eF-site ID 6frd-A PDB Code 6frd Chain A click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-637 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence A:  TAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLD VAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRNV PYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITA LVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHHC NLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDMA KHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNV TKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRSK NMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIKS NRAQWERVLETR Description Functional site 1) chain A residue 673 type sequence H description binding site for residue ZN A 1001 source : AC1 2) chain A residue 709 type sequence H description binding site for residue ZN A 1001 source : AC1 3) chain A residue 710 type sequence D description binding site for residue ZN A 1001 source : AC1 4) chain A residue 822 type sequence D description binding site for residue ZN A 1001 source : AC1 5) chain A residue 710 type sequence D description binding site for residue MG A 1002 source : AC2 6) chain A residue 688 type sequence G description binding site for residue GAI A 1003 source : AC3 7) chain A residue 693 type sequence K description binding site for residue GAI A 1003 source : AC3 8) chain A residue 893 type sequence C description binding site for residue GAI A 1003 source : AC3 9) chain A residue 894 type sequence L description binding site for residue GAI A 1003 source : AC3 10) chain A residue 896 type sequence G description binding site for residue GAI A 1003 source : AC3 11) chain A residue 753 type sequence L description binding site for residue GAI A 1004 source : AC4 12) chain A residue 754 type sequence S description binding site for residue GAI A 1004 source : AC4 13) chain A residue 759 type sequence D description binding site for residue GAI A 1004 source : AC4 14) chain A residue 762 type sequence D description binding site for residue GAI A 1004 source : AC4 15) chain A residue 769 type sequence R description binding site for residue GAI A 1004 source : AC4 16) chain A residue 915 type sequence L description binding site for residue GAI A 1004 source : AC4 17) chain A residue 639 type sequence S description binding site for residue GAI A 1005 source : AC5 18) chain A residue 641 type sequence L description binding site for residue GAI A 1005 source : AC5 19) chain A residue 644 type sequence K description binding site for residue GAI A 1005 source : AC5 20) chain A residue 686 type sequence Y description binding site for residue GAI A 1005 source : AC5 21) chain A residue 686 type sequence Y description binding site for residue FMT A 1006 source : AC6 22) chain A residue 689 type sequence N description binding site for residue FMT A 1006 source : AC6 23) chain A residue 778 type sequence D description binding site for residue FMT A 1007 source : AC7 24) chain A residue 639 type sequence S description binding site for residue GAI A 1008 source : AC8 25) chain A residue 682 type sequence H description binding site for residue GAI A 1008 source : AC8 26) chain A residue 686 type sequence Y description binding site for residue GAI A 1008 source : AC8 27) chain A residue 691 type sequence Y description binding site for residue GAI B 1004 source : AD3 28) chain A residue 709-720 type prosite sequence HDLDHMGLNNSF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF source prosite : PS00126

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