eF-site ID 6f1w-B PDB Code 6f1w Chain B click to enlarge Title Crystal structure of human Casein Kinase I delta in complex with compound 31a Classification TRANSFERASE Compound Casein kinase I isoform delta Source (KC1D_HUMAN) Sequence B:  MELRVGNRYRLGRKIGDIYLGTDIAAGEEVAIKLECVLHI ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLED LFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKP DNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENK NLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSL PWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWN Description (1)  Casein kinase I isoform delta (E.C.2.7.11.1,2.7.11.26) Functional site 1) chain B residue 13 type sequence R description binding site for residue CG5 A 308 source : AC8 2) chain B residue 87 type sequence P description binding site for residue CG5 A 308 source : AC8 3) chain B residue 178 type sequence R description binding site for residue SO4 B 301 source : AC9 4) chain B residue 214 type sequence Q description binding site for residue SO4 B 301 source : AC9 5) chain B residue 215 type sequence G description binding site for residue SO4 B 301 source : AC9 6) chain B residue 224 type sequence K description binding site for residue SO4 B 301 source : AC9 7) chain B residue 127 type sequence R description binding site for residue SO4 B 302 source : AD1 8) chain B residue 154 type sequence K description binding site for residue SO4 B 302 source : AD1 9) chain B residue 171 type sequence K description binding site for residue SO4 B 302 source : AD1 10) chain B residue 121 type sequence S description binding site for residue SO4 B 303 source : AD2 11) chain B residue 157 type sequence R description binding site for residue SO4 B 303 source : AD2 12) chain B residue 263 type sequence K description binding site for residue SO4 B 303 source : AD2 13) chain B residue 157 type sequence R description binding site for residue SO4 B 304 source : AD3 14) chain B residue 164 type sequence H description binding site for residue SO4 B 304 source : AD3 15) chain B residue 192 type sequence R description binding site for residue SO4 B 304 source : AD3 16) chain B residue 263 type sequence K description binding site for residue SO4 B 304 source : AD3 17) chain B residue 267 type sequence S description binding site for residue SO4 B 305 source : AD4 18) chain B residue 270 type sequence R description binding site for residue SO4 B 305 source : AD4 19) chain B residue 271 type sequence Q description binding site for residue SO4 B 305 source : AD4 20) chain B residue 274 type sequence R description binding site for residue SO4 B 305 source : AD4 21) chain B residue 271 type sequence Q description binding site for residue SO4 B 306 source : AD5 22) chain B residue 278 type sequence H description binding site for residue SO4 B 306 source : AD5 23) chain B residue 110 type sequence D description binding site for residue SO4 B 307 source : AD6 24) chain B residue 274 type sequence R description binding site for residue SO4 B 307 source : AD6 25) chain B residue 286 type sequence Y description binding site for residue SO4 B 307 source : AD6 26) chain B residue 103 type sequence K description binding site for residue SO4 B 308 source : AD7 27) chain B residue 281 type sequence G description binding site for residue SO4 B 308 source : AD7 28) chain B residue 282 type sequence F description binding site for residue SO4 B 308 source : AD7 29) chain B residue 283 type sequence S description binding site for residue SO4 B 308 source : AD7 30) chain B residue 15 type sequence I description binding site for residue CG5 B 309 source : AD8 31) chain B residue 23 type sequence I description binding site for residue CG5 B 309 source : AD8 32) chain B residue 36 type sequence A description binding site for residue CG5 B 309 source : AD8 33) chain B residue 80 type sequence M description binding site for residue CG5 B 309 source : AD8 34) chain B residue 82 type sequence M description binding site for residue CG5 B 309 source : AD8 35) chain B residue 85 type sequence L description binding site for residue CG5 B 309 source : AD8 36) chain B residue 15 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 38 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 128 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 15-38 type prosite sequence IGDIYLGTDIAAGEEVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK source prosite : PS00107 40) chain B residue 124-136 type prosite sequence FIHRDVKPDNFLM description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM source prosite : PS00108

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