eF-site ID 6fb6-ABDEFG PDB Code 6fb6 Chain A, B, D, E, F, G click to enlarge Title Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with an altered version of its target DNA (Haemoglobin beta subunit gene) at 5NNN region in the presence of Manganese Classification DNA BINDING PROTEIN Compound I-CreI monomer A Source (6FB6) Sequence A:  NTKYNKEFLLYLAGFVDSDGSIIAQIKPNQSVKFKHRLQL TFDVTQKTQRRWFLDKLVDEIGVGYVADSGSVSKYRLSEI KPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDK FLEVCTWVDQIAALNDSKTRKTTSETVRAVLDS B:  NTKYNKEFLLYLAGFVDGDGSIIAQIKPNQSGKFKHKLSL TFKVTQKTQRRWFLDKLVDEIGVGYVYDSGSVSNYYLSEI KPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDK FLEVCTWVDQVAALNDSKTRKTTSETVRAVLDSL D:  TCAGACTTGTCCAC E:  GGGAGTCAGA F:  TCTGACTCCTGTGG G:  ACAAGTCTGA Description Functional site 1) chain A residue 20 type sequence D description binding site for residue MN A 201 source : AC1 2) chain B residue 19 type sequence G description binding site for residue MN A 201 source : AC1 3) chain D residue 514 type sequence C description binding site for residue MN A 201 source : AC1 4) chain G residue 615 type sequence A description binding site for residue MN A 201 source : AC1 5) chain A residue 20 type sequence D description binding site for residue MN A 202 source : AC2 6) chain B residue 19 type sequence G description binding site for residue MN A 202 source : AC2 7) chain B residue 20 type sequence D description binding site for residue MN A 202 source : AC2 8) chain D residue 514 type sequence C description binding site for residue MN A 202 source : AC2 9) chain E residue 515 type sequence G description binding site for residue MN A 202 source : AC2 10) chain F residue 614 type sequence G description binding site for residue MN A 202 source : AC2 11) chain G residue 615 type sequence A description binding site for residue MN A 202 source : AC2 12) chain A residue 19 type sequence S description binding site for residue MN A 203 source : AC3 13) chain B residue 20 type sequence D description binding site for residue MN A 203 source : AC3 14) chain E residue 515 type sequence G description binding site for residue MN A 203 source : AC3 15) chain F residue 614 type sequence G description binding site for residue MN A 203 source : AC3 16) chain B residue 19 type catalytic sequence G description 233 source MCSA : MCSA1 17) chain B residue 20 type catalytic sequence D description 233 source MCSA : MCSA1 18) chain B residue 20 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 19) chain B residue 19 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1

Display surface Download Links