eF-site ID 6frd-AB PDB Code 6frd Chain A, B click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-637 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence A:  TAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLD VAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRNV PYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITA LVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHHC NLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDMA KHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNV TKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRSK NMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIKS NRAQWERVLETR B:  TAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLD VAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRNV PYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITA LVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHHC NLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDMA KHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNV TKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRSK NMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIKS NRAQWERVLET Description Functional site 1) chain A residue 673 type sequence H description binding site for residue ZN A 1001 source : AC1 2) chain A residue 709 type sequence H description binding site for residue ZN A 1001 source : AC1 3) chain A residue 710 type sequence D description binding site for residue ZN A 1001 source : AC1 4) chain A residue 822 type sequence D description binding site for residue ZN A 1001 source : AC1 5) chain A residue 710 type sequence D description binding site for residue MG A 1002 source : AC2 6) chain A residue 688 type sequence G description binding site for residue GAI A 1003 source : AC3 7) chain A residue 693 type sequence K description binding site for residue GAI A 1003 source : AC3 8) chain A residue 893 type sequence C description binding site for residue GAI A 1003 source : AC3 9) chain A residue 894 type sequence L description binding site for residue GAI A 1003 source : AC3 10) chain A residue 896 type sequence G description binding site for residue GAI A 1003 source : AC3 11) chain A residue 753 type sequence L description binding site for residue GAI A 1004 source : AC4 12) chain A residue 754 type sequence S description binding site for residue GAI A 1004 source : AC4 13) chain A residue 759 type sequence D description binding site for residue GAI A 1004 source : AC4 14) chain A residue 762 type sequence D description binding site for residue GAI A 1004 source : AC4 15) chain A residue 769 type sequence R description binding site for residue GAI A 1004 source : AC4 16) chain A residue 915 type sequence L description binding site for residue GAI A 1004 source : AC4 17) chain A residue 639 type sequence S description binding site for residue GAI A 1005 source : AC5 18) chain A residue 641 type sequence L description binding site for residue GAI A 1005 source : AC5 19) chain A residue 644 type sequence K description binding site for residue GAI A 1005 source : AC5 20) chain A residue 686 type sequence Y description binding site for residue GAI A 1005 source : AC5 21) chain B residue 696 type sequence E description binding site for residue GAI A 1005 source : AC5 22) chain A residue 686 type sequence Y description binding site for residue FMT A 1006 source : AC6 23) chain A residue 689 type sequence N description binding site for residue FMT A 1006 source : AC6 24) chain A residue 778 type sequence D description binding site for residue FMT A 1007 source : AC7 25) chain A residue 639 type sequence S description binding site for residue GAI A 1008 source : AC8 26) chain A residue 682 type sequence H description binding site for residue GAI A 1008 source : AC8 27) chain A residue 686 type sequence Y description binding site for residue GAI A 1008 source : AC8 28) chain B residue 644 type sequence K description binding site for residue GAI A 1008 source : AC8 29) chain B residue 696 type sequence E description binding site for residue GAI A 1008 source : AC8 30) chain B residue 673 type sequence H description binding site for residue ZN B 1001 source : AC9 31) chain B residue 709 type sequence H description binding site for residue ZN B 1001 source : AC9 32) chain B residue 710 type sequence D description binding site for residue ZN B 1001 source : AC9 33) chain B residue 822 type sequence D description binding site for residue ZN B 1001 source : AC9 34) chain B residue 710 type sequence D description binding site for residue MG B 1002 source : AD1 35) chain B residue 688 type sequence G description binding site for residue GAI B 1003 source : AD2 36) chain B residue 689 type sequence N description binding site for residue GAI B 1003 source : AD2 37) chain B residue 692 type sequence E description binding site for residue GAI B 1003 source : AD2 38) chain B residue 693 type sequence K description binding site for residue GAI B 1003 source : AD2 39) chain B residue 894 type sequence L description binding site for residue GAI B 1003 source : AD2 40) chain B residue 896 type sequence G description binding site for residue GAI B 1003 source : AD2 41) chain A residue 691 type sequence Y description binding site for residue GAI B 1004 source : AD3 42) chain B residue 696 type sequence E description binding site for residue GAI B 1004 source : AD3 43) chain B residue 753 type sequence L description binding site for residue GAI B 1005 source : AD4 44) chain B residue 754 type sequence S description binding site for residue GAI B 1005 source : AD4 45) chain B residue 755 type sequence D description binding site for residue GAI B 1005 source : AD4 46) chain B residue 756 type sequence P description binding site for residue GAI B 1005 source : AD4 47) chain B residue 759 type sequence D description binding site for residue GAI B 1005 source : AD4 48) chain B residue 762 type sequence D description binding site for residue GAI B 1005 source : AD4 49) chain B residue 785 type sequence M description binding site for residue E3Q B 1006 source : AD5 50) chain B residue 825 type sequence N description binding site for residue E3Q B 1006 source : AD5 51) chain B residue 840 type sequence V description binding site for residue E3Q B 1006 source : AD5 52) chain B residue 841 type sequence T description binding site for residue E3Q B 1006 source : AD5 53) chain B residue 861 type sequence M description binding site for residue E3Q B 1006 source : AD5 54) chain B residue 870 type sequence L description binding site for residue E3Q B 1006 source : AD5 55) chain B residue 873 type sequence G description binding site for residue E3Q B 1006 source : AD5 56) chain B residue 874 type sequence Q description binding site for residue E3Q B 1006 source : AD5 57) chain B residue 877 type sequence F description binding site for residue E3Q B 1006 source : AD5 58) chain A residue 709-720 type prosite sequence HDLDHMGLNNSF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF source prosite : PS00126

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