eF-site ID 6frd-B PDB Code 6frd Chain B click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-637 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence B:  TAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLD VAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRNV PYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITA LVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHHC NLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDMA KHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNV TKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRSK NMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIKS NRAQWERVLET Description Functional site 1) chain B residue 696 type sequence E description binding site for residue GAI A 1005 source : AC5 2) chain B residue 644 type sequence K description binding site for residue GAI A 1008 source : AC8 3) chain B residue 696 type sequence E description binding site for residue GAI A 1008 source : AC8 4) chain B residue 673 type sequence H description binding site for residue ZN B 1001 source : AC9 5) chain B residue 709 type sequence H description binding site for residue ZN B 1001 source : AC9 6) chain B residue 710 type sequence D description binding site for residue ZN B 1001 source : AC9 7) chain B residue 822 type sequence D description binding site for residue ZN B 1001 source : AC9 8) chain B residue 710 type sequence D description binding site for residue MG B 1002 source : AD1 9) chain B residue 688 type sequence G description binding site for residue GAI B 1003 source : AD2 10) chain B residue 689 type sequence N description binding site for residue GAI B 1003 source : AD2 11) chain B residue 692 type sequence E description binding site for residue GAI B 1003 source : AD2 12) chain B residue 693 type sequence K description binding site for residue GAI B 1003 source : AD2 13) chain B residue 894 type sequence L description binding site for residue GAI B 1003 source : AD2 14) chain B residue 896 type sequence G description binding site for residue GAI B 1003 source : AD2 15) chain B residue 696 type sequence E description binding site for residue GAI B 1004 source : AD3 16) chain B residue 753 type sequence L description binding site for residue GAI B 1005 source : AD4 17) chain B residue 754 type sequence S description binding site for residue GAI B 1005 source : AD4 18) chain B residue 755 type sequence D description binding site for residue GAI B 1005 source : AD4 19) chain B residue 756 type sequence P description binding site for residue GAI B 1005 source : AD4 20) chain B residue 759 type sequence D description binding site for residue GAI B 1005 source : AD4 21) chain B residue 762 type sequence D description binding site for residue GAI B 1005 source : AD4 22) chain B residue 785 type sequence M description binding site for residue E3Q B 1006 source : AD5 23) chain B residue 825 type sequence N description binding site for residue E3Q B 1006 source : AD5 24) chain B residue 840 type sequence V description binding site for residue E3Q B 1006 source : AD5 25) chain B residue 841 type sequence T description binding site for residue E3Q B 1006 source : AD5 26) chain B residue 861 type sequence M description binding site for residue E3Q B 1006 source : AD5 27) chain B residue 870 type sequence L description binding site for residue E3Q B 1006 source : AD5 28) chain B residue 873 type sequence G description binding site for residue E3Q B 1006 source : AD5 29) chain B residue 874 type sequence Q description binding site for residue E3Q B 1006 source : AD5 30) chain B residue 877 type sequence F description binding site for residue E3Q B 1006 source : AD5

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