eF-site ID 6g5f-B PDB Code 6g5f Chain B click to enlarge Title Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1 Classification TOXIN Compound Botulinum neurotoxin type B Source (SYT1_HUMAN) Sequence B:  APGICIDVDNEDLFFIADKNSFSDDLSKNERIEYNTQSNY IENDFPINELILDTDLISKIELPSENTESLTDFNVDVPVY EKQPAIKKIFTDENTIFQYLYSQTFPLDIRDISLTSSFDD ALLFSNKVYSFFSMDYIKTANKVVEAGLFAGWVKQIVNDF VIEANKSNTMDKIADISLIVPYIGLALNVGNETAKGNFEN AFEIAGASILLEFIPELLIPVVGAFLLESYIDNKNKIIKT IDNALTKRNEKWSDMYGLIVAQWLSTVNTQFYTIKEGMYK ALNYQAQALEEIIKYRYNIYSEKEKSNINIDFNDINSKLN EGINQAIDNINNFINGCSVSYLMKKMIPLAVEKLLDFDNT LKKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLS IYTNDTILIEMFNKYNSEILNNIILNLRYKDNNLIDLSGY GAKVEVYDGVELNDKNQFKLTSSANSKIRVTQNQNIINSV FLDFSVSFWIRIPKYKNDGIQNYIHNEYTIINCMKNNSGW KISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRW FFVTITNNLNNAKIYINGKLESNTDIKDIREVIANGEIIF KLDGDIDRTQFIWMKYFSIFNTELSQSNIEERYKIQSYSE YLKDFWGNPLMYNKEYYMFNAGNKNSYIKLKKDSPVGEIL TRSKYNQNSKYINYRDLYIGEKFIIRRKSNSQSINDDIVR KEDYIYLDFFNLNQEWRVYTYKYFKKEEMKLFLAPIYDSD EFYNTIQIKEYDEQPTYSCQLLFKKDEESTDEIGLIGIHR FYESGIYKDYFCISKWYLKEVKRKPYNLKLGCNWQFIPKD EGWTE Description Functional site 1) chain B residue 452 type sequence E description binding site for residue GOL A 1301 source : AC1 2) chain B residue 705 type sequence L description binding site for residue GOL A 1302 source : AC2 3) chain B residue 709 type sequence N description binding site for residue GOL A 1302 source : AC2 4) chain B residue 452 type sequence E description binding site for residue MLI B 1301 source : AC4 5) chain B residue 454 type sequence L description binding site for residue MLI B 1301 source : AC4 6) chain B residue 456 type sequence F description binding site for residue MLI B 1301 source : AC4 7) chain B residue 710 type sequence T description binding site for residue MLI B 1301 source : AC4 8) chain B residue 713 type sequence Y description binding site for residue MLI B 1301 source : AC4 9) chain B residue 714 type sequence T description binding site for residue MLI B 1301 source : AC4 10) chain B residue 1025 type BINDING sequence N description BINDING => ECO:0007744|PDB:4KBB source Swiss-Prot : SWS_FT_FI4 11) chain B residue 1189 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB source Swiss-Prot : SWS_FT_FI5 12) chain B residue 1240 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB source Swiss-Prot : SWS_FT_FI5

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