eF-site ID 6g9s-A PDB Code 6g9s Chain A click to enlarge Title Structural basis for the inhibition of E. coli PBP2 Classification HYDROLASE/ANTIBIOTIC Compound Peptidoglycan D,D-transpeptidase MrdA Source (MRDA_ECOLI) Sequence A:  NRIKLVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVD NVQQTLDALRSVVDLTDDDIAAFRKERARSHRFTSIPVKT NLTEVQVARFAVNQYRFPGVEVKGYKRRYYPYGSALTHVI GYVSKINDKDVERLNNDGKLANYAATHDIGKLGIERYYED VLHGQTGYEEVEVNNRGRVIRQLKEVPPQAGHDIYLTLDL KLQQYIETLLAGSRAAVVVTDPRTGGVLALVSTPSYDPNL FVDGISSKDYSALLNDPNTPLVNRATQGVYPPASTVKPYV AVSALSAGVITRNTTLFDPGWWQLPGSEKRYRDWKKWGHG RLNVTRSLEESADTFFYQVAYDMGIDRLSEWMGKFGYGHY TGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQG YWTATPIQMSKALMILINDGIVKVPHLLMSTAEDGKQVPW VQPHEPPVGDIHSGYWELAKDGMYGVANRPNGTAHKYFAS APYKIAAKSGTAQRDHKLMTAFAPYNNPQVAVAMILENGG AGPAVGTLMRQILDHIML Description Functional site 1) chain A residue 329 type sequence A description binding site for residue ET5 A 701 source : AC1 2) chain A residue 330 type sequence S description binding site for residue ET5 A 701 source : AC1 3) chain A residue 333 type sequence K description binding site for residue ET5 A 701 source : AC1 4) chain A residue 370 type sequence W description binding site for residue ET5 A 701 source : AC1 5) chain A residue 387 type sequence S description binding site for residue ET5 A 701 source : AC1 6) chain A residue 389 type sequence D description binding site for residue ET5 A 701 source : AC1 7) chain A residue 453 type sequence I description binding site for residue ET5 A 701 source : AC1 8) chain A residue 545 type sequence S description binding site for residue ET5 A 701 source : AC1 9) chain A residue 546 type sequence G description binding site for residue ET5 A 701 source : AC1 10) chain A residue 547 type sequence T description binding site for residue ET5 A 701 source : AC1 11) chain A residue 330 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000255|HAMAP-Rule:MF_02081, ECO:0000269|PubMed:3148617 source Swiss-Prot : SWS_FT_FI1

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