eF-site ID 6g8b-A PDB Code 6g8b Chain A click to enlarge Title E. coli Aminopeptidase N solved by Native SAD from a dataset collected in 60 second with JUNGFRAU detector Classification HYDROLASE Compound Aminopeptidase N Source (AMPN_ECOLI) Sequence A:  QQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQA VRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALV ISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEA EGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRV AQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFT TRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFG LEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDT ATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGL TVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAH PIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQK GMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQ SGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLH IPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFD NVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDF SRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAV LLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVRE ALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRN ACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVA AQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVL ETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDG SGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQE KMRAALEQLKGLENLSGDLYEKITKALA Description (1)  Aminopeptidase N (E.C.3.4.11.2) Functional site 1) chain A residue 297 type sequence H description binding site for residue ZN A 1001 source : AC1 2) chain A residue 301 type sequence H description binding site for residue ZN A 1001 source : AC1 3) chain A residue 320 type sequence E description binding site for residue ZN A 1001 source : AC1 4) chain A residue 332 type sequence S description binding site for residue NA A 1002 source : AC2 5) chain A residue 333 type sequence D description binding site for residue NA A 1002 source : AC2 6) chain A residue 335 type sequence G description binding site for residue NA A 1002 source : AC2 7) chain A residue 393 type sequence T description binding site for residue DMS A 1003 source : AC3 8) chain A residue 394 type sequence L description binding site for residue DMS A 1003 source : AC3 9) chain A residue 507 type sequence N description binding site for residue DMS A 1003 source : AC3 10) chain A residue 535 type sequence E description binding site for residue DMS A 1004 source : AC4 11) chain A residue 121 type sequence E description binding site for residue 7MF A 1005 source : AC5 12) chain A residue 260 type sequence M description binding site for residue 7MF A 1005 source : AC5 13) chain A residue 262 type sequence A description binding site for residue 7MF A 1005 source : AC5 14) chain A residue 264 type sequence E description binding site for residue 7MF A 1005 source : AC5 15) chain A residue 293 type sequence R description binding site for residue 7MF A 1005 source : AC5 16) chain A residue 297 type sequence H description binding site for residue 7MF A 1005 source : AC5 17) chain A residue 298 type sequence E description binding site for residue 7MF A 1005 source : AC5 18) chain A residue 301 type sequence H description binding site for residue 7MF A 1005 source : AC5 19) chain A residue 319 type sequence K description binding site for residue 7MF A 1005 source : AC5 20) chain A residue 320 type sequence E description binding site for residue 7MF A 1005 source : AC5 21) chain A residue 376 type sequence Y description binding site for residue 7MF A 1005 source : AC5 22) chain A residue 381 type sequence Y description binding site for residue 7MF A 1005 source : AC5 23) chain A residue 121 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 24) chain A residue 261 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 25) chain A residue 297 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 26) chain A residue 301 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 27) chain A residue 320 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 28) chain A residue 381 type SITE sequence Y description Transition state stabilizer => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 298 type ACT_SITE sequence E description Proton acceptor => ECO:0000305|PubMed:16885166, ECO:0000305|PubMed:18416562, ECO:0000305|PubMed:19622865 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 294-303 type prosite sequence VIGHEYFHNW description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW source prosite : PS00142

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