eF-site ID 6fv2-C PDB Code 6fv2 Chain C click to enlarge Title Structure of human coronavirus NL63 main protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (cinnamoyl-phenylalanine-GlnLactam-CO-CO-NH-benzyl) Classification HYDROLASE Compound 3C-like proteinase Source (R1AB_CVHNL) Sequence C:  SGLKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPR HVIAPSTTVLIDYDHAYSTMRLHNFSVSHNGVFLGVVGVT MHGSVLRIKVSQSNVHTPKHVFKTLKPGDSFNILACYEGI ASGVFGVNLRTNFTIKGSFINGACGSPGYNVRNDGTVEFC YLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESANLML SDNVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYT SVSSVECYSILAAKTGVSVEQLLASIQHLHEGFGGKNILG YSSLCDEFTLAEVVKQMYG Description (1)  Replicase polyprotein 1ab (E.C.3.4.19.12,3.4.22.69,3.4.22.-,2.7.7.48,3.6.4.12,3.6.4.13,2.1.1.-,3.1.13.-,3.1.-.-) Functional site 1) chain C residue 5 type sequence K description binding site for residue GOL C 401 source : AC4 2) chain C residue 6 type sequence M description binding site for residue GOL C 401 source : AC4 3) chain C residue 8 type sequence Q description binding site for residue GOL C 401 source : AC4 4) chain C residue 110 type sequence S description binding site for residue GOL C 401 source : AC4 5) chain C residue 111 type sequence F description binding site for residue GOL C 401 source : AC4 6) chain C residue 112 type sequence N description binding site for residue GOL C 401 source : AC4 7) chain C residue 126 type sequence G description binding site for residue GOL C 401 source : AC4 8) chain C residue 150 type sequence N description binding site for residue GOL C 401 source : AC4 9) chain C residue 292 type sequence E description binding site for residue GOL C 401 source : AC4 10) chain C residue 26 type sequence V description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 11) chain C residue 27 type sequence L description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 12) chain C residue 28 type sequence N description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 13) chain C residue 41 type sequence H description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 14) chain C residue 47 type sequence T description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 15) chain C residue 51 type sequence I description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 16) chain C residue 53 type sequence Y description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 17) chain C residue 139 type sequence F description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 18) chain C residue 140 type sequence I description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 19) chain C residue 141 type sequence N description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 20) chain C residue 142 type sequence G description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 21) chain C residue 143 type sequence A description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 22) chain C residue 145 type sequence G description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 23) chain C residue 146 type sequence S description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 24) chain C residue 163 type sequence H description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 25) chain C residue 164 type sequence Q description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 26) chain C residue 165 type sequence I description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 27) chain C residue 166 type sequence E description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 28) chain C residue 187 type sequence D description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 29) chain C residue 190 type sequence S description binding site for Di-peptide D03 C 402 and CYS C 144 source : AC6 30) chain C residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 31) chain C residue 144 type ACT_SITE sequence C description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1

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