eF-site ID 6gff-ABCDEFGHIJKLMN PDB Code 6gff Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N click to enlarge Title Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab Classification IMMUNE SYSTEM Compound Transforming growth factor beta-1 Source ORGANISM_COMMON: Mouse; ORGANISM_SCIENTIFIC: Mus musculus; Sequence A:  LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP PGPLPEAVLALYNSTRDRVEPEADYYAKEVTRVLIYMFFN TSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQLSNR LLAPSDSPEWLSFDVTGVVRQWLSEGFRLSAHCSCNRPFL LLMATPLE B:  ALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYH ANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVP QALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS C:  TCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPG PLPEAVLALYNSTRDRVPEADYYAKEVTRVLMVETHNEIY DKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLK LKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVT GVVRQWLSRGGEIEGFRLSAHCSCDSRDNRPFLLLMATPL ERAQHLQSS D:  LDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHA NFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQ ALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS E:  LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP PGPLPEAVLALYNSTRDRVAGEPEPEADYYAKEVTRVLMV ETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAE LRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPE WLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQV DINGFMNRPFLLLMATPLERAQ F:  ALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYH ANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVP QALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS G:  TCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPG PLPEAVLALYNSTRDRVAGEPEADYYAKEVTRVLMVETHN EIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL RLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSF DVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDING FNRPFLLLMATPLERAQH H:  TNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANF CLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQAL EPLPIVYYVGRKPKVEQLSNMIVRSCKCS I:  HQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGN QLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHL EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSG LLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQ LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP DLAALPRLIYLNLSNNLIRLPIHAPSEGWSARPLSQLLNL DLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRD LPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFS GITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLN LAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLE TSLRRLYLQGNPLSCCGNGWLAAQLHQGRVD J:  HQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGN QLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHL EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSG LLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQ LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP DLAALPRLIYLNLSNNLIRLPIHAPSEGWSALQLLNLDLS YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP CLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPP YTFANLASLQRLNLQGNRVSPCCVAFSGITSLRSLSLVDN EIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASL EVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWT QAVSLEVLDLRNN K:  DIQVTQSSSYLSVSLGDRVTITCKASDHIKNWLAWYQQKP GIAPRLLVSGATSLEAGVPSRFSGSGSGKNFTLSITSLQT EDVATYYCQQYWSTPWTFGGGTTLEIRRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRN L:  QVQLKESGPGLVAPSQSLSITCTVSGFSLTGYGINWVRQP PGKGLEWLGMIWSDGSTDYNSVLTSRLRISKDNSNSQVFL KMNSLQVDDTARYYCARDRNYYDYDGAMDYWGQGTSVTVS SAKTTPPSVYPLAPSMVTLGCLVKGYFPEPVTVTWNSGSL SSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSQTVTCNVAH PASSTKVDKKIVPR M:  DIQVTQSSSYLSVSLGDRVTITCKASDHIKNWLAWYQQKP GIAPRLLVSGATSLEAGVPSRFSGSGSGKNFTLSITSLQT EDVATYYCQQYWSTPWTFGGGTTL N:  QVQLKESGPGLVAPSQSLSITCTVSGFSLTGYGINWVRQP PGKGLEWLGMIWSDGSTDYNSVLTSRLRISKDNSNSQVFL KMNSLQVDDTARYYCARDRNYYDYDGAMDYWGQGTSVT Description (1)  Transforming growth factor beta-1, Leucine-rich repeat-containing protein 32, MHG-8 Fab light chain, MHG-8 Fab heavy chain Functional site 1) chain B residue 311-326 type prosite sequence IHEPKGYHANFCLGPC description TGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC source prosite : PS00250 2) chain K residue 212-218 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290 3) chain I residue 203 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 4) chain I residue 271 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 5) chain I residue 345 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 6) chain I residue 545 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 7) chain J residue 203 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 8) chain J residue 271 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 9) chain J residue 345 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 10) chain J residue 545 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 11) chain C residue 136 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 12) chain C residue 176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 13) chain E residue 136 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 14) chain E residue 176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 15) chain G residue 136 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 16) chain G residue 176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3

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