eF-site ID 6fw3-ABCD PDB Code 6fw3 Chain A, B, C, D click to enlarge Title Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007 Classification HYDROLASE Compound cAMP-specific 3',5'-cyclic phosphodiesterase 4D Source (PDE4D_HUMAN) Sequence A:  GVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIM HTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNN IHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDV DHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQ EENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLAD LKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNP TKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHN ASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN REWYQSTIP B:  EDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADV VQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVS NQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDI FQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVE TKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS QVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQS TIP C:  TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTI FQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHA ADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN CDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKT MVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKP LQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASV EKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREW YQSTIP D:  QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQ ERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAAD VVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCD IFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEK SQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ STIP Description Functional site 1) chain A residue 164 type sequence H description binding site for residue ZN A 501 source : AC1 2) chain A residue 200 type sequence H description binding site for residue ZN A 501 source : AC1 3) chain A residue 201 type sequence D description binding site for residue ZN A 501 source : AC1 4) chain A residue 318 type sequence D description binding site for residue ZN A 501 source : AC1 5) chain A residue 201 type sequence D description binding site for residue MG A 502 source : AC2 6) chain A residue 208 type sequence S description binding site for residue EDO A 503 source : AC3 7) chain A residue 356 type sequence P description binding site for residue EDO A 503 source : AC3 8) chain A residue 358 type sequence C description binding site for residue EDO A 503 source : AC3 9) chain A residue 148 type sequence T description binding site for residue EDO A 504 source : AC4 10) chain A residue 152 type sequence H description binding site for residue EDO A 504 source : AC4 11) chain A residue 243 type sequence E description binding site for residue EDO A 504 source : AC4 12) chain C residue 212 type sequence L description binding site for residue EDO A 504 source : AC4 13) chain C residue 215 type sequence T description binding site for residue EDO A 504 source : AC4 14) chain A residue 218 type sequence E description binding site for residue EDO A 505 source : AC5 15) chain C residue 235 type sequence A description binding site for residue EDO A 505 source : AC5 16) chain A residue 100 type sequence N description binding site for residue EDO A 506 source : AC6 17) chain A residue 101 type sequence K description binding site for residue EDO A 506 source : AC6 18) chain A residue 102 type sequence W description binding site for residue EDO A 506 source : AC6 19) chain A residue 243 type sequence E description binding site for residue EDO A 507 source : AC7 20) chain A residue 244 type sequence E description binding site for residue EDO A 507 source : AC7 21) chain A residue 245 type sequence N description binding site for residue EDO A 507 source : AC7 22) chain A residue 134 type sequence T description binding site for residue EDO A 508 source : AC8 23) chain A residue 136 type sequence K description binding site for residue EDO A 508 source : AC8 24) chain D residue 391 type sequence D description binding site for residue EDO A 508 source : AC8 25) chain A residue 259 type sequence S description binding site for residue EDO A 509 source : AC9 26) chain A residue 262 type sequence K description binding site for residue EDO A 509 source : AC9 27) chain A residue 303 type sequence Y description binding site for residue EDO A 509 source : AC9 28) chain A residue 286 type sequence M description binding site for residue EDO A 510 source : AD1 29) chain A residue 289 type sequence T description binding site for residue EDO A 510 source : AD1 30) chain A residue 291 type sequence K description binding site for residue EDO A 510 source : AD1 31) chain A residue 299 type sequence L description binding site for residue EDO A 510 source : AD1 32) chain A residue 154 type sequence H description binding site for residue PEG A 511 source : AD2 33) chain A residue 156 type sequence D description binding site for residue PEG A 511 source : AD2 34) chain A residue 157 type sequence V description binding site for residue PEG A 511 source : AD2 35) chain A residue 205 type sequence P description binding site for residue PEG A 511 source : AD2 36) chain C residue 151 type sequence D description binding site for residue PEG A 511 source : AD2 37) chain C residue 152 type sequence H description binding site for residue PEG A 511 source : AD2 38) chain A residue 178 type sequence T description binding site for residue EDO A 512 source : AD3 39) chain A residue 384 type sequence W description binding site for residue EDO A 512 source : AD3 40) chain A residue 388 type sequence V description binding site for residue EDO A 512 source : AD3 41) chain A residue 115 type sequence N description binding site for residue EDO A 513 source : AD4 42) chain A residue 155 type sequence A description binding site for residue EDO A 513 source : AD4 43) chain A residue 162 type sequence N description binding site for residue EDO A 513 source : AD4 44) chain A residue 163 type sequence I description binding site for residue EDO A 513 source : AD4 45) chain A residue 335 type sequence R description binding site for residue EDO A 513 source : AD4 46) chain A residue 136 type sequence K description binding site for residue EDO A 514 source : AD5 47) chain A residue 251 type sequence N description binding site for residue EDO A 514 source : AD5 48) chain A residue 238 type sequence F description binding site for residue EDO A 515 source : AD6 49) chain A residue 257 type sequence R description binding site for residue EDO A 515 source : AD6 50) chain A residue 261 type sequence R description binding site for residue EDO A 515 source : AD6 51) chain A residue 218 type sequence E description binding site for residue EDO A 516 source : AD7 52) chain C residue 152 type sequence H description binding site for residue EDO A 516 source : AD7 53) chain A residue 262 type sequence K description binding site for residue EDO A 517 source : AD8 54) chain A residue 266 type sequence D description binding site for residue EDO A 517 source : AD8 55) chain A residue 209 type sequence N description binding site for residue EDO A 518 source : AD9 56) chain A residue 226 type sequence S description binding site for residue EDO A 518 source : AD9 57) chain A residue 227 type sequence S description binding site for residue EDO A 518 source : AD9 58) chain A residue 272 type sequence D description binding site for residue EDO A 518 source : AD9 59) chain A residue 274 type sequence S description binding site for residue EDO A 518 source : AD9 60) chain A residue 266 type sequence D description binding site for residue EDO A 519 source : AE1 61) chain A residue 269 type sequence L description binding site for residue EDO A 519 source : AE1 62) chain A residue 270 type sequence A description binding site for residue EDO A 519 source : AE1 63) chain A residue 275 type sequence K description binding site for residue EDO A 519 source : AE1 64) chain A residue 311 type sequence Q description binding site for residue EDO A 519 source : AE1 65) chain A residue 115 type sequence N description binding site for residue EDO A 520 source : AE2 66) chain A residue 116 type sequence R description binding site for residue EDO A 520 source : AE2 67) chain A residue 150 type sequence E description binding site for residue EDO A 520 source : AE2 68) chain A residue 151 type sequence D description binding site for residue EDO A 520 source : AE2 69) chain A residue 153 type sequence Y description binding site for residue EDO A 520 source : AE2 70) chain A residue 162 type sequence N description binding site for residue EDO A 520 source : AE2 71) chain A residue 105 type sequence H description binding site for residue EPE A 521 source : AE3 72) chain A residue 106 type sequence V description binding site for residue EPE A 521 source : AE3 73) chain A residue 107 type sequence F description binding site for residue EPE A 521 source : AE3 74) chain A residue 108 type sequence R description binding site for residue EPE A 521 source : AE3 75) chain A residue 325 type sequence P description binding site for residue EPE A 521 source : AE3 76) chain A residue 326 type sequence L description binding site for residue EPE A 521 source : AE3 77) chain A residue 327 type sequence Q description binding site for residue EPE A 521 source : AE3 78) chain A residue 328 type sequence L description binding site for residue EPE A 521 source : AE3 79) chain A residue 331 type sequence Q description binding site for residue EPE A 521 source : AE3 80) chain B residue 408 type sequence S description binding site for residue EPE A 521 source : AE3 81) chain A residue 140 type sequence D description binding site for residue EDO A 522 source : AE4 82) chain A residue 141 type sequence T description binding site for residue EDO A 522 source : AE4 83) chain A residue 245 type sequence N description binding site for residue EDO A 522 source : AE4 84) chain A residue 273 type sequence M description binding site for residue E8H A 523 source : AE5 85) chain A residue 319 type sequence L description binding site for residue E8H A 523 source : AE5 86) chain A residue 321 type sequence N description binding site for residue E8H A 523 source : AE5 87) chain A residue 336 type sequence I description binding site for residue E8H A 523 source : AE5 88) chain A residue 357 type sequence M description binding site for residue E8H A 523 source : AE5 89) chain A residue 369 type sequence Q description binding site for residue E8H A 523 source : AE5 90) chain A residue 372 type sequence F description binding site for residue E8H A 523 source : AE5 91) chain A residue 151 type sequence D description binding site for residue EDO A 524 source : AE6 92) chain A residue 153 type sequence Y description binding site for residue EDO A 524 source : AE6 93) chain A residue 154 type sequence H description binding site for residue EDO A 524 source : AE6 94) chain A residue 155 type sequence A description binding site for residue EDO A 524 source : AE6 95) chain C residue 156 type sequence D description binding site for residue EDO A 524 source : AE6 96) chain A residue 152 type sequence H description binding site for residue EDO A 525 source : AE7 97) chain C residue 218 type sequence E description binding site for residue EDO A 525 source : AE7 98) chain B residue 164 type sequence H description binding site for residue ZN B 501 source : AE8 99) chain B residue 200 type sequence H description binding site for residue ZN B 501 source : AE8 100) chain B residue 201 type sequence D description binding site for residue ZN B 501 source : AE8 101) chain B residue 318 type sequence D description binding site for residue ZN B 501 source : AE8 102) chain B residue 201 type sequence D description binding site for residue MG B 502 source : AE9 103) chain B residue 208 type sequence S description binding site for residue EDO B 503 source : AF1 104) chain B residue 340 type sequence F description binding site for residue EDO B 503 source : AF1 105) chain B residue 356 type sequence P description binding site for residue EDO B 503 source : AF1 106) chain B residue 358 type sequence C description binding site for residue EDO B 503 source : AF1 107) chain B residue 331 type sequence Q description binding site for residue EDO B 504 source : AF2 108) chain B residue 334 type sequence D description binding site for residue EDO B 504 source : AF2 109) chain B residue 335 type sequence R description binding site for residue EDO B 504 source : AF2 110) chain B residue 366 type sequence E description binding site for residue EDO B 505 source : AF3 111) chain B residue 409 type sequence T description binding site for residue EDO B 505 source : AF3 112) chain A residue 225 type sequence D description binding site for residue EDO B 506 source : AF4 113) chain B residue 262 type sequence K description binding site for residue EDO B 506 source : AF4 114) chain B residue 266 type sequence D description binding site for residue EDO B 506 source : AF4 115) chain B residue 140 type sequence D description binding site for residue EPE B 507 source : AF5 116) chain B residue 141 type sequence T description binding site for residue EPE B 507 source : AF5 117) chain B residue 245 type sequence N description binding site for residue EPE B 507 source : AF5 118) chain B residue 290 type sequence K description binding site for residue EPE B 507 source : AF5 119) chain B residue 292 type sequence V description binding site for residue EPE B 507 source : AF5 120) chain C residue 253 type sequence T description binding site for residue EPE B 507 source : AF5 121) chain C residue 254 type sequence K description binding site for residue EPE B 507 source : AF5 122) chain B residue 218 type sequence E description binding site for residue EDO B 508 source : AF6 123) chain D residue 235 type sequence A description binding site for residue EDO B 508 source : AF6 124) chain B residue 175 type sequence L description binding site for residue EDO B 509 source : AF7 125) chain B residue 178 type sequence T description binding site for residue EDO B 509 source : AF7 126) chain B residue 384 type sequence W description binding site for residue EDO B 509 source : AF7 127) chain B residue 391 type sequence D description binding site for residue EDO B 509 source : AF7 128) chain B residue 348 type sequence R description binding site for residue EDO B 510 source : AF8 129) chain B residue 360 type sequence K description binding site for residue EDO B 510 source : AF8 130) chain B residue 361 type sequence H description binding site for residue EDO B 510 source : AF8 131) chain B residue 115 type sequence N description binding site for residue EDO B 511 source : AF9 132) chain B residue 155 type sequence A description binding site for residue EDO B 511 source : AF9 133) chain B residue 161 type sequence N description binding site for residue EDO B 511 source : AF9 134) chain B residue 162 type sequence N description binding site for residue EDO B 511 source : AF9 135) chain B residue 335 type sequence R description binding site for residue EDO B 511 source : AF9 136) chain B residue 105 type sequence H description binding site for residue EPE B 512 source : AG1 137) chain B residue 106 type sequence V description binding site for residue EPE B 512 source : AG1 138) chain B residue 107 type sequence F description binding site for residue EPE B 512 source : AG1 139) chain B residue 108 type sequence R description binding site for residue EPE B 512 source : AG1 140) chain B residue 111 type sequence E description binding site for residue EPE B 512 source : AG1 141) chain B residue 327 type sequence Q description binding site for residue EPE B 512 source : AG1 142) chain B residue 328 type sequence L description binding site for residue EPE B 512 source : AG1 143) chain B residue 331 type sequence Q description binding site for residue EPE B 512 source : AG1 144) chain B residue 374 type sequence D description binding site for residue EDO B 513 source : AG2 145) chain B residue 378 type sequence H description binding site for residue EDO B 513 source : AG2 146) chain B residue 284 type sequence K description binding site for residue EDO B 514 source : AG3 147) chain B residue 287 type sequence V description binding site for residue EDO B 514 source : AG3 148) chain B residue 288 type sequence E description binding site for residue EDO B 514 source : AG3 149) chain B residue 383 type sequence T description binding site for residue EDO B 514 source : AG3 150) chain B residue 386 type sequence D description binding site for residue EDO B 514 source : AG3 151) chain B residue 389 type sequence H description binding site for residue EDO B 515 source : AG4 152) chain B residue 390 type sequence P description binding site for residue EDO B 515 source : AG4 153) chain C residue 134 type sequence T description binding site for residue EDO B 515 source : AG4 154) chain C residue 135 type sequence F description binding site for residue EDO B 515 source : AG4 155) chain C residue 136 type sequence K description binding site for residue EDO B 515 source : AG4 156) chain C residue 251 type sequence N description binding site for residue EDO B 515 source : AG4 157) chain C residue 256 type sequence Q description binding site for residue EDO B 515 source : AG4 158) chain B residue 210 type sequence Q description binding site for residue EDO B 516 source : AG5 159) chain B residue 273 type sequence M description binding site for residue E8H B 517 source : AG6 160) chain B residue 319 type sequence L description binding site for residue E8H B 517 source : AG6 161) chain B residue 321 type sequence N description binding site for residue E8H B 517 source : AG6 162) chain B residue 336 type sequence I description binding site for residue E8H B 517 source : AG6 163) chain B residue 357 type sequence M description binding site for residue E8H B 517 source : AG6 164) chain B residue 368 type sequence S description binding site for residue E8H B 517 source : AG6 165) chain B residue 369 type sequence Q description binding site for residue E8H B 517 source : AG6 166) chain B residue 372 type sequence F description binding site for residue E8H B 517 source : AG6 167) chain C residue 218 type sequence E description binding site for residue EDO C 501 source : AG7 168) chain B residue 179 type sequence P description binding site for residue EDO C 502 source : AG8 169) chain C residue 255 type sequence K description binding site for residue EDO C 502 source : AG8 170) chain C residue 259 type sequence S description binding site for residue EDO C 502 source : AG8 171) chain C residue 164 type sequence H description binding site for residue ZN C 503 source : AG9 172) chain C residue 200 type sequence H description binding site for residue ZN C 503 source : AG9 173) chain C residue 201 type sequence D description binding site for residue ZN C 503 source : AG9 174) chain C residue 318 type sequence D description binding site for residue ZN C 503 source : AG9 175) chain C residue 201 type sequence D description binding site for residue MG C 504 source : AH1 176) chain C residue 115 type sequence N description binding site for residue EDO C 505 source : AH2 177) chain C residue 116 type sequence R description binding site for residue EDO C 505 source : AH2 178) chain C residue 150 type sequence E description binding site for residue EDO C 505 source : AH2 179) chain C residue 153 type sequence Y description binding site for residue EDO C 505 source : AH2 180) chain C residue 162 type sequence N description binding site for residue EDO C 505 source : AH2 181) chain C residue 208 type sequence S description binding site for residue EDO C 506 source : AH3 182) chain C residue 356 type sequence P description binding site for residue EDO C 506 source : AH3 183) chain C residue 358 type sequence C description binding site for residue EDO C 506 source : AH3 184) chain C residue 238 type sequence F description binding site for residue EDO C 507 source : AH4 185) chain C residue 249 type sequence F description binding site for residue EDO C 507 source : AH4 186) chain C residue 257 type sequence R description binding site for residue EDO C 507 source : AH4 187) chain C residue 261 type sequence R description binding site for residue EDO C 507 source : AH4 188) chain C residue 140 type sequence D description binding site for residue EDO C 508 source : AH5 189) chain C residue 141 type sequence T description binding site for residue EDO C 508 source : AH5 190) chain C residue 245 type sequence N description binding site for residue EDO C 508 source : AH5 191) chain C residue 175 type sequence L description binding site for residue EDO C 509 source : AH6 192) chain C residue 178 type sequence T description binding site for residue EDO C 509 source : AH6 193) chain C residue 384 type sequence W description binding site for residue EDO C 509 source : AH6 194) chain C residue 388 type sequence V description binding site for residue EDO C 509 source : AH6 195) chain C residue 391 type sequence D description binding site for residue EDO C 509 source : AH6 196) chain C residue 395 type sequence I description binding site for residue EDO C 509 source : AH6 197) chain C residue 154 type sequence H description binding site for residue EDO C 510 source : AH7 198) chain C residue 203 type sequence D description binding site for residue EDO C 510 source : AH7 199) chain C residue 105 type sequence H description binding site for residue EPE C 511 source : AH8 200) chain C residue 107 type sequence F description binding site for residue EPE C 511 source : AH8 201) chain C residue 108 type sequence R description binding site for residue EPE C 511 source : AH8 202) chain C residue 111 type sequence E description binding site for residue EPE C 511 source : AH8 203) chain C residue 327 type sequence Q description binding site for residue EPE C 511 source : AH8 204) chain C residue 328 type sequence L description binding site for residue EPE C 511 source : AH8 205) chain C residue 331 type sequence Q description binding site for residue EPE C 511 source : AH8 206) chain C residue 115 type sequence N description binding site for residue EDO C 512 source : AH9 207) chain C residue 155 type sequence A description binding site for residue EDO C 512 source : AH9 208) chain C residue 162 type sequence N description binding site for residue EDO C 512 source : AH9 209) chain C residue 335 type sequence R description binding site for residue EDO C 512 source : AH9 210) chain C residue 277 type sequence M description binding site for residue EDO C 513 source : AI1 211) chain C residue 210 type sequence Q description binding site for residue EDO C 514 source : AI2 212) chain C residue 325 type sequence P description binding site for residue EDO C 515 source : AI3 213) chain C residue 326 type sequence L description binding site for residue EDO C 515 source : AI3 214) chain C residue 401 type sequence D description binding site for residue EDO C 515 source : AI3 215) chain C residue 402 type sequence N description binding site for residue EDO C 515 source : AI3 216) chain D residue 330 type sequence R description binding site for residue EDO C 515 source : AI3 217) chain A residue 211 type sequence F description binding site for residue EDO C 516 source : AI4 218) chain A residue 212 type sequence L description binding site for residue EDO C 516 source : AI4 219) chain A residue 217 type sequence S description binding site for residue EDO C 516 source : AI4 220) chain C residue 152 type sequence H description binding site for residue EDO C 516 source : AI4 221) chain C residue 243 type sequence E description binding site for residue EDO C 516 source : AI4 222) chain C residue 128 type sequence E description binding site for residue EDO C 517 source : AI5 223) chain C residue 173 type sequence H description binding site for residue EDO C 517 source : AI5 224) chain C residue 177 type sequence S description binding site for residue EDO C 517 source : AI5 225) chain C residue 273 type sequence M description binding site for residue E8H C 518 source : AI6 226) chain C residue 321 type sequence N description binding site for residue E8H C 518 source : AI6 227) chain C residue 336 type sequence I description binding site for residue E8H C 518 source : AI6 228) chain C residue 357 type sequence M description binding site for residue E8H C 518 source : AI6 229) chain C residue 369 type sequence Q description binding site for residue E8H C 518 source : AI6 230) chain C residue 371 type sequence G description binding site for residue E8H C 518 source : AI6 231) chain C residue 372 type sequence F description binding site for residue E8H C 518 source : AI6 232) chain C residue 376 type sequence I description binding site for residue E8H C 518 source : AI6 233) chain C residue 223 type sequence Y description binding site for residue PG4 C 519 source : AI7 234) chain C residue 231 type sequence N description binding site for residue PG4 C 519 source : AI7 235) chain C residue 234 type sequence L description binding site for residue PG4 C 519 source : AI7 236) chain C residue 235 type sequence A description binding site for residue PG4 C 519 source : AI7 237) chain C residue 238 type sequence F description binding site for residue PG4 C 519 source : AI7 238) chain C residue 261 type sequence R description binding site for residue PG4 C 519 source : AI7 239) chain D residue 221 type sequence L description binding site for residue PG4 C 519 source : AI7 240) chain D residue 222 type sequence M description binding site for residue PG4 C 519 source : AI7 241) chain D residue 224 type sequence N description binding site for residue PG4 C 519 source : AI7 242) chain B residue 349 type sequence E description binding site for residue EDO D 501 source : AI8 243) chain B residue 350 type sequence R description binding site for residue EDO D 501 source : AI8 244) chain D residue 140 type sequence D description binding site for residue EDO D 501 source : AI8 245) chain D residue 144 type sequence T description binding site for residue EDO D 501 source : AI8 246) chain D residue 147 type sequence M description binding site for residue EDO D 501 source : AI8 247) chain A residue 258 type sequence Q description binding site for residue EDO D 502 source : AI9 248) chain B residue 214 type sequence N description binding site for residue EDO D 502 source : AI9 249) chain D residue 294 type sequence S description binding site for residue EDO D 502 source : AI9 250) chain D residue 295 type sequence S description binding site for residue EDO D 502 source : AI9 251) chain D residue 164 type sequence H description binding site for residue ZN D 503 source : AJ1 252) chain D residue 200 type sequence H description binding site for residue ZN D 503 source : AJ1 253) chain D residue 201 type sequence D description binding site for residue ZN D 503 source : AJ1 254) chain D residue 318 type sequence D description binding site for residue ZN D 503 source : AJ1 255) chain D residue 201 type sequence D description binding site for residue MG D 504 source : AJ2 256) chain A residue 134 type sequence T description binding site for residue EDO D 505 source : AJ3 257) chain A residue 135 type sequence F description binding site for residue EDO D 505 source : AJ3 258) chain A residue 251 type sequence N description binding site for residue EDO D 505 source : AJ3 259) chain A residue 256 type sequence Q description binding site for residue EDO D 505 source : AJ3 260) chain D residue 391 type sequence D description binding site for residue EDO D 505 source : AJ3 261) chain D residue 259 type sequence S description binding site for residue EDO D 506 source : AJ4 262) chain D residue 303 type sequence Y description binding site for residue EDO D 506 source : AJ4 263) chain D residue 208 type sequence S description binding site for residue EDO D 507 source : AJ5 264) chain D residue 356 type sequence P description binding site for residue EDO D 507 source : AJ5 265) chain D residue 238 type sequence F description binding site for residue EDO D 508 source : AJ6 266) chain D residue 249 type sequence F description binding site for residue EDO D 508 source : AJ6 267) chain D residue 257 type sequence R description binding site for residue EDO D 508 source : AJ6 268) chain D residue 261 type sequence R description binding site for residue EDO D 508 source : AJ6 269) chain B residue 156 type sequence D description binding site for residue PEG D 509 source : AJ7 270) chain D residue 116 type sequence R description binding site for residue PEG D 509 source : AJ7 271) chain D residue 150 type sequence E description binding site for residue PEG D 509 source : AJ7 272) chain D residue 151 type sequence D description binding site for residue PEG D 509 source : AJ7 273) chain D residue 153 type sequence Y description binding site for residue PEG D 509 source : AJ7 274) chain D residue 154 type sequence H description binding site for residue PEG D 509 source : AJ7 275) chain D residue 155 type sequence A description binding site for residue PEG D 509 source : AJ7 276) chain A residue 256 type sequence Q description binding site for residue EDO D 510 source : AJ8 277) chain A residue 259 type sequence S description binding site for residue EDO D 510 source : AJ8 278) chain D residue 182 type sequence E description binding site for residue EDO D 510 source : AJ8 279) chain B residue 215 type sequence T description binding site for residue EDO D 511 source : AJ9 280) chain D residue 148 type sequence T description binding site for residue EDO D 511 source : AJ9 281) chain D residue 152 type sequence H description binding site for residue EDO D 511 source : AJ9 282) chain D residue 243 type sequence E description binding site for residue EDO D 511 source : AJ9 283) chain D residue 262 type sequence K description binding site for residue EDO D 512 source : AK1 284) chain D residue 265 type sequence I description binding site for residue EDO D 512 source : AK1 285) chain D residue 266 type sequence D description binding site for residue EDO D 512 source : AK1 286) chain D residue 174 type sequence V description binding site for residue EDO D 513 source : AK2 287) chain D residue 178 type sequence T description binding site for residue EDO D 513 source : AK2 288) chain D residue 384 type sequence W description binding site for residue EDO D 513 source : AK2 289) chain D residue 98 type sequence D description binding site for residue EDO D 514 source : AK3 290) chain D residue 101 type sequence K description binding site for residue EDO D 514 source : AK3 291) chain D residue 102 type sequence W description binding site for residue EDO D 514 source : AK3 292) chain D residue 103 type sequence G description binding site for residue EDO D 514 source : AK3 293) chain D residue 105 type sequence H description binding site for residue EDO D 514 source : AK3 294) chain D residue 115 type sequence N description binding site for residue EDO D 515 source : AK4 295) chain D residue 155 type sequence A description binding site for residue EDO D 515 source : AK4 296) chain D residue 162 type sequence N description binding site for residue EDO D 515 source : AK4 297) chain D residue 105 type sequence H description binding site for residue EPE D 516 source : AK5 298) chain D residue 106 type sequence V description binding site for residue EPE D 516 source : AK5 299) chain D residue 107 type sequence F description binding site for residue EPE D 516 source : AK5 300) chain D residue 108 type sequence R description binding site for residue EPE D 516 source : AK5 301) chain D residue 111 type sequence E description binding site for residue EPE D 516 source : AK5 302) chain D residue 327 type sequence Q description binding site for residue EPE D 516 source : AK5 303) chain D residue 328 type sequence L description binding site for residue EPE D 516 source : AK5 304) chain D residue 331 type sequence Q description binding site for residue EPE D 516 source : AK5 305) chain D residue 266 type sequence D description binding site for residue EDO D 517 source : AK6 306) chain D residue 269 type sequence L description binding site for residue EDO D 517 source : AK6 307) chain D residue 270 type sequence A description binding site for residue EDO D 517 source : AK6 308) chain D residue 311 type sequence Q description binding site for residue EDO D 517 source : AK6 309) chain D residue 273 type sequence M description binding site for residue E8H D 518 source : AK7 310) chain D residue 321 type sequence N description binding site for residue E8H D 518 source : AK7 311) chain D residue 336 type sequence I description binding site for residue E8H D 518 source : AK7 312) chain D residue 357 type sequence M description binding site for residue E8H D 518 source : AK7 313) chain D residue 368 type sequence S description binding site for residue E8H D 518 source : AK7 314) chain D residue 369 type sequence Q description binding site for residue E8H D 518 source : AK7 315) chain D residue 372 type sequence F description binding site for residue E8H D 518 source : AK7 316) chain A residue 200-211 type prosite sequence HDVDHPGVSNQF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF source prosite : PS00126 317) chain A residue 160 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 318) chain B residue 160 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 319) chain C residue 160 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 320) chain D residue 160 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 321) chain A residue 160 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 322) chain D residue 160 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 323) chain D residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 324) chain D residue 369 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 325) chain A residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 326) chain A residue 369 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 327) chain B residue 160 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 328) chain B residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 329) chain B residue 369 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 330) chain C residue 160 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 331) chain C residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 332) chain C residue 369 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 333) chain A residue 164 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 334) chain B residue 164 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 335) chain C residue 164 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 336) chain D residue 164 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 337) chain A residue 200 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 338) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 339) chain B residue 200 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 340) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 341) chain C residue 200 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 342) chain C residue 318 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 343) chain D residue 200 type BINDING sequence H description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 344) chain D residue 318 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 345) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 346) chain A residue 372 type BINDING sequence F description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 347) chain B residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 348) chain B residue 372 type BINDING sequence F description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 349) chain C residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 350) chain C residue 372 type BINDING sequence F description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 351) chain D residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 352) chain D residue 372 type BINDING sequence F description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 353) chain A residue 85 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) source Swiss-Prot : SWS_FT_FI6

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