eF-site ID 6f26-A PDB Code 6f26 Chain A click to enlarge Title Crystal structure of human Casein Kinase I delta in complex with compound 31b Classification TRANSFERASE Compound Casein kinase I isoform delta Source (KC1D_HUMAN) Sequence A:  LRVGNRYRLGRKIGDIYLGTDIAAGEEVAIKLECVLHIES KIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLF NFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDN FLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNL TGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLN FCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML Description Functional site 1) chain A residue 127 type sequence R description binding site for residue SO4 A 301 source : AC1 2) chain A residue 154 type sequence K description binding site for residue SO4 A 301 source : AC1 3) chain A residue 171 type sequence K description binding site for residue SO4 A 301 source : AC1 4) chain A residue 178 type sequence R description binding site for residue SO4 A 302 source : AC2 5) chain A residue 214 type sequence Q description binding site for residue SO4 A 302 source : AC2 6) chain A residue 215 type sequence G description binding site for residue SO4 A 302 source : AC2 7) chain A residue 224 type sequence K description binding site for residue SO4 A 302 source : AC2 8) chain A residue 267 type sequence S description binding site for residue SO4 A 303 source : AC3 9) chain A residue 270 type sequence R description binding site for residue SO4 A 303 source : AC3 10) chain A residue 274 type sequence R description binding site for residue SO4 A 303 source : AC3 11) chain A residue 250 type sequence T description binding site for residue SO4 A 304 source : AC4 12) chain A residue 253 type sequence N description binding site for residue SO4 A 304 source : AC4 13) chain A residue 157 type sequence R description binding site for residue SO4 A 305 source : AC5 14) chain A residue 164 type sequence H description binding site for residue SO4 A 305 source : AC5 15) chain A residue 192 type sequence R description binding site for residue SO4 A 305 source : AC5 16) chain A residue 263 type sequence K description binding site for residue SO4 A 305 source : AC5 17) chain A residue 157 type sequence R description binding site for residue SO4 A 306 source : AC6 18) chain A residue 162 type sequence H description binding site for residue SO4 A 306 source : AC6 19) chain A residue 263 type sequence K description binding site for residue SO4 A 306 source : AC6 20) chain A residue 103 type sequence K description binding site for residue SO4 A 307 source : AC7 21) chain A residue 282 type sequence F description binding site for residue SO4 A 307 source : AC7 22) chain A residue 283 type sequence S description binding site for residue SO4 A 307 source : AC7 23) chain A residue 268 type sequence Y description binding site for residue SO4 A 308 source : AC8 24) chain A residue 265 type sequence D description binding site for residue SO4 A 309 source : AC9 25) chain A residue 268 type sequence Y description binding site for residue SO4 A 309 source : AC9 26) chain A residue 92 type sequence L description binding site for residue SO4 A 310 source : AD1 27) chain A residue 290 type sequence W description binding site for residue SO4 A 310 source : AD1 28) chain A residue 245 type sequence P description binding site for residue SO4 A 311 source : AD2 29) chain A residue 246 type sequence S description binding site for residue SO4 A 311 source : AD2 30) chain A residue 279 type sequence R description binding site for residue SO4 A 311 source : AD2 31) chain A residue 176 type sequence T description binding site for residue SO4 A 312 source : AD3 32) chain A residue 177 type sequence A description binding site for residue SO4 A 312 source : AD3 33) chain A residue 225 type sequence Y description binding site for residue SO4 A 312 source : AD3 34) chain A residue 193 type sequence R description binding site for residue SO4 A 313 source : AD4 35) chain A residue 259 type sequence R description binding site for residue SO4 A 313 source : AD4 36) chain A residue 260 type sequence F description binding site for residue SO4 A 313 source : AD4 37) chain A residue 15 type sequence I description binding site for residue C9Z A 314 source : AD5 38) chain A residue 23 type sequence I description binding site for residue C9Z A 314 source : AD5 39) chain A residue 36 type sequence A description binding site for residue C9Z A 314 source : AD5 40) chain A residue 80 type sequence M description binding site for residue C9Z A 314 source : AD5 41) chain A residue 82 type sequence M description binding site for residue C9Z A 314 source : AD5 42) chain A residue 85 type sequence L description binding site for residue C9Z A 314 source : AD5 43) chain A residue 91 type sequence D description binding site for residue C9Z A 314 source : AD5 44) chain A residue 128 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 15-38 type prosite sequence IGDIYLGTDIAAGEEVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK source prosite : PS00107 46) chain A residue 124-136 type prosite sequence FIHRDVKPDNFLM description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM source prosite : PS00108 47) chain A residue 15 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 38 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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