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eF-site ID
|
6fuj-E |
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PDB Code
|
6fuj |
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Chain
|
E |
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click to enlarge
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Title
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Complement factor D in complex with the inhibitor N-(3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)-3-methylbutanamide |
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Classification
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HYDROLASE |
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Compound
|
Complement factor D |
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Source
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(CFAD_HUMAN) |
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Sequence
|
E: |
ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA
HCLGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDT
IDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDV
AGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAIT
ERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCG
NRKKPGIYTRVASYAAWIDSVLA
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Description
|
(1) |
Complement factor D (E.C.3.4.21.46)
|
|
Functional site
|
|
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1)
|
chain |
E |
| residue |
57 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
E |
| residue |
102 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
E |
| residue |
195 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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