eF-site ID 6fv9-B PDB Code 6fv9 Chain B click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-007 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence B:  VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPL DVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRN VPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLIT ALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHH CNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISN VTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRS KNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIK SNRAQWERVLET Description Functional site 1) chain B residue 849 type sequence D description binding site for residue GOL A 1004 source : AC4 2) chain B residue 864 type sequence R description binding site for residue GOL A 1004 source : AC4 3) chain B residue 710 type sequence D description binding site for residue MG B 1001 source : AC7 4) chain B residue 673 type sequence H description binding site for residue ZN B 1002 source : AC8 5) chain B residue 709 type sequence H description binding site for residue ZN B 1002 source : AC8 6) chain B residue 710 type sequence D description binding site for residue ZN B 1002 source : AC8 7) chain B residue 822 type sequence D description binding site for residue ZN B 1002 source : AC8 8) chain B residue 688 type sequence G description binding site for residue GOL B 1003 source : AC9 9) chain B residue 689 type sequence N description binding site for residue GOL B 1003 source : AC9 10) chain B residue 692 type sequence E description binding site for residue GOL B 1003 source : AC9 11) chain B residue 894 type sequence L description binding site for residue GOL B 1003 source : AC9 12) chain B residue 895 type sequence Q description binding site for residue GOL B 1003 source : AC9 13) chain B residue 896 type sequence G description binding site for residue GOL B 1003 source : AC9 14) chain B residue 785 type sequence M description binding site for residue E8H B 1004 source : AD1 15) chain B residue 823 type sequence I description binding site for residue E8H B 1004 source : AD1 16) chain B residue 825 type sequence N description binding site for residue E8H B 1004 source : AD1 17) chain B residue 837 type sequence A description binding site for residue E8H B 1004 source : AD1 18) chain B residue 861 type sequence M description binding site for residue E8H B 1004 source : AD1 19) chain B residue 873 type sequence G description binding site for residue E8H B 1004 source : AD1 20) chain B residue 874 type sequence Q description binding site for residue E8H B 1004 source : AD1

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