eF-site ID 6fui-A PDB Code 6fui Chain A click to enlarge Title Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol Classification HYDROLASE Compound Complement factor D Source (CFAD_HUMAN) Sequence A:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVL Description (1)  Complement factor D (E.C.3.4.21.46) Functional site 1) chain A residue 57 type sequence H description binding site for residue E7W A 301 source : AC1 2) chain A residue 58 type sequence C description binding site for residue E7W A 301 source : AC1 3) chain A residue 189 type sequence D description binding site for residue E7W A 301 source : AC1 4) chain A residue 190 type sequence S description binding site for residue E7W A 301 source : AC1 5) chain A residue 191 type sequence C description binding site for residue E7W A 301 source : AC1 6) chain A residue 192 type sequence K description binding site for residue E7W A 301 source : AC1 7) chain A residue 193 type sequence G description binding site for residue E7W A 301 source : AC1 8) chain A residue 195 type sequence S description binding site for residue E7W A 301 source : AC1 9) chain A residue 214 type sequence T description binding site for residue E7W A 301 source : AC1 10) chain A residue 215 type sequence S description binding site for residue E7W A 301 source : AC1 11) chain A residue 217 type sequence S description binding site for residue E7W A 301 source : AC1 12) chain A residue 218 type sequence R description binding site for residue E7W A 301 source : AC1 13) chain A residue 219 type sequence V description binding site for residue E7W A 301 source : AC1 14) chain A residue 220 type sequence C description binding site for residue E7W A 301 source : AC1 15) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 16) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 17) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 18) chain A residue 53-58 type prosite sequence LSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC source prosite : PS00134 19) chain A residue 189-200 type prosite sequence DSCKGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV source prosite : PS00135

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