eF-site ID 6ggd-B
PDB Code 6ggd
Chain B

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Title p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324
Classification DNA BINDING PROTEIN
Compound Cellular tumor antigen p53
Source (P53_HUMAN)
Sequence B:  SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKL
FCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV
RRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFR
HSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILT
IITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK
Description (1)  Cellular tumor antigen p53


Functional site

1) chain B
residue 176
type
ligand
sequence C
description binding site for residue ZN B 401
source : AC3

2) chain B
residue 179
type
ligand
sequence H
description binding site for residue ZN B 401
source : AC3

3) chain B
residue 238
type
ligand
sequence C
description binding site for residue ZN B 401
source : AC3

4) chain B
residue 242
type
ligand
sequence C
description binding site for residue ZN B 401
source : AC3

5) chain B
residue 145
type
ligand
sequence L
description binding site for residue EYB B 402
source : AC4

6) chain B
residue 147
type
ligand
sequence V
description binding site for residue EYB B 402
source : AC4

7) chain B
residue 150
type
ligand
sequence T
description binding site for residue EYB B 402
source : AC4

8) chain B
residue 151
type
ligand
sequence P
description binding site for residue EYB B 402
source : AC4

9) chain B
residue 220
type
ligand
sequence C
description binding site for residue EYB B 402
source : AC4

10) chain B
residue 221
type
ligand
sequence E
description binding site for residue EYB B 402
source : AC4

11) chain B
residue 222
type
ligand
sequence P
description binding site for residue EYB B 402
source : AC4

12) chain B
residue 223
type
ligand
sequence P
description binding site for residue EYB B 402
source : AC4

13) chain B
residue 228
type
ligand
sequence D
description binding site for residue EYB B 402
source : AC4

14) chain B
residue 230
type
ligand
sequence T
description binding site for residue EYB B 402
source : AC4

15) chain B
residue 174
type
ligand
sequence R
description binding site for residue GOL B 403
source : AC5

16) chain B
residue 192
type
ligand
sequence Q
description binding site for residue GOL B 403
source : AC5

17) chain B
residue 207
type
ligand
sequence D
description binding site for residue GOL B 403
source : AC5

18) chain B
residue 212
type
ligand
sequence F
description binding site for residue GOL B 403
source : AC5

19) chain B
residue 214
type
ligand
sequence H
description binding site for residue GOL B 403
source : AC5


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