eF-site ID 6fw3-ABCD
PDB Code 6fw3
Chain A, B, C, D

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Title Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007
Classification HYDROLASE
Compound cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Source (PDE4D_HUMAN)
Sequence A:  GVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIM
HTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNN
IHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDV
DHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQ
EENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLAD
LKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNP
TKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHN
ASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN
REWYQSTIP
B:  EDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADV
VQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVS
NQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDI
FQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVE
TKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS
QVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQS
TIP
C:  TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTI
FQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHA
ADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP
GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN
CDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKT
MVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKP
LQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASV
EKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREW
YQSTIP
D:  QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQ
ERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAAD
VVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV
SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCD
IFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV
ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ
LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEK
SQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ
STIP
Description


Functional site

1) chain A
residue 164
type
sequence H
description binding site for residue ZN A 501
source : AC1

2) chain A
residue 200
type
sequence H
description binding site for residue ZN A 501
source : AC1

3) chain A
residue 201
type
sequence D
description binding site for residue ZN A 501
source : AC1

4) chain A
residue 318
type
sequence D
description binding site for residue ZN A 501
source : AC1

5) chain A
residue 201
type
sequence D
description binding site for residue MG A 502
source : AC2

6) chain A
residue 208
type
sequence S
description binding site for residue EDO A 503
source : AC3

7) chain A
residue 356
type
sequence P
description binding site for residue EDO A 503
source : AC3

8) chain A
residue 358
type
sequence C
description binding site for residue EDO A 503
source : AC3

9) chain A
residue 148
type
sequence T
description binding site for residue EDO A 504
source : AC4

10) chain A
residue 152
type
sequence H
description binding site for residue EDO A 504
source : AC4

11) chain A
residue 243
type
sequence E
description binding site for residue EDO A 504
source : AC4

12) chain C
residue 212
type
sequence L
description binding site for residue EDO A 504
source : AC4

13) chain C
residue 215
type
sequence T
description binding site for residue EDO A 504
source : AC4

14) chain A
residue 218
type
sequence E
description binding site for residue EDO A 505
source : AC5

15) chain C
residue 235
type
sequence A
description binding site for residue EDO A 505
source : AC5

16) chain A
residue 100
type
sequence N
description binding site for residue EDO A 506
source : AC6

17) chain A
residue 101
type
sequence K
description binding site for residue EDO A 506
source : AC6

18) chain A
residue 102
type
sequence W
description binding site for residue EDO A 506
source : AC6

19) chain A
residue 243
type
sequence E
description binding site for residue EDO A 507
source : AC7

20) chain A
residue 244
type
sequence E
description binding site for residue EDO A 507
source : AC7

21) chain A
residue 245
type
sequence N
description binding site for residue EDO A 507
source : AC7

22) chain A
residue 134
type
sequence T
description binding site for residue EDO A 508
source : AC8

23) chain A
residue 136
type
sequence K
description binding site for residue EDO A 508
source : AC8

24) chain D
residue 391
type
sequence D
description binding site for residue EDO A 508
source : AC8

25) chain A
residue 259
type
sequence S
description binding site for residue EDO A 509
source : AC9

26) chain A
residue 262
type
sequence K
description binding site for residue EDO A 509
source : AC9

27) chain A
residue 303
type
sequence Y
description binding site for residue EDO A 509
source : AC9

28) chain A
residue 286
type
sequence M
description binding site for residue EDO A 510
source : AD1

29) chain A
residue 289
type
sequence T
description binding site for residue EDO A 510
source : AD1

30) chain A
residue 291
type
sequence K
description binding site for residue EDO A 510
source : AD1

31) chain A
residue 299
type
sequence L
description binding site for residue EDO A 510
source : AD1

32) chain A
residue 154
type
sequence H
description binding site for residue PEG A 511
source : AD2

33) chain A
residue 156
type
sequence D
description binding site for residue PEG A 511
source : AD2

34) chain A
residue 157
type
sequence V
description binding site for residue PEG A 511
source : AD2

35) chain A
residue 205
type
sequence P
description binding site for residue PEG A 511
source : AD2

36) chain C
residue 151
type
sequence D
description binding site for residue PEG A 511
source : AD2

37) chain C
residue 152
type
sequence H
description binding site for residue PEG A 511
source : AD2

38) chain A
residue 178
type
sequence T
description binding site for residue EDO A 512
source : AD3

39) chain A
residue 384
type
sequence W
description binding site for residue EDO A 512
source : AD3

40) chain A
residue 388
type
sequence V
description binding site for residue EDO A 512
source : AD3

41) chain A
residue 115
type
sequence N
description binding site for residue EDO A 513
source : AD4

42) chain A
residue 155
type
sequence A
description binding site for residue EDO A 513
source : AD4

43) chain A
residue 162
type
sequence N
description binding site for residue EDO A 513
source : AD4

44) chain A
residue 163
type
sequence I
description binding site for residue EDO A 513
source : AD4

45) chain A
residue 335
type
sequence R
description binding site for residue EDO A 513
source : AD4

46) chain A
residue 136
type
sequence K
description binding site for residue EDO A 514
source : AD5

47) chain A
residue 251
type
sequence N
description binding site for residue EDO A 514
source : AD5

48) chain A
residue 238
type
sequence F
description binding site for residue EDO A 515
source : AD6

49) chain A
residue 257
type
sequence R
description binding site for residue EDO A 515
source : AD6

50) chain A
residue 261
type
sequence R
description binding site for residue EDO A 515
source : AD6

51) chain A
residue 218
type
sequence E
description binding site for residue EDO A 516
source : AD7

52) chain C
residue 152
type
sequence H
description binding site for residue EDO A 516
source : AD7

53) chain A
residue 262
type
sequence K
description binding site for residue EDO A 517
source : AD8

54) chain A
residue 266
type
sequence D
description binding site for residue EDO A 517
source : AD8

55) chain A
residue 209
type
sequence N
description binding site for residue EDO A 518
source : AD9

56) chain A
residue 226
type
sequence S
description binding site for residue EDO A 518
source : AD9

57) chain A
residue 227
type
sequence S
description binding site for residue EDO A 518
source : AD9

58) chain A
residue 272
type
sequence D
description binding site for residue EDO A 518
source : AD9

59) chain A
residue 274
type
sequence S
description binding site for residue EDO A 518
source : AD9

60) chain A
residue 266
type
sequence D
description binding site for residue EDO A 519
source : AE1

61) chain A
residue 269
type
sequence L
description binding site for residue EDO A 519
source : AE1

62) chain A
residue 270
type
sequence A
description binding site for residue EDO A 519
source : AE1

63) chain A
residue 275
type
sequence K
description binding site for residue EDO A 519
source : AE1

64) chain A
residue 311
type
sequence Q
description binding site for residue EDO A 519
source : AE1

65) chain A
residue 115
type
sequence N
description binding site for residue EDO A 520
source : AE2

66) chain A
residue 116
type
sequence R
description binding site for residue EDO A 520
source : AE2

67) chain A
residue 150
type
sequence E
description binding site for residue EDO A 520
source : AE2

68) chain A
residue 151
type
sequence D
description binding site for residue EDO A 520
source : AE2

69) chain A
residue 153
type
sequence Y
description binding site for residue EDO A 520
source : AE2

70) chain A
residue 162
type
sequence N
description binding site for residue EDO A 520
source : AE2

71) chain A
residue 105
type
sequence H
description binding site for residue EPE A 521
source : AE3

72) chain A
residue 106
type
sequence V
description binding site for residue EPE A 521
source : AE3

73) chain A
residue 107
type
sequence F
description binding site for residue EPE A 521
source : AE3

74) chain A
residue 108
type
sequence R
description binding site for residue EPE A 521
source : AE3

75) chain A
residue 325
type
sequence P
description binding site for residue EPE A 521
source : AE3

76) chain A
residue 326
type
sequence L
description binding site for residue EPE A 521
source : AE3

77) chain A
residue 327
type
sequence Q
description binding site for residue EPE A 521
source : AE3

78) chain A
residue 328
type
sequence L
description binding site for residue EPE A 521
source : AE3

79) chain A
residue 331
type
sequence Q
description binding site for residue EPE A 521
source : AE3

80) chain B
residue 408
type
sequence S
description binding site for residue EPE A 521
source : AE3

81) chain A
residue 140
type
sequence D
description binding site for residue EDO A 522
source : AE4

82) chain A
residue 141
type
sequence T
description binding site for residue EDO A 522
source : AE4

83) chain A
residue 245
type
sequence N
description binding site for residue EDO A 522
source : AE4

84) chain A
residue 273
type
sequence M
description binding site for residue E8H A 523
source : AE5

85) chain A
residue 319
type
sequence L
description binding site for residue E8H A 523
source : AE5

86) chain A
residue 321
type
sequence N
description binding site for residue E8H A 523
source : AE5

87) chain A
residue 336
type
sequence I
description binding site for residue E8H A 523
source : AE5

88) chain A
residue 357
type
sequence M
description binding site for residue E8H A 523
source : AE5

89) chain A
residue 369
type
sequence Q
description binding site for residue E8H A 523
source : AE5

90) chain A
residue 372
type
sequence F
description binding site for residue E8H A 523
source : AE5

91) chain A
residue 151
type
sequence D
description binding site for residue EDO A 524
source : AE6

92) chain A
residue 153
type
sequence Y
description binding site for residue EDO A 524
source : AE6

93) chain A
residue 154
type
sequence H
description binding site for residue EDO A 524
source : AE6

94) chain A
residue 155
type
sequence A
description binding site for residue EDO A 524
source : AE6

95) chain C
residue 156
type
sequence D
description binding site for residue EDO A 524
source : AE6

96) chain A
residue 152
type
sequence H
description binding site for residue EDO A 525
source : AE7

97) chain C
residue 218
type
sequence E
description binding site for residue EDO A 525
source : AE7

98) chain B
residue 164
type
sequence H
description binding site for residue ZN B 501
source : AE8

99) chain B
residue 200
type
sequence H
description binding site for residue ZN B 501
source : AE8

100) chain B
residue 201
type
sequence D
description binding site for residue ZN B 501
source : AE8

101) chain B
residue 318
type
sequence D
description binding site for residue ZN B 501
source : AE8

102) chain B
residue 201
type
sequence D
description binding site for residue MG B 502
source : AE9

103) chain B
residue 208
type
sequence S
description binding site for residue EDO B 503
source : AF1

104) chain B
residue 340
type
sequence F
description binding site for residue EDO B 503
source : AF1

105) chain B
residue 356
type
sequence P
description binding site for residue EDO B 503
source : AF1

106) chain B
residue 358
type
sequence C
description binding site for residue EDO B 503
source : AF1

107) chain B
residue 331
type
sequence Q
description binding site for residue EDO B 504
source : AF2

108) chain B
residue 334
type
sequence D
description binding site for residue EDO B 504
source : AF2

109) chain B
residue 335
type
sequence R
description binding site for residue EDO B 504
source : AF2

110) chain B
residue 366
type
sequence E
description binding site for residue EDO B 505
source : AF3

111) chain B
residue 409
type
sequence T
description binding site for residue EDO B 505
source : AF3

112) chain A
residue 225
type
sequence D
description binding site for residue EDO B 506
source : AF4

113) chain B
residue 262
type
sequence K
description binding site for residue EDO B 506
source : AF4

114) chain B
residue 266
type
sequence D
description binding site for residue EDO B 506
source : AF4

115) chain B
residue 140
type
sequence D
description binding site for residue EPE B 507
source : AF5

116) chain B
residue 141
type
sequence T
description binding site for residue EPE B 507
source : AF5

117) chain B
residue 245
type
sequence N
description binding site for residue EPE B 507
source : AF5

118) chain B
residue 290
type
sequence K
description binding site for residue EPE B 507
source : AF5

119) chain B
residue 292
type
sequence V
description binding site for residue EPE B 507
source : AF5

120) chain C
residue 253
type
sequence T
description binding site for residue EPE B 507
source : AF5

121) chain C
residue 254
type
sequence K
description binding site for residue EPE B 507
source : AF5

122) chain B
residue 218
type
sequence E
description binding site for residue EDO B 508
source : AF6

123) chain D
residue 235
type
sequence A
description binding site for residue EDO B 508
source : AF6

124) chain B
residue 175
type
sequence L
description binding site for residue EDO B 509
source : AF7

125) chain B
residue 178
type
sequence T
description binding site for residue EDO B 509
source : AF7

126) chain B
residue 384
type
sequence W
description binding site for residue EDO B 509
source : AF7

127) chain B
residue 391
type
sequence D
description binding site for residue EDO B 509
source : AF7

128) chain B
residue 348
type
sequence R
description binding site for residue EDO B 510
source : AF8

129) chain B
residue 360
type
sequence K
description binding site for residue EDO B 510
source : AF8

130) chain B
residue 361
type
sequence H
description binding site for residue EDO B 510
source : AF8

131) chain B
residue 115
type
sequence N
description binding site for residue EDO B 511
source : AF9

132) chain B
residue 155
type
sequence A
description binding site for residue EDO B 511
source : AF9

133) chain B
residue 161
type
sequence N
description binding site for residue EDO B 511
source : AF9

134) chain B
residue 162
type
sequence N
description binding site for residue EDO B 511
source : AF9

135) chain B
residue 335
type
sequence R
description binding site for residue EDO B 511
source : AF9

136) chain B
residue 105
type
sequence H
description binding site for residue EPE B 512
source : AG1

137) chain B
residue 106
type
sequence V
description binding site for residue EPE B 512
source : AG1

138) chain B
residue 107
type
sequence F
description binding site for residue EPE B 512
source : AG1

139) chain B
residue 108
type
sequence R
description binding site for residue EPE B 512
source : AG1

140) chain B
residue 111
type
sequence E
description binding site for residue EPE B 512
source : AG1

141) chain B
residue 327
type
sequence Q
description binding site for residue EPE B 512
source : AG1

142) chain B
residue 328
type
sequence L
description binding site for residue EPE B 512
source : AG1

143) chain B
residue 331
type
sequence Q
description binding site for residue EPE B 512
source : AG1

144) chain B
residue 374
type
sequence D
description binding site for residue EDO B 513
source : AG2

145) chain B
residue 378
type
sequence H
description binding site for residue EDO B 513
source : AG2

146) chain B
residue 284
type
sequence K
description binding site for residue EDO B 514
source : AG3

147) chain B
residue 287
type
sequence V
description binding site for residue EDO B 514
source : AG3

148) chain B
residue 288
type
sequence E
description binding site for residue EDO B 514
source : AG3

149) chain B
residue 383
type
sequence T
description binding site for residue EDO B 514
source : AG3

150) chain B
residue 386
type
sequence D
description binding site for residue EDO B 514
source : AG3

151) chain B
residue 389
type
sequence H
description binding site for residue EDO B 515
source : AG4

152) chain B
residue 390
type
sequence P
description binding site for residue EDO B 515
source : AG4

153) chain C
residue 134
type
sequence T
description binding site for residue EDO B 515
source : AG4

154) chain C
residue 135
type
sequence F
description binding site for residue EDO B 515
source : AG4

155) chain C
residue 136
type
sequence K
description binding site for residue EDO B 515
source : AG4

156) chain C
residue 251
type
sequence N
description binding site for residue EDO B 515
source : AG4

157) chain C
residue 256
type
sequence Q
description binding site for residue EDO B 515
source : AG4

158) chain B
residue 210
type
sequence Q
description binding site for residue EDO B 516
source : AG5

159) chain B
residue 273
type
sequence M
description binding site for residue E8H B 517
source : AG6

160) chain B
residue 319
type
sequence L
description binding site for residue E8H B 517
source : AG6

161) chain B
residue 321
type
sequence N
description binding site for residue E8H B 517
source : AG6

162) chain B
residue 336
type
sequence I
description binding site for residue E8H B 517
source : AG6

163) chain B
residue 357
type
sequence M
description binding site for residue E8H B 517
source : AG6

164) chain B
residue 368
type
sequence S
description binding site for residue E8H B 517
source : AG6

165) chain B
residue 369
type
sequence Q
description binding site for residue E8H B 517
source : AG6

166) chain B
residue 372
type
sequence F
description binding site for residue E8H B 517
source : AG6

167) chain C
residue 218
type
sequence E
description binding site for residue EDO C 501
source : AG7

168) chain B
residue 179
type
sequence P
description binding site for residue EDO C 502
source : AG8

169) chain C
residue 255
type
sequence K
description binding site for residue EDO C 502
source : AG8

170) chain C
residue 259
type
sequence S
description binding site for residue EDO C 502
source : AG8

171) chain C
residue 164
type
sequence H
description binding site for residue ZN C 503
source : AG9

172) chain C
residue 200
type
sequence H
description binding site for residue ZN C 503
source : AG9

173) chain C
residue 201
type
sequence D
description binding site for residue ZN C 503
source : AG9

174) chain C
residue 318
type
sequence D
description binding site for residue ZN C 503
source : AG9

175) chain C
residue 201
type
sequence D
description binding site for residue MG C 504
source : AH1

176) chain C
residue 115
type
sequence N
description binding site for residue EDO C 505
source : AH2

177) chain C
residue 116
type
sequence R
description binding site for residue EDO C 505
source : AH2

178) chain C
residue 150
type
sequence E
description binding site for residue EDO C 505
source : AH2

179) chain C
residue 153
type
sequence Y
description binding site for residue EDO C 505
source : AH2

180) chain C
residue 162
type
sequence N
description binding site for residue EDO C 505
source : AH2

181) chain C
residue 208
type
sequence S
description binding site for residue EDO C 506
source : AH3

182) chain C
residue 356
type
sequence P
description binding site for residue EDO C 506
source : AH3

183) chain C
residue 358
type
sequence C
description binding site for residue EDO C 506
source : AH3

184) chain C
residue 238
type
sequence F
description binding site for residue EDO C 507
source : AH4

185) chain C
residue 249
type
sequence F
description binding site for residue EDO C 507
source : AH4

186) chain C
residue 257
type
sequence R
description binding site for residue EDO C 507
source : AH4

187) chain C
residue 261
type
sequence R
description binding site for residue EDO C 507
source : AH4

188) chain C
residue 140
type
sequence D
description binding site for residue EDO C 508
source : AH5

189) chain C
residue 141
type
sequence T
description binding site for residue EDO C 508
source : AH5

190) chain C
residue 245
type
sequence N
description binding site for residue EDO C 508
source : AH5

191) chain C
residue 175
type
sequence L
description binding site for residue EDO C 509
source : AH6

192) chain C
residue 178
type
sequence T
description binding site for residue EDO C 509
source : AH6

193) chain C
residue 384
type
sequence W
description binding site for residue EDO C 509
source : AH6

194) chain C
residue 388
type
sequence V
description binding site for residue EDO C 509
source : AH6

195) chain C
residue 391
type
sequence D
description binding site for residue EDO C 509
source : AH6

196) chain C
residue 395
type
sequence I
description binding site for residue EDO C 509
source : AH6

197) chain C
residue 154
type
sequence H
description binding site for residue EDO C 510
source : AH7

198) chain C
residue 203
type
sequence D
description binding site for residue EDO C 510
source : AH7

199) chain C
residue 105
type
sequence H
description binding site for residue EPE C 511
source : AH8

200) chain C
residue 107
type
sequence F
description binding site for residue EPE C 511
source : AH8

201) chain C
residue 108
type
sequence R
description binding site for residue EPE C 511
source : AH8

202) chain C
residue 111
type
sequence E
description binding site for residue EPE C 511
source : AH8

203) chain C
residue 327
type
sequence Q
description binding site for residue EPE C 511
source : AH8

204) chain C
residue 328
type
sequence L
description binding site for residue EPE C 511
source : AH8

205) chain C
residue 331
type
sequence Q
description binding site for residue EPE C 511
source : AH8

206) chain C
residue 115
type
sequence N
description binding site for residue EDO C 512
source : AH9

207) chain C
residue 155
type
sequence A
description binding site for residue EDO C 512
source : AH9

208) chain C
residue 162
type
sequence N
description binding site for residue EDO C 512
source : AH9

209) chain C
residue 335
type
sequence R
description binding site for residue EDO C 512
source : AH9

210) chain C
residue 277
type
sequence M
description binding site for residue EDO C 513
source : AI1

211) chain C
residue 210
type
sequence Q
description binding site for residue EDO C 514
source : AI2

212) chain C
residue 325
type
sequence P
description binding site for residue EDO C 515
source : AI3

213) chain C
residue 326
type
sequence L
description binding site for residue EDO C 515
source : AI3

214) chain C
residue 401
type
sequence D
description binding site for residue EDO C 515
source : AI3

215) chain C
residue 402
type
sequence N
description binding site for residue EDO C 515
source : AI3

216) chain D
residue 330
type
sequence R
description binding site for residue EDO C 515
source : AI3

217) chain A
residue 211
type
sequence F
description binding site for residue EDO C 516
source : AI4

218) chain A
residue 212
type
sequence L
description binding site for residue EDO C 516
source : AI4

219) chain A
residue 217
type
sequence S
description binding site for residue EDO C 516
source : AI4

220) chain C
residue 152
type
sequence H
description binding site for residue EDO C 516
source : AI4

221) chain C
residue 243
type
sequence E
description binding site for residue EDO C 516
source : AI4

222) chain C
residue 128
type
sequence E
description binding site for residue EDO C 517
source : AI5

223) chain C
residue 173
type
sequence H
description binding site for residue EDO C 517
source : AI5

224) chain C
residue 177
type
sequence S
description binding site for residue EDO C 517
source : AI5

225) chain C
residue 273
type
sequence M
description binding site for residue E8H C 518
source : AI6

226) chain C
residue 321
type
sequence N
description binding site for residue E8H C 518
source : AI6

227) chain C
residue 336
type
sequence I
description binding site for residue E8H C 518
source : AI6

228) chain C
residue 357
type
sequence M
description binding site for residue E8H C 518
source : AI6

229) chain C
residue 369
type
sequence Q
description binding site for residue E8H C 518
source : AI6

230) chain C
residue 371
type
sequence G
description binding site for residue E8H C 518
source : AI6

231) chain C
residue 372
type
sequence F
description binding site for residue E8H C 518
source : AI6

232) chain C
residue 376
type
sequence I
description binding site for residue E8H C 518
source : AI6

233) chain C
residue 223
type
sequence Y
description binding site for residue PG4 C 519
source : AI7

234) chain C
residue 231
type
sequence N
description binding site for residue PG4 C 519
source : AI7

235) chain C
residue 234
type
sequence L
description binding site for residue PG4 C 519
source : AI7

236) chain C
residue 235
type
sequence A
description binding site for residue PG4 C 519
source : AI7

237) chain C
residue 238
type
sequence F
description binding site for residue PG4 C 519
source : AI7

238) chain C
residue 261
type
sequence R
description binding site for residue PG4 C 519
source : AI7

239) chain D
residue 221
type
sequence L
description binding site for residue PG4 C 519
source : AI7

240) chain D
residue 222
type
sequence M
description binding site for residue PG4 C 519
source : AI7

241) chain D
residue 224
type
sequence N
description binding site for residue PG4 C 519
source : AI7

242) chain B
residue 349
type
sequence E
description binding site for residue EDO D 501
source : AI8

243) chain B
residue 350
type
sequence R
description binding site for residue EDO D 501
source : AI8

244) chain D
residue 140
type
sequence D
description binding site for residue EDO D 501
source : AI8

245) chain D
residue 144
type
sequence T
description binding site for residue EDO D 501
source : AI8

246) chain D
residue 147
type
sequence M
description binding site for residue EDO D 501
source : AI8

247) chain A
residue 258
type
sequence Q
description binding site for residue EDO D 502
source : AI9

248) chain B
residue 214
type
sequence N
description binding site for residue EDO D 502
source : AI9

249) chain D
residue 294
type
sequence S
description binding site for residue EDO D 502
source : AI9

250) chain D
residue 295
type
sequence S
description binding site for residue EDO D 502
source : AI9

251) chain D
residue 164
type
sequence H
description binding site for residue ZN D 503
source : AJ1

252) chain D
residue 200
type
sequence H
description binding site for residue ZN D 503
source : AJ1

253) chain D
residue 201
type
sequence D
description binding site for residue ZN D 503
source : AJ1

254) chain D
residue 318
type
sequence D
description binding site for residue ZN D 503
source : AJ1

255) chain D
residue 201
type
sequence D
description binding site for residue MG D 504
source : AJ2

256) chain A
residue 134
type
sequence T
description binding site for residue EDO D 505
source : AJ3

257) chain A
residue 135
type
sequence F
description binding site for residue EDO D 505
source : AJ3

258) chain A
residue 251
type
sequence N
description binding site for residue EDO D 505
source : AJ3

259) chain A
residue 256
type
sequence Q
description binding site for residue EDO D 505
source : AJ3

260) chain D
residue 391
type
sequence D
description binding site for residue EDO D 505
source : AJ3

261) chain D
residue 259
type
sequence S
description binding site for residue EDO D 506
source : AJ4

262) chain D
residue 303
type
sequence Y
description binding site for residue EDO D 506
source : AJ4

263) chain D
residue 208
type
sequence S
description binding site for residue EDO D 507
source : AJ5

264) chain D
residue 356
type
sequence P
description binding site for residue EDO D 507
source : AJ5

265) chain D
residue 238
type
sequence F
description binding site for residue EDO D 508
source : AJ6

266) chain D
residue 249
type
sequence F
description binding site for residue EDO D 508
source : AJ6

267) chain D
residue 257
type
sequence R
description binding site for residue EDO D 508
source : AJ6

268) chain D
residue 261
type
sequence R
description binding site for residue EDO D 508
source : AJ6

269) chain B
residue 156
type
sequence D
description binding site for residue PEG D 509
source : AJ7

270) chain D
residue 116
type
sequence R
description binding site for residue PEG D 509
source : AJ7

271) chain D
residue 150
type
sequence E
description binding site for residue PEG D 509
source : AJ7

272) chain D
residue 151
type
sequence D
description binding site for residue PEG D 509
source : AJ7

273) chain D
residue 153
type
sequence Y
description binding site for residue PEG D 509
source : AJ7

274) chain D
residue 154
type
sequence H
description binding site for residue PEG D 509
source : AJ7

275) chain D
residue 155
type
sequence A
description binding site for residue PEG D 509
source : AJ7

276) chain A
residue 256
type
sequence Q
description binding site for residue EDO D 510
source : AJ8

277) chain A
residue 259
type
sequence S
description binding site for residue EDO D 510
source : AJ8

278) chain D
residue 182
type
sequence E
description binding site for residue EDO D 510
source : AJ8

279) chain B
residue 215
type
sequence T
description binding site for residue EDO D 511
source : AJ9

280) chain D
residue 148
type
sequence T
description binding site for residue EDO D 511
source : AJ9

281) chain D
residue 152
type
sequence H
description binding site for residue EDO D 511
source : AJ9

282) chain D
residue 243
type
sequence E
description binding site for residue EDO D 511
source : AJ9

283) chain D
residue 262
type
sequence K
description binding site for residue EDO D 512
source : AK1

284) chain D
residue 265
type
sequence I
description binding site for residue EDO D 512
source : AK1

285) chain D
residue 266
type
sequence D
description binding site for residue EDO D 512
source : AK1

286) chain D
residue 174
type
sequence V
description binding site for residue EDO D 513
source : AK2

287) chain D
residue 178
type
sequence T
description binding site for residue EDO D 513
source : AK2

288) chain D
residue 384
type
sequence W
description binding site for residue EDO D 513
source : AK2

289) chain D
residue 98
type
sequence D
description binding site for residue EDO D 514
source : AK3

290) chain D
residue 101
type
sequence K
description binding site for residue EDO D 514
source : AK3

291) chain D
residue 102
type
sequence W
description binding site for residue EDO D 514
source : AK3

292) chain D
residue 103
type
sequence G
description binding site for residue EDO D 514
source : AK3

293) chain D
residue 105
type
sequence H
description binding site for residue EDO D 514
source : AK3

294) chain D
residue 115
type
sequence N
description binding site for residue EDO D 515
source : AK4

295) chain D
residue 155
type
sequence A
description binding site for residue EDO D 515
source : AK4

296) chain D
residue 162
type
sequence N
description binding site for residue EDO D 515
source : AK4

297) chain D
residue 105
type
sequence H
description binding site for residue EPE D 516
source : AK5

298) chain D
residue 106
type
sequence V
description binding site for residue EPE D 516
source : AK5

299) chain D
residue 107
type
sequence F
description binding site for residue EPE D 516
source : AK5

300) chain D
residue 108
type
sequence R
description binding site for residue EPE D 516
source : AK5

301) chain D
residue 111
type
sequence E
description binding site for residue EPE D 516
source : AK5

302) chain D
residue 327
type
sequence Q
description binding site for residue EPE D 516
source : AK5

303) chain D
residue 328
type
sequence L
description binding site for residue EPE D 516
source : AK5

304) chain D
residue 331
type
sequence Q
description binding site for residue EPE D 516
source : AK5

305) chain D
residue 266
type
sequence D
description binding site for residue EDO D 517
source : AK6

306) chain D
residue 269
type
sequence L
description binding site for residue EDO D 517
source : AK6

307) chain D
residue 270
type
sequence A
description binding site for residue EDO D 517
source : AK6

308) chain D
residue 311
type
sequence Q
description binding site for residue EDO D 517
source : AK6

309) chain D
residue 273
type
sequence M
description binding site for residue E8H D 518
source : AK7

310) chain D
residue 321
type
sequence N
description binding site for residue E8H D 518
source : AK7

311) chain D
residue 336
type
sequence I
description binding site for residue E8H D 518
source : AK7

312) chain D
residue 357
type
sequence M
description binding site for residue E8H D 518
source : AK7

313) chain D
residue 368
type
sequence S
description binding site for residue E8H D 518
source : AK7

314) chain D
residue 369
type
sequence Q
description binding site for residue E8H D 518
source : AK7

315) chain D
residue 372
type
sequence F
description binding site for residue E8H D 518
source : AK7

316) chain A
residue 200-211
type prosite
sequence HDVDHPGVSNQF
description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF
source prosite : PS00126

317) chain A
residue 160
type ACT_SITE
sequence H
description Proton donor => ECO:0000250|UniProtKB:Q07343
source Swiss-Prot : SWS_FT_FI1

318) chain B
residue 160
type ACT_SITE
sequence H
description Proton donor => ECO:0000250|UniProtKB:Q07343
source Swiss-Prot : SWS_FT_FI1

319) chain C
residue 160
type ACT_SITE
sequence H
description Proton donor => ECO:0000250|UniProtKB:Q07343
source Swiss-Prot : SWS_FT_FI1

320) chain D
residue 160
type ACT_SITE
sequence H
description Proton donor => ECO:0000250|UniProtKB:Q07343
source Swiss-Prot : SWS_FT_FI1

321) chain A
residue 160
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

322) chain D
residue 160
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

323) chain D
residue 321
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

324) chain D
residue 369
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

325) chain A
residue 321
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

326) chain A
residue 369
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

327) chain B
residue 160
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

328) chain B
residue 321
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

329) chain B
residue 369
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

330) chain C
residue 160
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

331) chain C
residue 321
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

332) chain C
residue 369
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7
source Swiss-Prot : SWS_FT_FI2

333) chain A
residue 164
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI3

334) chain B
residue 164
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI3

335) chain C
residue 164
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI3

336) chain D
residue 164
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI3

337) chain A
residue 200
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

338) chain A
residue 318
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

339) chain B
residue 200
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

340) chain B
residue 318
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

341) chain C
residue 200
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

342) chain C
residue 318
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

343) chain D
residue 200
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

344) chain D
residue 318
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3
source Swiss-Prot : SWS_FT_FI4

345) chain A
residue 201
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

346) chain A
residue 372
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

347) chain B
residue 201
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

348) chain B
residue 372
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

349) chain C
residue 201
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

350) chain C
residue 372
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

351) chain D
residue 201
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

352) chain D
residue 372
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW
source Swiss-Prot : SWS_FT_FI5

353) chain A
residue 85
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
source Swiss-Prot : SWS_FT_FI6


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