eF-site ID 6fe3-AB PDB Code 6fe3 Chain A, B click to enlarge Title Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1439 Classification HYDROLASE Compound Phosphodiesterase Source (Q8WQX9_9TRYP) Sequence A:  VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPL DVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRN VPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLIT ALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHH CNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISN VTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRS KNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIK SNRAQWERVLETR B:  VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPL DVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRN VPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLIT ALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHH CNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISN VTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRS KNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIK SNRAQWERVLET Description Functional site 1) chain A residue 753 type sequence L description binding site for residue GAI A 1001 source : AC1 2) chain A residue 754 type sequence S description binding site for residue GAI A 1001 source : AC1 3) chain A residue 759 type sequence D description binding site for residue GAI A 1001 source : AC1 4) chain A residue 762 type sequence D description binding site for residue GAI A 1001 source : AC1 5) chain A residue 769 type sequence R description binding site for residue GAI A 1001 source : AC1 6) chain A residue 915 type sequence L description binding site for residue GAI A 1001 source : AC1 7) chain A residue 913 type sequence R description binding site for residue GAI A 1002 source : AC2 8) chain B residue 665 type sequence N description binding site for residue GAI A 1002 source : AC2 9) chain A residue 785 type sequence M description binding site for residue D68 A 1003 source : AC3 10) chain A residue 822 type sequence D description binding site for residue D68 A 1003 source : AC3 11) chain A residue 825 type sequence N description binding site for residue D68 A 1003 source : AC3 12) chain A residue 826 type sequence V description binding site for residue D68 A 1003 source : AC3 13) chain A residue 836 type sequence W description binding site for residue D68 A 1003 source : AC3 14) chain A residue 837 type sequence A description binding site for residue D68 A 1003 source : AC3 15) chain A residue 840 type sequence V description binding site for residue D68 A 1003 source : AC3 16) chain A residue 844 type sequence F description binding site for residue D68 A 1003 source : AC3 17) chain A residue 861 type sequence M description binding site for residue D68 A 1003 source : AC3 18) chain A residue 873 type sequence G description binding site for residue D68 A 1003 source : AC3 19) chain A residue 874 type sequence Q description binding site for residue D68 A 1003 source : AC3 20) chain A residue 876 type sequence G description binding site for residue D68 A 1003 source : AC3 21) chain A residue 877 type sequence F description binding site for residue D68 A 1003 source : AC3 22) chain A residue 880 type sequence F description binding site for residue D68 A 1003 source : AC3 23) chain A residue 881 type sequence V description binding site for residue D68 A 1003 source : AC3 24) chain A residue 673 type sequence H description binding site for residue ZN A 1004 source : AC4 25) chain A residue 709 type sequence H description binding site for residue ZN A 1004 source : AC4 26) chain A residue 710 type sequence D description binding site for residue ZN A 1004 source : AC4 27) chain A residue 822 type sequence D description binding site for residue ZN A 1004 source : AC4 28) chain A residue 710 type sequence D description binding site for residue MG A 1005 source : AC5 29) chain A residue 646 type sequence G description binding site for residue FMT A 1006 source : AC6 30) chain A residue 648 type sequence S description binding site for residue FMT A 1006 source : AC6 31) chain A residue 651 type sequence V description binding site for residue FMT A 1006 source : AC6 32) chain A residue 646 type sequence G description binding site for residue FMT A 1007 source : AC7 33) chain A residue 762 type sequence D description binding site for residue FMT A 1007 source : AC7 34) chain A residue 763 type sequence G description binding site for residue FMT A 1007 source : AC7 35) chain A residue 689 type sequence N description binding site for residue FMT A 1008 source : AC8 36) chain A residue 896 type sequence G description binding site for residue FMT A 1008 source : AC8 37) chain A residue 811 type sequence R description binding site for residue GAI A 1010 source : AD1 38) chain A residue 815 type sequence E description binding site for residue GAI A 1010 source : AD1 39) chain A residue 644 type sequence K description binding site for residue GAI A 1011 source : AD2 40) chain A residue 768 type sequence E description binding site for residue GAI A 1011 source : AD2 41) chain A residue 692 type sequence E description binding site for residue GAI A 1012 source : AD3 42) chain B residue 810 type sequence H description binding site for residue GAI A 1012 source : AD3 43) chain A residue 691 type sequence Y description binding site for residue GOL B 1001 source : AD4 44) chain A residue 694 type sequence L description binding site for residue GOL B 1001 source : AD4 45) chain A residue 695 type sequence T description binding site for residue GOL B 1001 source : AD4 46) chain B residue 691 type sequence Y description binding site for residue GOL B 1001 source : AD4 47) chain B residue 694 type sequence L description binding site for residue GOL B 1001 source : AD4 48) chain B residue 688 type sequence G description binding site for residue GOL B 1002 source : AD5 49) chain B residue 689 type sequence N description binding site for residue GOL B 1002 source : AD5 50) chain B residue 692 type sequence E description binding site for residue GOL B 1002 source : AD5 51) chain B residue 893 type sequence C description binding site for residue GOL B 1002 source : AD5 52) chain B residue 894 type sequence L description binding site for residue GOL B 1002 source : AD5 53) chain B residue 895 type sequence Q description binding site for residue GOL B 1002 source : AD5 54) chain B residue 896 type sequence G description binding site for residue GOL B 1002 source : AD5 55) chain A residue 644 type sequence K description binding site for residue GOL B 1003 source : AD6 56) chain A residue 696 type sequence E description binding site for residue GOL B 1003 source : AD6 57) chain B residue 686 type sequence Y description binding site for residue GOL B 1003 source : AD6 58) chain B residue 691 type sequence Y description binding site for residue GOL B 1003 source : AD6 59) chain B residue 673 type sequence H description binding site for residue ZN B 1004 source : AD7 60) chain B residue 709 type sequence H description binding site for residue ZN B 1004 source : AD7 61) chain B residue 710 type sequence D description binding site for residue ZN B 1004 source : AD7 62) chain B residue 822 type sequence D description binding site for residue ZN B 1004 source : AD7 63) chain B residue 710 type sequence D description binding site for residue MG B 1005 source : AD8 64) chain B residue 762 type sequence D description binding site for residue GAI B 1006 source : AD9 65) chain B residue 764 type sequence L description binding site for residue GAI B 1006 source : AD9 66) chain B residue 769 type sequence R description binding site for residue GAI B 1006 source : AD9 67) chain A residue 686 type sequence Y description binding site for residue GOL B 1008 source : AE2 68) chain A residue 691 type sequence Y description binding site for residue GOL B 1008 source : AE2 69) chain B residue 644 type sequence K description binding site for residue GOL B 1008 source : AE2 70) chain B residue 696 type sequence E description binding site for residue GOL B 1008 source : AE2 71) chain A residue 709-720 type prosite sequence HDLDHMGLNNSF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF source prosite : PS00126

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