eF-site ID 6gam-LMST PDB Code 6gam Chain L, M, S, T click to enlarge Title Structure of E14Q variant of E. coli hydrogenase-2 (as-isolated enzyme) Classification OXIDOREDUCTASE Compound Hydrogenase-2 small chain Source (MBHM_ECOLI) Sequence L:  SQRITIDPVTRIQGHLRIDCEIENGVVSKAWASGTMWRGM EEIVKNRDPRDAWMIVQRICGVCTTTHALSSVRAAESALN IDVPVNAQYIRNIILAAHTTHDHIVHFYQLSALDWVDITS ALQADPTKASEMLKGVSTWHLNSPEEFTKVQNKIKDLVAS GQLGIFANGYWGHPAMKLPPEVNLIAVAHYLQALECQRDA NRVVALLGGKTPHIQNLAVGGVANPINLDGLGVLNLERLM YIKSFIDKLSDFVEQVYKVDTAVIAAFYPEWLTRGKGAVN YLSVPEFPTDSKNGSFLFPGGYIENADLSSYRPITSHSDE YLIKGIQESAKHSWYKDEAPQAPWEGTTIPAYDGWSDDGK YSWVKSPTFYGKTVEVGPLANMLVKLAAGRESTQNKLNEI VAIYQKLTGNTLEVAQLHSTLGRIIGRTVHCCELQDILQN QYSALITNIGKGDHTTFVKPNIPATGEFKGVGFLEAPRGM LSHWMVIKDGIISNYQAVVPSTWNSGPRNFNDDVGPYEQS LVGTPVADPNKPLEVVRTIHSFDPCMACAVH M:  SQRITIDPVTRIQGHLRIDCEIENGVVSKAWASGTMWRGM EEIVKNRDPRDAWMIVQRICGVCTTTHALSSVRAAESALN IDVPVNAQYIRNIILAAHTTHDHIVHFYQLSALDWVDITS ALQADPTKASEMLKGVSTWHLNSPEEFTKVQNKIKDLVAS GQLGIFANGYWGHPAMKLPPEVNLIAVAHYLQALECQRDA NRVVALLGGKTPHIQNLAVGGVANPINLDGLGVLNLERLM YIKSFIDKLSDFVEQVYKVDTAVIAAFYPEWLTRGKGAVN YLSVPEFPTDSKNGSFLFPGGYIENADLSSYRPITSHSDE YLIKGIQESAKHSWYKDEAPQAPWEGTTIPAYDGWSDDGK YSWVKSPTFYGKTVEVGPLANMLVKLAAGRESTQNKLNEI VAIYQKLTGNTLEVAQLHSTLGRIIGRTVHCCELQDILQN QYSALITNIGKGDHTTFVKPNIPATGEFKGVGFLEAPRGM LSHWMVIKDGIISNYQAVVPSTWNSGPRNFNDDVGPYEQS LVGTPVADPNKPLEVVRTIHSFDPCMACAVH S:  QRPPVIWIGAQECTGCTESLLRATHPTVENLVLETISLEY HEVLSAAFGHQVEENKHNALEKYKGQYVLVVDGSIPLKDN GIYCMVAGEPIVDHIRKAAEGAAAIIAIGSCSAWGGVAAA GVNPTGAVSLQEVLPGKTVINIPGCPPNPHNFLATVAHII TYGKPPKLDDKNRPTFAYGRLIHEHCERRPHFDAGRFAKE FGDEGHREGWCLYHLGCKGPETYGNCSTLQFCDVGGVWPV AIGHPCYGCNEEGIGFHKGIHQLANVE T:  PQRPPVIWIGAQECTGCTESLLRATHPTVENLVLETISLE YHEVLSAAFGHQVEENKHNALEKYKGQYVLVVDGSIPLKD NGIYCMVAGEPIVDHIRKAAEGAAAIIAIGSCSAWGGVAA AGVNPTGAVSLQEVLPGKTVINIPGCPPNPHNFLATVAHI ITYGKPPKLDDKNRPTFAYGRLIHEHCERRPHFDAGRFAK EFGDEGHREGWCLYHLGCKGPETYGNCSTLQFCDVGGVWP VAIGHPCYGCNEEGIGFHKGIHQLANVE Description Functional site 1) chain S residue 192 type sequence H description binding site for residue SF4 S 401 source : AC1 2) chain S residue 195 type sequence C description binding site for residue SF4 S 401 source : AC1 3) chain S residue 197 type sequence R description binding site for residue SF4 S 401 source : AC1 4) chain S residue 198 type sequence R description binding site for residue SF4 S 401 source : AC1 5) chain S residue 220 type sequence C description binding site for residue SF4 S 401 source : AC1 6) chain S residue 221 type sequence L description binding site for residue SF4 S 401 source : AC1 7) chain S residue 222 type sequence Y description binding site for residue SF4 S 401 source : AC1 8) chain S residue 226 type sequence C description binding site for residue SF4 S 401 source : AC1 9) chain S residue 228 type sequence G description binding site for residue SF4 S 401 source : AC1 10) chain L residue 211 type sequence K description binding site for residue F3S S 402 source : AC2 11) chain L residue 216 type sequence Q description binding site for residue F3S S 402 source : AC2 12) chain S residue 235 type sequence C description binding site for residue F3S S 402 source : AC2 13) chain S residue 240 type sequence F description binding site for residue F3S S 402 source : AC2 14) chain S residue 255 type sequence C description binding site for residue F3S S 402 source : AC2 15) chain S residue 256 type sequence Y description binding site for residue F3S S 402 source : AC2 16) chain S residue 257 type sequence G description binding site for residue F3S S 402 source : AC2 17) chain S residue 258 type sequence C description binding site for residue F3S S 402 source : AC2 18) chain S residue 259 type sequence N description binding site for residue F3S S 402 source : AC2 19) chain L residue 59 type sequence R description binding site for residue SF4 S 403 source : AC3 20) chain S residue 22 type sequence C description binding site for residue SF4 S 403 source : AC3 21) chain S residue 25 type sequence C description binding site for residue SF4 S 403 source : AC3 22) chain S residue 118 type sequence G description binding site for residue SF4 S 403 source : AC3 23) chain S residue 119 type sequence S description binding site for residue SF4 S 403 source : AC3 24) chain S residue 120 type sequence C description binding site for residue SF4 S 403 source : AC3 25) chain S residue 153 type sequence G description binding site for residue SF4 S 403 source : AC3 26) chain S residue 154 type sequence C description binding site for residue SF4 S 403 source : AC3 27) chain S residue 155 type sequence P description binding site for residue SF4 S 403 source : AC3 28) chain L residue 64 type sequence C description binding site for residue FCO L 601 source : AC4 29) chain L residue 67 type sequence T description binding site for residue FCO L 601 source : AC4 30) chain L residue 68 type sequence H description binding site for residue FCO L 601 source : AC4 31) chain L residue 477 type sequence A description binding site for residue FCO L 601 source : AC4 32) chain L residue 478 type sequence P description binding site for residue FCO L 601 source : AC4 33) chain L residue 479 type sequence R description binding site for residue FCO L 601 source : AC4 34) chain L residue 482 type sequence L description binding site for residue FCO L 601 source : AC4 35) chain L residue 500 type sequence V description binding site for residue FCO L 601 source : AC4 36) chain L residue 501 type sequence P description binding site for residue FCO L 601 source : AC4 37) chain L residue 502 type sequence S description binding site for residue FCO L 601 source : AC4 38) chain L residue 549 type sequence C description binding site for residue FCO L 601 source : AC4 39) chain L residue 61 type sequence C description binding site for residue NI L 602 source : AC5 40) chain L residue 64 type sequence C description binding site for residue NI L 602 source : AC5 41) chain L residue 546 type sequence C description binding site for residue NI L 602 source : AC5 42) chain L residue 549 type sequence C description binding site for residue NI L 602 source : AC5 43) chain L residue 42 type sequence E description binding site for residue MG L 603 source : AC6 44) chain L residue 498 type sequence A description binding site for residue MG L 603 source : AC6 45) chain L residue 552 type sequence H description binding site for residue MG L 603 source : AC6 46) chain T residue 192 type sequence H description binding site for residue SF4 T 401 source : AC7 47) chain T residue 195 type sequence C description binding site for residue SF4 T 401 source : AC7 48) chain T residue 197 type sequence R description binding site for residue SF4 T 401 source : AC7 49) chain T residue 198 type sequence R description binding site for residue SF4 T 401 source : AC7 50) chain T residue 220 type sequence C description binding site for residue SF4 T 401 source : AC7 51) chain T residue 221 type sequence L description binding site for residue SF4 T 401 source : AC7 52) chain T residue 222 type sequence Y description binding site for residue SF4 T 401 source : AC7 53) chain T residue 226 type sequence C description binding site for residue SF4 T 401 source : AC7 54) chain M residue 211 type sequence K description binding site for residue F3S T 402 source : AC8 55) chain M residue 216 type sequence Q description binding site for residue F3S T 402 source : AC8 56) chain T residue 235 type sequence C description binding site for residue F3S T 402 source : AC8 57) chain T residue 240 type sequence F description binding site for residue F3S T 402 source : AC8 58) chain T residue 255 type sequence C description binding site for residue F3S T 402 source : AC8 59) chain T residue 256 type sequence Y description binding site for residue F3S T 402 source : AC8 60) chain T residue 257 type sequence G description binding site for residue F3S T 402 source : AC8 61) chain T residue 258 type sequence C description binding site for residue F3S T 402 source : AC8 62) chain T residue 259 type sequence N description binding site for residue F3S T 402 source : AC8 63) chain M residue 59 type sequence R description binding site for residue SF4 T 403 source : AC9 64) chain T residue 22 type sequence C description binding site for residue SF4 T 403 source : AC9 65) chain T residue 25 type sequence C description binding site for residue SF4 T 403 source : AC9 66) chain T residue 118 type sequence G description binding site for residue SF4 T 403 source : AC9 67) chain T residue 119 type sequence S description binding site for residue SF4 T 403 source : AC9 68) chain T residue 120 type sequence C description binding site for residue SF4 T 403 source : AC9 69) chain T residue 153 type sequence G description binding site for residue SF4 T 403 source : AC9 70) chain T residue 154 type sequence C description binding site for residue SF4 T 403 source : AC9 71) chain M residue 64 type sequence C description binding site for residue FCO M 601 source : AD1 72) chain M residue 67 type sequence T description binding site for residue FCO M 601 source : AD1 73) chain M residue 68 type sequence H description binding site for residue FCO M 601 source : AD1 74) chain M residue 477 type sequence A description binding site for residue FCO M 601 source : AD1 75) chain M residue 478 type sequence P description binding site for residue FCO M 601 source : AD1 76) chain M residue 479 type sequence R description binding site for residue FCO M 601 source : AD1 77) chain M residue 482 type sequence L description binding site for residue FCO M 601 source : AD1 78) chain M residue 500 type sequence V description binding site for residue FCO M 601 source : AD1 79) chain M residue 501 type sequence P description binding site for residue FCO M 601 source : AD1 80) chain M residue 502 type sequence S description binding site for residue FCO M 601 source : AD1 81) chain M residue 549 type sequence C description binding site for residue FCO M 601 source : AD1 82) chain M residue 61 type sequence C description binding site for residue NI M 602 source : AD2 83) chain M residue 64 type sequence C description binding site for residue NI M 602 source : AD2 84) chain M residue 546 type sequence C description binding site for residue NI M 602 source : AD2 85) chain M residue 549 type sequence C description binding site for residue NI M 602 source : AD2 86) chain M residue 42 type sequence E description binding site for residue MG M 603 source : AD3 87) chain M residue 498 type sequence A description binding site for residue MG M 603 source : AD3 88) chain M residue 552 type sequence H description binding site for residue MG M 603 source : AD3 89) chain L residue 39-64 type prosite sequence RGMEEIVKNRDPRDAWMIVQRICGVC description NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGMEeivknrdprdawmivQRiCGVC source prosite : PS00507 90) chain L residue 543-552 type prosite sequence FDPCMACAVH description NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. FDPCMACav.H source prosite : PS00508 91) chain L residue 552 type SITE sequence H description Cleavage; by HybD source Swiss-Prot : SWS_FT_FI2 92) chain M residue 552 type SITE sequence H description Cleavage; by HybD source Swiss-Prot : SWS_FT_FI2 93) chain S residue 255 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 94) chain S residue 258 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 95) chain T residue 22 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 96) chain T residue 25 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 97) chain T residue 120 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 98) chain T residue 154 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 99) chain T residue 192 type BINDING sequence H description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 100) chain T residue 195 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 101) chain T residue 220 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 102) chain T residue 226 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 103) chain T residue 235 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 104) chain T residue 255 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 105) chain T residue 258 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 106) chain S residue 235 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 107) chain L residue 61 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 108) chain L residue 64 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 109) chain L residue 546 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 110) chain L residue 549 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 111) chain M residue 61 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 112) chain M residue 64 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 113) chain M residue 546 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 114) chain M residue 549 type BINDING sequence C description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1

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