Title
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Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab |
Classification
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IMMUNE SYSTEM |
Compound
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Transforming growth factor beta-1 |
Source
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ORGANISM_COMMON: Mouse; ORGANISM_SCIENTIFIC: Mus musculus; |
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Sequence
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A: |
LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP
PGPLPEAVLALYNSTRDRVEPEADYYAKEVTRVLIYMFFN
TSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQLSNR
LLAPSDSPEWLSFDVTGVVRQWLSEGFRLSAHCSCNRPFL
LLMATPLE
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B: |
ALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYH
ANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVP
QALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
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C: |
TCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPG
PLPEAVLALYNSTRDRVPEADYYAKEVTRVLMVETHNEIY
DKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLK
LKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVT
GVVRQWLSRGGEIEGFRLSAHCSCDSRDNRPFLLLMATPL
ERAQHLQSS
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D: |
LDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHA
NFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQ
ALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
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E: |
LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP
PGPLPEAVLALYNSTRDRVAGEPEPEADYYAKEVTRVLMV
ETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAE
LRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPE
WLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQV
DINGFMNRPFLLLMATPLERAQ
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F: |
ALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYH
ANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVP
QALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
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G: |
TCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPG
PLPEAVLALYNSTRDRVAGEPEADYYAKEVTRVLMVETHN
EIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL
RLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSF
DVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDING
FNRPFLLLMATPLERAQH
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H: |
TNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANF
CLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQAL
EPLPIVYYVGRKPKVEQLSNMIVRSCKCS
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I: |
HQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGN
QLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHL
EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSG
LLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD
LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQ
LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP
DLAALPRLIYLNLSNNLIRLPIHAPSEGWSARPLSQLLNL
DLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG
SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRD
LPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFS
GITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE
VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLN
LAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLE
TSLRRLYLQGNPLSCCGNGWLAAQLHQGRVD
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J: |
HQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGN
QLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHL
EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSG
LLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD
LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQ
LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP
DLAALPRLIYLNLSNNLIRLPIHAPSEGWSALQLLNLDLS
YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP
CLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPP
YTFANLASLQRLNLQGNRVSPCCVAFSGITSLRSLSLVDN
EIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASL
EVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWT
QAVSLEVLDLRNN
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K: |
DIQVTQSSSYLSVSLGDRVTITCKASDHIKNWLAWYQQKP
GIAPRLLVSGATSLEAGVPSRFSGSGSGKNFTLSITSLQT
EDVATYYCQQYWSTPWTFGGGTTLEIRRADAAPTVSIFPP
SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL
NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT
STSPIVKSFNRN
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L: |
QVQLKESGPGLVAPSQSLSITCTVSGFSLTGYGINWVRQP
PGKGLEWLGMIWSDGSTDYNSVLTSRLRISKDNSNSQVFL
KMNSLQVDDTARYYCARDRNYYDYDGAMDYWGQGTSVTVS
SAKTTPPSVYPLAPSMVTLGCLVKGYFPEPVTVTWNSGSL
SSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSQTVTCNVAH
PASSTKVDKKIVPR
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M: |
DIQVTQSSSYLSVSLGDRVTITCKASDHIKNWLAWYQQKP
GIAPRLLVSGATSLEAGVPSRFSGSGSGKNFTLSITSLQT
EDVATYYCQQYWSTPWTFGGGTTL
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N: |
QVQLKESGPGLVAPSQSLSITCTVSGFSLTGYGINWVRQP
PGKGLEWLGMIWSDGSTDYNSVLTSRLRISKDNSNSQVFL
KMNSLQVDDTARYYCARDRNYYDYDGAMDYWGQGTSVT
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Description
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(1) |
Transforming growth factor beta-1, Leucine-rich repeat-containing protein 32, MHG-8 Fab light chain, MHG-8 Fab heavy chain
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