eF-site ID 6g76-AB PDB Code 6g76 Chain A, B click to enlarge Title Phosphorylated RSK4 N-terminal Kinase Domain in complex with AMP-PNP Classification TRANSFERASE Compound Ribosomal protein S6 kinase alpha-6 Source (KS6A6_HUMAN) Sequence A:  VVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLV RKKTGPDAGQLYAMKVLKKASLKVRDDILVEVNHPFIVKL HYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFY LAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG LSKESVDQEKKAYXFCGTVEYMAPEVVNRRGHSQSADWWS YGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSA EAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKL YKREVQPPFKP B:  VVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLV RKKTGPDAGQLYAMKVLKKASLKVRDILVEVNHPFIVKLH YAFQTKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAE LALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK ESVDVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLP FQGKDRNETLGMPQFLSAEAQSLLRMLFKRNPANRLGSEG VEEIKRHLFFANIDWDKLYKREVQPPFKP Description Functional site 1) chain A residue 79 type sequence L description binding site for residue ANP A 401 source : AC1 2) chain A residue 80 type sequence G description binding site for residue ANP A 401 source : AC1 3) chain A residue 82 type sequence G description binding site for residue ANP A 401 source : AC1 4) chain A residue 83 type sequence S description binding site for residue ANP A 401 source : AC1 5) chain A residue 84 type sequence F description binding site for residue ANP A 401 source : AC1 6) chain A residue 87 type sequence V description binding site for residue ANP A 401 source : AC1 7) chain A residue 103 type sequence A description binding site for residue ANP A 401 source : AC1 8) chain A residue 105 type sequence K description binding site for residue ANP A 401 source : AC1 9) chain A residue 153 type sequence D description binding site for residue ANP A 401 source : AC1 10) chain A residue 154 type sequence F description binding site for residue ANP A 401 source : AC1 11) chain A residue 155 type sequence L description binding site for residue ANP A 401 source : AC1 12) chain A residue 200 type sequence K description binding site for residue ANP A 401 source : AC1 13) chain A residue 203 type sequence N description binding site for residue ANP A 401 source : AC1 14) chain A residue 205 type sequence L description binding site for residue ANP A 401 source : AC1 15) chain A residue 215 type sequence T description binding site for residue ANP A 401 source : AC1 16) chain A residue 221 type sequence K description binding site for residue ANP A 401 source : AC1 17) chain A residue 113 type sequence K description binding site for residue ANP A 402 source : AC2 18) chain A residue 115 type sequence R description binding site for residue ANP A 402 source : AC2 19) chain A residue 193 type sequence G description binding site for residue ANP A 402 source : AC2 20) chain A residue 197 type sequence R description binding site for residue ANP A 402 source : AC2 21) chain A residue 220 type sequence S description binding site for residue ANP A 402 source : AC2 22) chain A residue 234 type sequence C description binding site for residue ANP A 402 source : AC2 23) chain A residue 247 type sequence R description binding site for residue ANP A 402 source : AC2 24) chain A residue 250 type sequence H description binding site for residue ANP A 402 source : AC2 25) chain A residue 234 type sequence C description binding site for residue ZN A 403 source : AC3 26) chain A residue 250 type sequence H description binding site for residue ZN A 403 source : AC3 27) chain B residue 80 type sequence G description binding site for residue ANP B 401 source : AC4 28) chain B residue 81 type sequence Q description binding site for residue ANP B 401 source : AC4 29) chain B residue 82 type sequence G description binding site for residue ANP B 401 source : AC4 30) chain B residue 83 type sequence S description binding site for residue ANP B 401 source : AC4 31) chain B residue 84 type sequence F description binding site for residue ANP B 401 source : AC4 32) chain B residue 87 type sequence V description binding site for residue ANP B 401 source : AC4 33) chain B residue 105 type sequence K description binding site for residue ANP B 401 source : AC4 34) chain B residue 136 type sequence V description binding site for residue ANP B 401 source : AC4 35) chain B residue 153 type sequence D description binding site for residue ANP B 401 source : AC4 36) chain B residue 155 type sequence L description binding site for residue ANP B 401 source : AC4 37) chain B residue 200 type sequence K description binding site for residue ANP B 401 source : AC4 38) chain B residue 202 type sequence E description binding site for residue ANP B 401 source : AC4 39) chain B residue 215 type sequence T description binding site for residue ANP B 401 source : AC4 40) chain B residue 221 type sequence K description binding site for residue ANP B 401 source : AC4 41) chain A residue 79-105 type prosite sequence LGQGSFGKVFLVRKKTGPDAGQLYAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGKVFlVrkktgpdagql.......YAMK source prosite : PS00107 42) chain A residue 194-206 type prosite sequence IVYRDLKPENILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvYrDLKpeNILL source prosite : PS00108 43) chain A residue 128-138 type prosite sequence VEVNHPFIVKL description SERPIN Serpins signature. VEVNHPFIVkL source prosite : PS00284 44) chain A residue 198 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 198 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 79 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 79 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 232 type MOD_RES sequence X description Phosphoserine => ECO:0000269|PubMed:15632195 source Swiss-Prot : SWS_FT_FI3

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