chain A residue 238 type sequence C description binding site for residue ZN A 401 source : AC1 4) chain A residue 242 type sequence C description binding site for residue ZN A 401 source : AC1 5) chain A residue 145 type sequence L description binding site for residue EYE A 402 source : AC2 6) chain A residue 147 type sequence V description binding site for residue EYE A 402 source : AC2 7) chain A residue 150 type sequence T description binding site for residue EYE A 402 source : AC2 8) chain A residue 220 type sequence C description binding site for residue EYE A 402 source : AC2 9) chain A residue 221 type sequence E description binding site for residue EYE A 402 source : AC2 10) chain A residue 222 type sequence P description binding site for residue EYE A 402 source : AC2 11) chain A residue 223 type sequence P description binding site for residue EYE A 402 source : AC2 12) chain A residue 228 type sequence D description binding site for residue EYE A 402 source : AC2 13) chain A residue 230 type sequence T description binding site for residue EYE A 402 source : AC2 14) chain B residue 176 type sequence C description binding site for residue ZN B 401 source : AC3 15) chain B residue 179 type sequence H description binding site for residue ZN B 401 source : AC3 16) chain B residue 238 type sequence C description binding site for residue ZN B 401 source : AC3 17) chain B residue 242 type sequence C description binding site for residue ZN B 401 source : AC3 18) chain B residue 145 type sequence L description binding site for residue EYE B 402 source : AC4 19) chain B residue 147 type sequence V description binding site for residue EYE B 402 source : AC4 20) chain B residue 150 type sequence T description binding site for residue EYE B 402 source : AC4 21) chain B residue 151 type sequence P description binding site for residue EYE B 402 source : AC4 22) chain B residue 152 type sequence P description binding site for residue EYE B 402 source : AC4 23) chain B residue 153 type sequence P description binding site for residue EYE B 402 source : AC4 24) chain B residue 220 type sequence C description binding site for residue EYE B 402 source : AC4 25) chain B residue 221 type sequence E description binding site for residue EYE B 402 source : AC4 26) chain B residue 222 type sequence P description binding site for residue EYE B 402 source : AC4 27) chain B residue 223 type sequence P description binding site for residue EYE B 402 source : AC4 28) chain B residue 228 type sequence D description binding site for residue EYE B 402 source : AC4 29) chain B residue 230 type sequence T description binding site for residue EYE B 402 source : AC4

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