eF-site ID 6fb2-ABDEFG PDB Code 6fb2 Chain A, B, D, E, F, G click to enlarge Title Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Manganese Classification DNA BINDING PROTEIN Compound DNA endonuclease I-CreI Source (6FB2) Sequence A:  NTKYNKEFLLYLAGFVDSDGSIIAQIKPNQSVKFKHRLQL TFDVTQKTQRRWFLDKLVDEIGVGYVADSGSVSKYRLSEI KPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDK FLEVCTWVDQIAALNDSKTRKTTSETVRAVLDS B:  NTKYNKEFLLYLAGFVDGDGSIIAQIKPNQSGKFKHKLSL TFKVTQKTQRRWFLDKLVDEIGVGYVYDSGSVSNYYLSEI KPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDK FLEVCTWVDQVAALNDSKTRKTTSETVRAVLDSL D:  TCAGACTTCTCCAC E:  AGGAGTCAGA F:  TCTGACTCCTGTGG G:  AGAAGTCTGA Description Functional site 1) chain A residue 20 type sequence D description binding site for residue MN A 201 source : AC1 2) chain B residue 20 type sequence D description binding site for residue MN A 201 source : AC1 3) chain D residue 514 type sequence C description binding site for residue MN A 201 source : AC1 4) chain E residue 515 type sequence A description binding site for residue MN A 201 source : AC1 5) chain F residue 614 type sequence G description binding site for residue MN A 201 source : AC1 6) chain G residue 615 type sequence A description binding site for residue MN A 201 source : AC1 7) chain A residue 19 type sequence S description binding site for residue MN A 202 source : AC2 8) chain B residue 20 type sequence D description binding site for residue MN A 202 source : AC2 9) chain E residue 515 type sequence A description binding site for residue MN A 202 source : AC2 10) chain F residue 614 type sequence G description binding site for residue MN A 202 source : AC2 11) chain A residue 20 type sequence D description binding site for residue MN A 203 source : AC3 12) chain B residue 19 type sequence G description binding site for residue MN A 203 source : AC3 13) chain D residue 514 type sequence C description binding site for residue MN A 203 source : AC3 14) chain G residue 615 type sequence A description binding site for residue MN A 203 source : AC3 15) chain B residue 19 type catalytic sequence G description 233 source MCSA : MCSA1 16) chain B residue 20 type catalytic sequence D description 233 source MCSA : MCSA1 17) chain B residue 20 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 18) chain B residue 19 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1

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