eF-site ID 6fko-AB PDB Code 6fko Chain A, B click to enlarge Title Deoxyguanylosuccinate synthase (DgsS) quaternary structure with ATP, dGMP, hadacidin at 2.1 Angstrom resolution Classification BIOSYNTHETIC PROTEIN Compound Adenylosuccinate synthetase Source (G3FFN6_9CAUD) Sequence A:  MENVDLVIDLQFGSTGKGLIAGYLAEKNGYDTVINANMPN AGHTYINAEGRKWMHKVLPNGIVSPNLKRVMLGAGSVFSI NRLMEEIEMSKDLLHDKVAILIHPMATVLDEEAHKKAEVG IATSIGSTGQGSMAAMVEKLQRDPTNNTIVARDVAQYDGR IAQYVCTVEEWDMALMASERILAEGAQGFSLSLNQEFYPY CTSRDCTPARFLADMGIPLPMLNKVIGTARCHPIRVGGTS GGHYPDQEELTWEQLGQVPELTTVTKKVRRVFSFSFIQMQ KAMWTCQPDEVFLNFCNYLSPMGWQDIVHQIEVAAQSRYC DAEVKYLGFGPTFNDVELREDVM B:  MENVDLVIDLQFGSTGKGLIAGYLAEKNGYDTVINANMPN AGHTYINAEGRKWMHKVLPNGIVSPNLKRVMLGAGSVFSI NRLMEEIEMSKDLLHDKVAILIHPMATVLDEEAHKKAEVG IATSIGSTGQGSMAAMVEKLQRDPTNNTIVARDVAQYDGR IAQYVCTVEEWDMALMASERILAEGAQGFSLSLNQEFYPY CTSRDCTPARFLADMGIPLPMLNKVIGTARCHPIRVGGTS GGHYPDQEELTWEQLGQVPELTTVTKKVRRVFSFSFIQMQ KAMWTCQPDEVFLNFCNYLSPMGWQDIVHQIEVAAQSRYC DAEVKYLGFGPTFNDVELREDVM Description (1)  Adenylosuccinate synthetase Functional site 1) chain A residue 41 type sequence A description binding site for residue HDA A 401 source : AC1 2) chain A residue 262 type sequence T description binding site for residue HDA A 401 source : AC1 3) chain A residue 263 type sequence T description binding site for residue HDA A 401 source : AC1 4) chain A residue 264 type sequence V description binding site for residue HDA A 401 source : AC1 5) chain A residue 269 type sequence R description binding site for residue HDA A 401 source : AC1 6) chain A residue 14 type sequence S description binding site for residue DGP A 402 source : AC2 7) chain A residue 40 type sequence N description binding site for residue DGP A 402 source : AC2 8) chain A residue 41 type sequence A description binding site for residue DGP A 402 source : AC2 9) chain A residue 126 type sequence G description binding site for residue DGP A 402 source : AC2 10) chain A residue 127 type sequence S description binding site for residue DGP A 402 source : AC2 11) chain A residue 128 type sequence T description binding site for residue DGP A 402 source : AC2 12) chain A residue 187 type sequence Q description binding site for residue DGP A 402 source : AC2 13) chain A residue 191 type sequence L description binding site for residue DGP A 402 source : AC2 14) chain A residue 201 type sequence C description binding site for residue DGP A 402 source : AC2 15) chain A residue 202 type sequence T description binding site for residue DGP A 402 source : AC2 16) chain A residue 236 type sequence V description binding site for residue DGP A 402 source : AC2 17) chain B residue 142 type sequence R description binding site for residue DGP A 402 source : AC2 18) chain A residue 24 type sequence L description binding site for residue FLC A 403 source : AC3 19) chain A residue 27 type sequence K description binding site for residue FLC A 403 source : AC3 20) chain A residue 28 type sequence N description binding site for residue FLC A 403 source : AC3 21) chain A residue 180 type sequence R description binding site for residue FLC A 403 source : AC3 22) chain A residue 224 type sequence K description binding site for residue FLC A 403 source : AC3 23) chain A residue 290 type sequence E description binding site for residue FLC A 403 source : AC3 24) chain A residue 325 type sequence K description binding site for residue FLC A 403 source : AC3 25) chain A residue 326 type sequence Y description binding site for residue FLC A 403 source : AC3 26) chain A residue 14 type sequence S description binding site for residue ATP A 404 source : AC4 27) chain A residue 15 type sequence T description binding site for residue ATP A 404 source : AC4 28) chain A residue 16 type sequence G description binding site for residue ATP A 404 source : AC4 29) chain A residue 17 type sequence K description binding site for residue ATP A 404 source : AC4 30) chain A residue 18 type sequence G description binding site for residue ATP A 404 source : AC4 31) chain A residue 41 type sequence A description binding site for residue ATP A 404 source : AC4 32) chain A residue 42 type sequence G description binding site for residue ATP A 404 source : AC4 33) chain A residue 43 type sequence H description binding site for residue ATP A 404 source : AC4 34) chain A residue 44 type sequence T description binding site for residue ATP A 404 source : AC4 35) chain A residue 187 type sequence Q description binding site for residue ATP A 404 source : AC4 36) chain A residue 294 type sequence N description binding site for residue ATP A 404 source : AC4 37) chain A residue 295 type sequence F description binding site for residue ATP A 404 source : AC4 38) chain A residue 297 type sequence N description binding site for residue ATP A 404 source : AC4 39) chain A residue 330 type sequence G description binding site for residue ATP A 404 source : AC4 40) chain A residue 331 type sequence P description binding site for residue ATP A 404 source : AC4 41) chain A residue 142 type sequence R description binding site for residue DGP B 401 source : AC5 42) chain B residue 12 type sequence F description binding site for residue DGP B 401 source : AC5 43) chain B residue 14 type sequence S description binding site for residue DGP B 401 source : AC5 44) chain B residue 40 type sequence N description binding site for residue DGP B 401 source : AC5 45) chain B residue 41 type sequence A description binding site for residue DGP B 401 source : AC5 46) chain B residue 126 type sequence G description binding site for residue DGP B 401 source : AC5 47) chain B residue 127 type sequence S description binding site for residue DGP B 401 source : AC5 48) chain B residue 128 type sequence T description binding site for residue DGP B 401 source : AC5 49) chain B residue 187 type sequence Q description binding site for residue DGP B 401 source : AC5 50) chain B residue 191 type sequence L description binding site for residue DGP B 401 source : AC5 51) chain B residue 201 type sequence C description binding site for residue DGP B 401 source : AC5 52) chain B residue 202 type sequence T description binding site for residue DGP B 401 source : AC5 53) chain B residue 236 type sequence V description binding site for residue DGP B 401 source : AC5 54) chain B residue 13 type sequence G description binding site for residue ATP B 402 source : AC6 55) chain B residue 14 type sequence S description binding site for residue ATP B 402 source : AC6 56) chain B residue 15 type sequence T description binding site for residue ATP B 402 source : AC6 57) chain B residue 16 type sequence G description binding site for residue ATP B 402 source : AC6 58) chain B residue 17 type sequence K description binding site for residue ATP B 402 source : AC6 59) chain B residue 18 type sequence G description binding site for residue ATP B 402 source : AC6 60) chain B residue 41 type sequence A description binding site for residue ATP B 402 source : AC6 61) chain B residue 42 type sequence G description binding site for residue ATP B 402 source : AC6 62) chain B residue 43 type sequence H description binding site for residue ATP B 402 source : AC6 63) chain B residue 44 type sequence T description binding site for residue ATP B 402 source : AC6 64) chain B residue 187 type sequence Q description binding site for residue ATP B 402 source : AC6 65) chain B residue 294 type sequence N description binding site for residue ATP B 402 source : AC6 66) chain B residue 295 type sequence F description binding site for residue ATP B 402 source : AC6 67) chain B residue 297 type sequence N description binding site for residue ATP B 402 source : AC6 68) chain B residue 330 type sequence G description binding site for residue ATP B 402 source : AC6 69) chain B residue 331 type sequence P description binding site for residue ATP B 402 source : AC6 70) chain B residue 264 type BINDING sequence V description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6TNH source Swiss-Prot : SWS_FT_FI3 71) chain B residue 269 type BINDING sequence R description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6TNH source Swiss-Prot : SWS_FT_FI3 72) chain A residue 264 type BINDING sequence V description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6TNH source Swiss-Prot : SWS_FT_FI3 73) chain A residue 269 type BINDING sequence R description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6TNH source Swiss-Prot : SWS_FT_FI3 74) chain A residue 14 type ACT_SITE sequence S description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_04166, ECO:0000305|PubMed:33926954 source Swiss-Prot : SWS_FT_FI1 75) chain B residue 14 type ACT_SITE sequence S description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_04166, ECO:0000305|PubMed:33926954 source Swiss-Prot : SWS_FT_FI1 76) chain A residue 16 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 77) chain A residue 17 type BINDING sequence K description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 78) chain A residue 18 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 79) chain A residue 40 type BINDING sequence N description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 80) chain A residue 42 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 81) chain A residue 43 type BINDING sequence H description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 82) chain A residue 44 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 83) chain A residue 127 type BINDING sequence S description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 84) chain A residue 128 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 85) chain A residue 142 type BINDING sequence R description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 86) chain A residue 187 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 87) chain A residue 202 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 88) chain A residue 263 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 89) chain A residue 294 type BINDING sequence N description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 90) chain A residue 297 type BINDING sequence N description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 91) chain A residue 330 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 14 type BINDING sequence S description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 15 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 16 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 17 type BINDING sequence K description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 18 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 40 type BINDING sequence N description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 42 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 43 type BINDING sequence H description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 100) chain B residue 44 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 101) chain B residue 127 type BINDING sequence S description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 102) chain B residue 128 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 103) chain B residue 142 type BINDING sequence R description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 104) chain B residue 187 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 105) chain B residue 202 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 106) chain B residue 263 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 107) chain B residue 294 type BINDING sequence N description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 108) chain B residue 297 type BINDING sequence N description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 109) chain B residue 330 type BINDING sequence G description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 110) chain A residue 15 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2 111) chain A residue 14 type BINDING sequence S description BINDING => ECO:0000269|PubMed:33926955, ECO:0007744|PDB:6FM1 source Swiss-Prot : SWS_FT_FI2

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