eF-site ID 6fb1-AB PDB Code 6fb1 Chain A, B click to enlarge Title Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Magnesium Classification DNA BINDING PROTEIN Compound DNA endonuclease I-CreI Source (6FB1) Sequence A:  NTKYNKEFLLYLAGFVDSDGSIIAQIKPNQSVKFKHRLQL TFDVTQKTQRRWFLDKLVDEIGVGYVADSGSVSKYRLSEI KPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDK FLEVCTWVDQIAALNDSKTRKTTSETVRAVLDS B:  NTKYNKEFLLYLAGFVDGDGSIIAQIKPNQSGKFKHKLSL TFKVTQKTQRRWFLDKLVDEIGVGYVYDSGSVSNYYLSEI KPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDK FLEVCTWVDQVAALNDSKTRKTTSETVRAVLDSL Description Functional site 1) chain A residue 18 type sequence D description binding site for residue MG A 201 source : AC1 2) chain A residue 19 type sequence S description binding site for residue MG A 201 source : AC1 3) chain B residue 20 type sequence D description binding site for residue MG A 201 source : AC1 4) chain B residue 47 type sequence Q description binding site for residue MG A 201 source : AC1 5) chain A residue 20 type sequence D description binding site for residue MG A 202 source : AC2 6) chain B residue 20 type sequence D description binding site for residue MG A 202 source : AC2 7) chain A residue 20 type sequence D description binding site for residue MG A 203 source : AC3 8) chain A residue 51 type sequence R description binding site for residue MG A 203 source : AC3 9) chain B residue 18 type sequence D description binding site for residue MG A 203 source : AC3 10) chain B residue 19 type sequence G description binding site for residue MG A 203 source : AC3 11) chain B residue 19 type catalytic sequence G description 233 source MCSA : MCSA1 12) chain B residue 20 type catalytic sequence D description 233 source MCSA : MCSA1 13) chain B residue 19 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 14) chain B residue 20 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1

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