eF-site ID 6fuj-ABCDEF PDB Code 6fuj Chain A, B, C, D, E, F click to enlarge Title Complement factor D in complex with the inhibitor N-(3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)-3-methylbutanamide Classification HYDROLASE Compound Complement factor D Source (CFAD_HUMAN) Sequence A:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVLA B:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVLA C:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVLA D:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVLA E:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDT IDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDV AGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAIT ERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCG NRKKPGIYTRVASYAAWIDSVLA F:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVLA Description (1)  Complement factor D (E.C.3.4.21.46) Functional site 1) chain A residue 96 type sequence P description binding site for residue E8B A 301 source : AC1 2) chain A residue 189 type sequence D description binding site for residue E8B A 301 source : AC1 3) chain A residue 190 type sequence S description binding site for residue E8B A 301 source : AC1 4) chain A residue 191 type sequence C description binding site for residue E8B A 301 source : AC1 5) chain A residue 192 type sequence K description binding site for residue E8B A 301 source : AC1 6) chain A residue 195 type sequence S description binding site for residue E8B A 301 source : AC1 7) chain A residue 215 type sequence S description binding site for residue E8B A 301 source : AC1 8) chain A residue 218 type sequence R description binding site for residue E8B A 301 source : AC1 9) chain A residue 218 type sequence R description binding site for residue E8B A 301 source : AC1 10) chain A residue 219 type sequence V description binding site for residue E8B A 301 source : AC1 11) chain B residue 41 type sequence L description binding site for residue E8B B 301 source : AC2 12) chain B residue 57 type sequence H description binding site for residue E8B B 301 source : AC2 13) chain B residue 58 type sequence C description binding site for residue E8B B 301 source : AC2 14) chain B residue 189 type sequence D description binding site for residue E8B B 301 source : AC2 15) chain B residue 190 type sequence S description binding site for residue E8B B 301 source : AC2 16) chain B residue 191 type sequence C description binding site for residue E8B B 301 source : AC2 17) chain B residue 192 type sequence K description binding site for residue E8B B 301 source : AC2 18) chain B residue 195 type sequence S description binding site for residue E8B B 301 source : AC2 19) chain B residue 215 type sequence S description binding site for residue E8B B 301 source : AC2 20) chain B residue 218 type sequence R description binding site for residue E8B B 301 source : AC2 21) chain B residue 219 type sequence V description binding site for residue E8B B 301 source : AC2 22) chain B residue 220 type sequence C description binding site for residue E8B B 301 source : AC2 23) chain C residue 61 type sequence D description binding site for residue E8B B 301 source : AC2 24) chain C residue 96 type sequence P description binding site for residue E8B B 301 source : AC2 25) chain C residue 218 type sequence R description binding site for residue E8B B 301 source : AC2 26) chain B residue 61 type sequence D description binding site for residue E8B C 301 source : AC3 27) chain B residue 96 type sequence P description binding site for residue E8B C 301 source : AC3 28) chain B residue 218 type sequence R description binding site for residue E8B C 301 source : AC3 29) chain C residue 57 type sequence H description binding site for residue E8B C 301 source : AC3 30) chain C residue 189 type sequence D description binding site for residue E8B C 301 source : AC3 31) chain C residue 190 type sequence S description binding site for residue E8B C 301 source : AC3 32) chain C residue 191 type sequence C description binding site for residue E8B C 301 source : AC3 33) chain C residue 192 type sequence K description binding site for residue E8B C 301 source : AC3 34) chain C residue 195 type sequence S description binding site for residue E8B C 301 source : AC3 35) chain C residue 215 type sequence S description binding site for residue E8B C 301 source : AC3 36) chain C residue 218 type sequence R description binding site for residue E8B C 301 source : AC3 37) chain C residue 219 type sequence V description binding site for residue E8B C 301 source : AC3 38) chain A residue 53-58 type prosite sequence LSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC source prosite : PS00134 39) chain A residue 189-200 type prosite sequence DSCKGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV source prosite : PS00135 40) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 41) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 42) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 43) chain B residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 44) chain B residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 45) chain B residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 46) chain C residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 47) chain C residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 48) chain C residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 49) chain D residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 50) chain D residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 51) chain D residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 52) chain E residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 53) chain E residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 54) chain E residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 55) chain F residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 56) chain F residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 57) chain F residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1

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