eF-site ID 6f8v-AB PDB Code 6f8v Chain A, B click to enlarge Title Crystal structure of the PDE4D catalytic domain in complex with GEBR-18b Classification HYDROLASE Compound cAMP-specific 3',5'-cyclic phosphodiesterase 4D Source Homo sapiens (Human) (PDE4D_HUMAN) Sequence A:  KTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIH AADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDH PGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLK TMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRE WYQSTIP B:  DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQER DLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVV QSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSN QFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIF QNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVET KKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLY RQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQ VGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQST IPQA Description Functional site 1) chain A residue 330 type sequence H description binding site for residue ZN A 601 source : AC1 2) chain A residue 366 type sequence H description binding site for residue ZN A 601 source : AC1 3) chain A residue 367 type sequence D description binding site for residue ZN A 601 source : AC1 4) chain A residue 484 type sequence D description binding site for residue ZN A 601 source : AC1 5) chain A residue 367 type sequence D description binding site for residue MG A 602 source : AC2 6) chain A residue 264 type sequence D description binding site for residue MG A 603 source : AC3 7) chain A residue 467 type sequence D description binding site for residue MG A 604 source : AC4 8) chain A residue 471 type sequence D description binding site for residue MG A 604 source : AC4 9) chain A residue 527 type sequence H description binding site for residue MG A 604 source : AC4 10) chain A residue 325 type sequence Y description binding site for residue D0B A 605 source : AC5 11) chain A residue 437 type sequence T description binding site for residue D0B A 605 source : AC5 12) chain A residue 439 type sequence M description binding site for residue D0B A 605 source : AC5 13) chain A residue 484 type sequence D description binding site for residue D0B A 605 source : AC5 14) chain A residue 485 type sequence L description binding site for residue D0B A 605 source : AC5 15) chain A residue 487 type sequence N description binding site for residue D0B A 605 source : AC5 16) chain A residue 502 type sequence I description binding site for residue D0B A 605 source : AC5 17) chain A residue 506 type sequence F description binding site for residue D0B A 605 source : AC5 18) chain A residue 523 type sequence M description binding site for residue D0B A 605 source : AC5 19) chain A residue 535 type sequence Q description binding site for residue D0B A 605 source : AC5 20) chain A residue 538 type sequence F description binding site for residue D0B A 605 source : AC5 21) chain B residue 330 type sequence H description binding site for residue ZN B 601 source : AC6 22) chain B residue 366 type sequence H description binding site for residue ZN B 601 source : AC6 23) chain B residue 367 type sequence D description binding site for residue ZN B 601 source : AC6 24) chain B residue 484 type sequence D description binding site for residue ZN B 601 source : AC6 25) chain B residue 367 type sequence D description binding site for residue MG B 602 source : AC7 26) chain B residue 437 type sequence T description binding site for residue D0B B 603 source : AC8 27) chain B residue 439 type sequence M description binding site for residue D0B B 603 source : AC8 28) chain B residue 484 type sequence D description binding site for residue D0B B 603 source : AC8 29) chain B residue 485 type sequence L description binding site for residue D0B B 603 source : AC8 30) chain B residue 487 type sequence N description binding site for residue D0B B 603 source : AC8 31) chain B residue 499 type sequence T description binding site for residue D0B B 603 source : AC8 32) chain B residue 502 type sequence I description binding site for residue D0B B 603 source : AC8 33) chain B residue 506 type sequence F description binding site for residue D0B B 603 source : AC8 34) chain B residue 523 type sequence M description binding site for residue D0B B 603 source : AC8 35) chain B residue 535 type sequence Q description binding site for residue D0B B 603 source : AC8 36) chain B residue 538 type sequence F description binding site for residue D0B B 603 source : AC8 37) chain A residue 462 type BINDING sequence G description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 462 type BINDING sequence G description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 502 type BINDING sequence I description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 502 type BINDING sequence I description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 41) chain A residue 462 type ACT_SITE sequence G description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 462 type ACT_SITE sequence G description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 366-377 type prosite sequence HDVDHPGVSNQF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF source prosite : PS00126 44) chain A residue 387 type CROSSLNK sequence L description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) source Swiss-Prot : SWS_FT_FI8 45) chain B residue 387 type CROSSLNK sequence L description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) source Swiss-Prot : SWS_FT_FI8 46) chain A residue 299 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI6 47) chain A residue 301 type MOD_RES sequence F description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI6 48) chain B residue 299 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI6 49) chain B residue 301 type MOD_RES sequence F description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI6 50) chain A residue 348 type MOD_RES sequence E description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI7 51) chain A residue 375 type MOD_RES sequence N description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI7 52) chain B residue 348 type MOD_RES sequence E description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI7 53) chain B residue 375 type MOD_RES sequence N description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI7 54) chain A residue 503 type BINDING sequence M description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 55) chain B residue 503 type BINDING sequence M description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 56) chain A residue 466 type BINDING sequence L description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 57) chain B residue 466 type BINDING sequence L description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links