eF-site ID 6ggd-B
PDB Code 6ggd
Chain B

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Title p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324
Classification DNA BINDING PROTEIN
Compound Cellular tumor antigen p53
Source (P53_HUMAN)
Sequence B:  SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKL
FCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV
RRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFR
HSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILT
IITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK
Description (1)  Cellular tumor antigen p53


Functional site

1) chain B
residue 176
type
ligand
sequence C
description binding site for residue ZN B 401
source : AC3

2) chain B
residue 179
type
ligand
sequence H
description binding site for residue ZN B 401
source : AC3

3) chain B
residue 238
type
ligand
sequence C
description binding site for residue ZN B 401
source : AC3

4) chain B
residue 242
type
ligand
sequence C
description binding site for residue ZN B 401
source : AC3

5) chain B
residue 145
type
ligand
sequence L
description binding site for residue EYB B 402
source : AC4

6) chain B
residue 147
type
ligand
sequence V
description binding site for residue EYB B 402
source : AC4

7) chain B
residue 150
type
ligand
sequence T
description binding site for residue EYB B 402
source : AC4

8) chain B
residue 151
type
ligand
sequence P
description binding site for residue EYB B 402
source : AC4

9) chain B
residue 220
type
ligand
sequence C
description binding site for residue EYB B 402
source : AC4

10) chain B
residue 221
type
ligand
sequence E
description binding site for residue EYB B 402
source : AC4

11) chain B
residue 222
type
ligand
sequence P
description binding site for residue EYB B 402
source : AC4

12) chain B
residue 223
type
ligand
sequence P
description binding site for residue EYB B 402
source : AC4

13) chain B
residue 228
type
ligand
sequence D
description binding site for residue EYB B 402
source : AC4

14) chain B
residue 230
type
ligand
sequence T
description binding site for residue EYB B 402
source : AC4

15) chain B
residue 174
type
ligand
sequence R
description binding site for residue GOL B 403
source : AC5

16) chain B
residue 192
type
ligand
sequence Q
description binding site for residue GOL B 403
source : AC5

17) chain B
residue 207
type
ligand
sequence D
description binding site for residue GOL B 403
source : AC5

18) chain B
residue 212
type
ligand
sequence F
description binding site for residue GOL B 403
source : AC5

19) chain B
residue 214
type
ligand
sequence H
description binding site for residue GOL B 403
source : AC5

20) chain B
residue 145-147
type binding
ligand EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
sequence LWV
description [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium binding site
source pdb_hetatom : EYB_6ggd_B_402

21) chain B
residue 150-155
type binding
ligand EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
sequence TPPPGT
description [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium binding site
source pdb_hetatom : EYB_6ggd_B_402

22) chain B
residue 220-223
type binding
ligand EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
sequence CEPP
description [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium binding site
source pdb_hetatom : EYB_6ggd_B_402

23) chain B
residue 228-230
type binding
ligand EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
sequence DCT
description [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium binding site
source pdb_hetatom : EYB_6ggd_B_402

24) chain B
residue 172
type binding
ligand GOL: GLYCEROL
sequence V
description GLYCEROL binding site
source pdb_hetatom : GOL_6ggd_B_403

25) chain B
residue 174
type binding
ligand GOL: GLYCEROL
sequence R
description GLYCEROL binding site
source pdb_hetatom : GOL_6ggd_B_403

26) chain B
residue 192
type binding
ligand GOL: GLYCEROL
sequence Q
description GLYCEROL binding site
source pdb_hetatom : GOL_6ggd_B_403

27) chain B
residue 207-208
type binding
ligand GOL: GLYCEROL
sequence DD
description GLYCEROL binding site
source pdb_hetatom : GOL_6ggd_B_403

28) chain B
residue 212-214
type binding
ligand GOL: GLYCEROL
sequence FRH
description GLYCEROL binding site
source pdb_hetatom : GOL_6ggd_B_403


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