eF-site ID 6g77-A PDB Code 6g77 Chain A click to enlarge Title RSK4 N-terminal Kinase Domain in complex with AMP-PNP Classification TRANSFERASE Compound Ribosomal protein S6 kinase alpha-6 Source (KS6A6_HUMAN) Sequence A:  VVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLV RKKTGPDAGQLYAMKVLKKASLKVRDDILVEVNHPFIVKL HYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFY LAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG LSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWS YGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSA EAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKL YKREVQPPFKP Description Functional site 1) chain A residue 113 type sequence K description binding site for residue ANP A 401 source : AC1 2) chain A residue 115 type sequence R description binding site for residue ANP A 401 source : AC1 3) chain A residue 193 type sequence G description binding site for residue ANP A 401 source : AC1 4) chain A residue 197 type sequence R description binding site for residue ANP A 401 source : AC1 5) chain A residue 234 type sequence C description binding site for residue ANP A 401 source : AC1 6) chain A residue 247 type sequence R description binding site for residue ANP A 401 source : AC1 7) chain A residue 250 type sequence H description binding site for residue ANP A 401 source : AC1 8) chain A residue 80 type sequence G description binding site for residue ANP A 402 source : AC2 9) chain A residue 82 type sequence G description binding site for residue ANP A 402 source : AC2 10) chain A residue 83 type sequence S description binding site for residue ANP A 402 source : AC2 11) chain A residue 84 type sequence F description binding site for residue ANP A 402 source : AC2 12) chain A residue 87 type sequence V description binding site for residue ANP A 402 source : AC2 13) chain A residue 103 type sequence A description binding site for residue ANP A 402 source : AC2 14) chain A residue 105 type sequence K description binding site for residue ANP A 402 source : AC2 15) chain A residue 153 type sequence D description binding site for residue ANP A 402 source : AC2 16) chain A residue 155 type sequence L description binding site for residue ANP A 402 source : AC2 17) chain A residue 200 type sequence K description binding site for residue ANP A 402 source : AC2 18) chain A residue 202 type sequence E description binding site for residue ANP A 402 source : AC2 19) chain A residue 203 type sequence N description binding site for residue ANP A 402 source : AC2 20) chain A residue 205 type sequence L description binding site for residue ANP A 402 source : AC2 21) chain A residue 215 type sequence T description binding site for residue ANP A 402 source : AC2 22) chain A residue 221 type sequence K description binding site for residue ANP A 402 source : AC2 23) chain A residue 234 type sequence C description binding site for residue ZN A 403 source : AC3 24) chain A residue 250 type sequence H description binding site for residue ZN A 403 source : AC3 25) chain A residue 79-105 type prosite sequence LGQGSFGKVFLVRKKTGPDAGQLYAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGKVFlVrkktgpdagql.......YAMK source prosite : PS00107 26) chain A residue 194-206 type prosite sequence IVYRDLKPENILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvYrDLKpeNILL source prosite : PS00108 27) chain A residue 128-138 type prosite sequence VEVNHPFIVKL description SERPIN Serpins signature. VEVNHPFIVkL source prosite : PS00284 28) chain A residue 198 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 79 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 232 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15632195 source Swiss-Prot : SWS_FT_FI3

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