eF-site ID 6fv2-A PDB Code 6fv2 Chain A click to enlarge Title Structure of human coronavirus NL63 main protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (cinnamoyl-phenylalanine-GlnLactam-CO-CO-NH-benzyl) Classification HYDROLASE Compound 3C-like proteinase Source (R1AB_CVHNL) Sequence A:  SGLKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPR HVIAPSTTVLIDYDHAYSTMRLHNFSVSHNGVFLGVVGVT MHGSVLRIKVSQSNVHTPKHVFKTLKPGDSFNILACYEGI ASGVFGVNLRTNFTIKGSFINGACGSPGYNVRNDGTVEFC YLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESANLML SDNVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYT SVSSVECYSILAAKTGVSVEQLLASIQHLHEGFGGKNILG YSSLCDEFTLAEVVKQMYGVN Description Functional site 1) chain A residue 6 type sequence M description binding site for residue GOL A 401 source : AC1 2) chain A residue 117 type sequence Y description binding site for residue GOL A 401 source : AC1 3) chain A residue 122 type sequence S description binding site for residue GOL A 401 source : AC1 4) chain A residue 138 type sequence S description binding site for residue GOL A 401 source : AC1 5) chain A residue 295 type sequence K description binding site for residue GOL A 401 source : AC1 6) chain A residue 26 type sequence V description binding site for residue D03 A 402 source : AC2 7) chain A residue 41 type sequence H description binding site for residue D03 A 402 source : AC2 8) chain A residue 51 type sequence I description binding site for residue D03 A 402 source : AC2 9) chain A residue 53 type sequence Y description binding site for residue D03 A 402 source : AC2 10) chain A residue 139 type sequence F description binding site for residue D03 A 402 source : AC2 11) chain A residue 141 type sequence N description binding site for residue D03 A 402 source : AC2 12) chain A residue 142 type sequence G description binding site for residue D03 A 402 source : AC2 13) chain A residue 143 type sequence A description binding site for residue D03 A 402 source : AC2 14) chain A residue 144 type sequence C description binding site for residue D03 A 402 source : AC2 15) chain A residue 163 type sequence H description binding site for residue D03 A 402 source : AC2 16) chain A residue 164 type sequence Q description binding site for residue D03 A 402 source : AC2 17) chain A residue 165 type sequence I description binding site for residue D03 A 402 source : AC2 18) chain A residue 166 type sequence E description binding site for residue D03 A 402 source : AC2 19) chain A residue 187 type sequence D description binding site for residue D03 A 402 source : AC2 20) chain A residue 188 type sequence Q description binding site for residue D03 A 402 source : AC2 21) chain A residue 190 type sequence S description binding site for residue D03 A 402 source : AC2 22) chain A residue 192 type sequence Q description binding site for residue D03 A 402 source : AC2 23) chain A residue 224 type sequence R description binding site for residue GOL B 401 source : AC3 24) chain A residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 144 type ACT_SITE sequence C description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1

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