eF-site ID 6fe3-B PDB Code 6fe3 Chain B click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1439 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence B:  VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPL DVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRN VPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLIT ALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHH CNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISN VTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRS KNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIK SNRAQWERVLET Description Functional site 1) chain B residue 665 type sequence N description binding site for residue GAI A 1002 source : AC2 2) chain B residue 810 type sequence H description binding site for residue GAI A 1012 source : AD3 3) chain B residue 691 type sequence Y description binding site for residue GOL B 1001 source : AD4 4) chain B residue 694 type sequence L description binding site for residue GOL B 1001 source : AD4 5) chain B residue 688 type sequence G description binding site for residue GOL B 1002 source : AD5 6) chain B residue 689 type sequence N description binding site for residue GOL B 1002 source : AD5 7) chain B residue 692 type sequence E description binding site for residue GOL B 1002 source : AD5 8) chain B residue 893 type sequence C description binding site for residue GOL B 1002 source : AD5 9) chain B residue 894 type sequence L description binding site for residue GOL B 1002 source : AD5 10) chain B residue 895 type sequence Q description binding site for residue GOL B 1002 source : AD5 11) chain B residue 896 type sequence G description binding site for residue GOL B 1002 source : AD5 12) chain B residue 686 type sequence Y description binding site for residue GOL B 1003 source : AD6 13) chain B residue 691 type sequence Y description binding site for residue GOL B 1003 source : AD6 14) chain B residue 673 type sequence H description binding site for residue ZN B 1004 source : AD7 15) chain B residue 709 type sequence H description binding site for residue ZN B 1004 source : AD7 16) chain B residue 710 type sequence D description binding site for residue ZN B 1004 source : AD7 17) chain B residue 822 type sequence D description binding site for residue ZN B 1004 source : AD7 18) chain B residue 710 type sequence D description binding site for residue MG B 1005 source : AD8 19) chain B residue 762 type sequence D description binding site for residue GAI B 1006 source : AD9 20) chain B residue 764 type sequence L description binding site for residue GAI B 1006 source : AD9 21) chain B residue 769 type sequence R description binding site for residue GAI B 1006 source : AD9 22) chain B residue 644 type sequence K description binding site for residue GOL B 1008 source : AE2 23) chain B residue 696 type sequence E description binding site for residue GOL B 1008 source : AE2

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