eF-site ID 6g2d-BCDF PDB Code 6g2d Chain B, C, D, F click to enlarge Title Citrate-induced acetyl-CoA carboxylase (ACC-Cit) filament at 5.4 A resolution Classification LIGASE Compound Acetyl-CoA carboxylase 1 Source (ACACA_HUMAN) Sequence B:  KLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMK TLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYAS NITSVLCQFPSQQIANILDSHAEVFFMNTQSIVQLVQRYR SGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREE NKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLT DELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELR HNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPN FFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTC VVEFQFMLPTSHCQRMGGMVSFRTFEDFVRIFDEVMGCFE PIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGI RRLTFLVAQFPKFFTFRARDKFEEDRIYRHLEPALAFQLE LNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFF VRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFN NTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSR LWKLRVLQAELKINIRAIPIRLFLTNESGYYLDISLYKEV TAQIMFQAKQGPLHGMLINTPYVTK C:  VASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWS YEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGG PNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPEL LLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWS GSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAA EEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEV PGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQ RRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAG TVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQ LQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCP RGHVIAARITGTVQELNFRSNKNVWGYFSVQFGHCFSWGE NREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQM NRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLR NSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKV TRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTT YMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQY IVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRP GAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALR GEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERL MKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQY ASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNT QSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGH YDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLI DQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVL IASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLIL SETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNS VQHRQLKDNTCVVEFQFMLPTSHCQRMGGMVSFRTFEDFV RIFDEVMGCFEPIHILNVAIKTDCDIEDDRLAAMFREFTQ QNKATLVDHGIRRLTFLVAQFPKFFTFRARDKFEEDRIYR HLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVE VGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLL EAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEES VRSMVMRYGSRLWKLRVLQAELKINIRAIPIRLFLTNESG YYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPY VTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMS TQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEI GMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDL LFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVA WVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGE SRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYNEIITI SLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKV LGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLH WLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWM LAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRAR LGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQV WFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMY DQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVID SSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTM RRVDPVYIHLAERLGTPELSTAERKELENKLKEREEFLIP IYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYW RLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEG TVKAYVWDNNKDLAEWLEKQLTEEDGVHSVIEENIKCISR DYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRI L D:  VASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWS YEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGG PNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPEL LLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWS GSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAA EEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEV PGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQ RRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAG TVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQ LQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCP RGHVIAARITGTVQELNFRSNKNVWGYFSVQFGHCFSWGE NREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQM NRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLR NSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKV TRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTT YMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQY IVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRP GAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALR GEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERL MKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQY ASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNT QSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGH YDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLI DQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVL IASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLIL SETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNS VQHRQLKDNTCVVEFQFMLPTSHCQRMGGMVSFRTFEDFV RIFDEVMGCFEPIHILNVAIKTDCDIEDDRLAAMFREFTQ QNKATLVDHGIRRLTFLVAQFPKFFTFRARDKFEEDRIYR HLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVE VGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLL EAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEES VRSMVMRYGSRLWKLRVLQAELKINIRAIPIRLFLTNESG YYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPY VTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMS TQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEI GMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDL LFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVA WVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGE SRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYNEIITI SLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKV LGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLH WLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWM LAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRAR LGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQV WFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMY DQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVID SSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTM RRVDPVYIHLAERLGTPELSTAERKELENKLKEREEFLIP IYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYW RLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEG TVKAYVWDNNKDLAEWLEKQLTEEDGVHSVIEENIKCISR DYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRI L F:  KLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMK TLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYAS NITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQS IVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYD KCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQ LCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIA SHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSE TSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQ HRQLKDNTCVVEFQFMLPTSHCQRMGGMVSFRTFEDFVRI FDEVMGCFEPIHILNVAIKTDCDIEDDRLAAMFREFTQQN KATLVDHGIRRLTFLVAQFPKFFTFRARDKFEEDRIYRHL EPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVG TEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEA MDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVR SMVMRYGSRLWKLRVLQAELKINIRAIPIRLFLTNESGYY LDISLYKEVTAQIMFQAKQGPLHGMLINTPYVTK Description Functional site 1) chain C residue 441 type ACT_SITE sequence R description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 2) chain D residue 441 type ACT_SITE sequence R description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 488 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18220336 source Swiss-Prot : SWS_FT_FI15 4) chain D residue 488 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18220336 source Swiss-Prot : SWS_FT_FI15 5) chain C residue 610 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI16 6) chain C residue 2153 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI16 7) chain D residue 610 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI16 8) chain D residue 2153 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI16 9) chain C residue 786 type MOD_RES sequence K description N6-biotinyllysine => ECO:0000250|UniProtKB:P11497, ECO:0000255|PROSITE-ProRule:PRU01066 source Swiss-Prot : SWS_FT_FI17 10) chain D residue 786 type MOD_RES sequence K description N6-biotinyllysine => ECO:0000250|UniProtKB:P11497, ECO:0000255|PROSITE-ProRule:PRU01066 source Swiss-Prot : SWS_FT_FI17 11) chain C residue 835 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI18 12) chain D residue 835 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI18 13) chain C residue 315 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409 source Swiss-Prot : SWS_FT_FI2 14) chain D residue 315 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409 source Swiss-Prot : SWS_FT_FI2 15) chain C residue 424 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409, ECO:0000255|PROSITE-ProRule:PRU00969 source Swiss-Prot : SWS_FT_FI3 16) chain C residue 437 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409, ECO:0000255|PROSITE-ProRule:PRU00969 source Swiss-Prot : SWS_FT_FI3 17) chain C residue 439 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409, ECO:0000255|PROSITE-ProRule:PRU00969 source Swiss-Prot : SWS_FT_FI3 18) chain D residue 424 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409, ECO:0000255|PROSITE-ProRule:PRU00969 source Swiss-Prot : SWS_FT_FI3 19) chain D residue 437 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409, ECO:0000255|PROSITE-ProRule:PRU00969 source Swiss-Prot : SWS_FT_FI3 20) chain D residue 439 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00409, ECO:0000255|PROSITE-ProRule:PRU00969 source Swiss-Prot : SWS_FT_FI3 21) chain C residue 1823 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 22) chain C residue 2127 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 23) chain C residue 2129 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 24) chain D residue 1823 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 25) chain D residue 2127 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 26) chain D residue 2129 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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