eF-site ID 6fw3-D PDB Code 6fw3 Chain D click to enlarge Title Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007 Classification HYDROLASE Compound cAMP-specific 3',5'-cyclic phosphodiesterase 4D Source (PDE4D_HUMAN) Sequence D:  QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQ ERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAAD VVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCD IFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEK SQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ STIP Description Functional site 1) chain D residue 391 type sequence D description binding site for residue EDO A 508 source : AC8 2) chain D residue 235 type sequence A description binding site for residue EDO B 508 source : AF6 3) chain D residue 330 type sequence R description binding site for residue EDO C 515 source : AI3 4) chain D residue 221 type sequence L description binding site for residue PG4 C 519 source : AI7 5) chain D residue 222 type sequence M description binding site for residue PG4 C 519 source : AI7 6) chain D residue 224 type sequence N description binding site for residue PG4 C 519 source : AI7 7) chain D residue 140 type sequence D description binding site for residue EDO D 501 source : AI8 8) chain D residue 144 type sequence T description binding site for residue EDO D 501 source : AI8 9) chain D residue 147 type sequence M description binding site for residue EDO D 501 source : AI8 10) chain D residue 294 type sequence S description binding site for residue EDO D 502 source : AI9 11) chain D residue 295 type sequence S description binding site for residue EDO D 502 source : AI9 12) chain D residue 164 type sequence H description binding site for residue ZN D 503 source : AJ1 13) chain D residue 200 type sequence H description binding site for residue ZN D 503 source : AJ1 14) chain D residue 201 type sequence D description binding site for residue ZN D 503 source : AJ1 15) chain D residue 318 type sequence D description binding site for residue ZN D 503 source : AJ1 16) chain D residue 201 type sequence D description binding site for residue MG D 504 source : AJ2 17) chain D residue 391 type sequence D description binding site for residue EDO D 505 source : AJ3 18) chain D residue 259 type sequence S description binding site for residue EDO D 506 source : AJ4 19) chain D residue 303 type sequence Y description binding site for residue EDO D 506 source : AJ4 20) chain D residue 208 type sequence S description binding site for residue EDO D 507 source : AJ5 21) chain D residue 356 type sequence P description binding site for residue EDO D 507 source : AJ5 22) chain D residue 238 type sequence F description binding site for residue EDO D 508 source : AJ6 23) chain D residue 249 type sequence F description binding site for residue EDO D 508 source : AJ6 24) chain D residue 257 type sequence R description binding site for residue EDO D 508 source : AJ6 25) chain D residue 261 type sequence R description binding site for residue EDO D 508 source : AJ6 26) chain D residue 116 type sequence R description binding site for residue PEG D 509 source : AJ7 27) chain D residue 150 type sequence E description binding site for residue PEG D 509 source : AJ7 28) chain D residue 151 type sequence D description binding site for residue PEG D 509 source : AJ7 29) chain D residue 153 type sequence Y description binding site for residue PEG D 509 source : AJ7 30) chain D residue 154 type sequence H description binding site for residue PEG D 509 source : AJ7 31) chain D residue 155 type sequence A description binding site for residue PEG D 509 source : AJ7 32) chain D residue 182 type sequence E description binding site for residue EDO D 510 source : AJ8 33) chain D residue 148 type sequence T description binding site for residue EDO D 511 source : AJ9 34) chain D residue 152 type sequence H description binding site for residue EDO D 511 source : AJ9 35) chain D residue 243 type sequence E description binding site for residue EDO D 511 source : AJ9 36) chain D residue 262 type sequence K description binding site for residue EDO D 512 source : AK1 37) chain D residue 265 type sequence I description binding site for residue EDO D 512 source : AK1 38) chain D residue 266 type sequence D description binding site for residue EDO D 512 source : AK1 39) chain D residue 174 type sequence V description binding site for residue EDO D 513 source : AK2 40) chain D residue 178 type sequence T description binding site for residue EDO D 513 source : AK2 41) chain D residue 384 type sequence W description binding site for residue EDO D 513 source : AK2 42) chain D residue 98 type sequence D description binding site for residue EDO D 514 source : AK3 43) chain D residue 101 type sequence K description binding site for residue EDO D 514 source : AK3 44) chain D residue 102 type sequence W description binding site for residue EDO D 514 source : AK3 45) chain D residue 103 type sequence G description binding site for residue EDO D 514 source : AK3 46) chain D residue 105 type sequence H description binding site for residue EDO D 514 source : AK3 47) chain D residue 115 type sequence N description binding site for residue EDO D 515 source : AK4 48) chain D residue 155 type sequence A description binding site for residue EDO D 515 source : AK4 49) chain D residue 162 type sequence N description binding site for residue EDO D 515 source : AK4 50) chain D residue 105 type sequence H description binding site for residue EPE D 516 source : AK5 51) chain D residue 106 type sequence V description binding site for residue EPE D 516 source : AK5 52) chain D residue 107 type sequence F description binding site for residue EPE D 516 source : AK5 53) chain D residue 108 type sequence R description binding site for residue EPE D 516 source : AK5 54) chain D residue 111 type sequence E description binding site for residue EPE D 516 source : AK5 55) chain D residue 327 type sequence Q description binding site for residue EPE D 516 source : AK5 56) chain D residue 328 type sequence L description binding site for residue EPE D 516 source : AK5 57) chain D residue 331 type sequence Q description binding site for residue EPE D 516 source : AK5 58) chain D residue 266 type sequence D description binding site for residue EDO D 517 source : AK6 59) chain D residue 269 type sequence L description binding site for residue EDO D 517 source : AK6 60) chain D residue 270 type sequence A description binding site for residue EDO D 517 source : AK6 61) chain D residue 311 type sequence Q description binding site for residue EDO D 517 source : AK6 62) chain D residue 273 type sequence M description binding site for residue E8H D 518 source : AK7 63) chain D residue 321 type sequence N description binding site for residue E8H D 518 source : AK7 64) chain D residue 336 type sequence I description binding site for residue E8H D 518 source : AK7 65) chain D residue 357 type sequence M description binding site for residue E8H D 518 source : AK7 66) chain D residue 368 type sequence S description binding site for residue E8H D 518 source : AK7 67) chain D residue 369 type sequence Q description binding site for residue E8H D 518 source : AK7 68) chain D residue 372 type sequence F description binding site for residue E8H D 518 source : AK7 69) chain D residue 160 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 70) chain D residue 160 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 71) chain D residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 72) chain D residue 369 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 73) chain D residue 164 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 74) chain D residue 200 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 75) chain D residue 318 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 76) chain D residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 77) chain D residue 372 type BINDING sequence F description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5

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