eF-site ID 6f1w-AB PDB Code 6f1w Chain A, B click to enlarge Title Crystal structure of human Casein Kinase I delta in complex with compound 31a Classification TRANSFERASE Compound Casein kinase I isoform delta Source (KC1D_HUMAN) Sequence A:  LRVGNRYRLGRKIGSGGDIYLGTDIAAGEEVAIKLECVKP QLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGP SLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHR DVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPY RENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFN LGSLPWQGLKAAXKRQKYERISEKKMSTPIEVLCKGYPSE FATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYV FDWNM B:  MELRVGNRYRLGRKIGDIYLGTDIAAGEEVAIKLECVLHI ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLED LFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKP DNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENK NLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSL PWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWN Description (1)  Casein kinase I isoform delta (E.C.2.7.11.1,2.7.11.26) Functional site 1) chain A residue 127 type sequence R description binding site for residue SO4 A 301 source : AC1 2) chain A residue 154 type sequence K description binding site for residue SO4 A 301 source : AC1 3) chain A residue 171 type sequence K description binding site for residue SO4 A 301 source : AC1 4) chain A residue 178 type sequence R description binding site for residue SO4 A 302 source : AC2 5) chain A residue 214 type sequence Q description binding site for residue SO4 A 302 source : AC2 6) chain A residue 215 type sequence G description binding site for residue SO4 A 302 source : AC2 7) chain A residue 224 type sequence K description binding site for residue SO4 A 302 source : AC2 8) chain A residue 157 type sequence R description binding site for residue SO4 A 303 source : AC3 9) chain A residue 164 type sequence H description binding site for residue SO4 A 303 source : AC3 10) chain A residue 192 type sequence R description binding site for residue SO4 A 303 source : AC3 11) chain A residue 263 type sequence K description binding site for residue SO4 A 303 source : AC3 12) chain A residue 168 type sequence R description binding site for residue SO4 A 304 source : AC4 13) chain A residue 267 type sequence S description binding site for residue SO4 A 305 source : AC5 14) chain A residue 270 type sequence R description binding site for residue SO4 A 305 source : AC5 15) chain A residue 271 type sequence Q description binding site for residue SO4 A 305 source : AC5 16) chain A residue 274 type sequence R description binding site for residue SO4 A 305 source : AC5 17) chain A residue 193 type sequence R description binding site for residue SO4 A 306 source : AC6 18) chain A residue 259 type sequence R description binding site for residue SO4 A 306 source : AC6 19) chain A residue 260 type sequence F description binding site for residue SO4 A 306 source : AC6 20) chain A residue 157 type sequence R description binding site for residue SO4 A 307 source : AC7 21) chain A residue 162 type sequence H description binding site for residue SO4 A 307 source : AC7 22) chain A residue 263 type sequence K description binding site for residue SO4 A 307 source : AC7 23) chain A residue 15 type sequence I description binding site for residue CG5 A 308 source : AC8 24) chain A residue 23 type sequence I description binding site for residue CG5 A 308 source : AC8 25) chain A residue 36 type sequence A description binding site for residue CG5 A 308 source : AC8 26) chain A residue 80 type sequence M description binding site for residue CG5 A 308 source : AC8 27) chain A residue 82 type sequence M description binding site for residue CG5 A 308 source : AC8 28) chain A residue 85 type sequence L description binding site for residue CG5 A 308 source : AC8 29) chain A residue 91 type sequence D description binding site for residue CG5 A 308 source : AC8 30) chain B residue 13 type sequence R description binding site for residue CG5 A 308 source : AC8 31) chain B residue 87 type sequence P description binding site for residue CG5 A 308 source : AC8 32) chain B residue 178 type sequence R description binding site for residue SO4 B 301 source : AC9 33) chain B residue 214 type sequence Q description binding site for residue SO4 B 301 source : AC9 34) chain B residue 215 type sequence G description binding site for residue SO4 B 301 source : AC9 35) chain B residue 224 type sequence K description binding site for residue SO4 B 301 source : AC9 36) chain B residue 127 type sequence R description binding site for residue SO4 B 302 source : AD1 37) chain B residue 154 type sequence K description binding site for residue SO4 B 302 source : AD1 38) chain B residue 171 type sequence K description binding site for residue SO4 B 302 source : AD1 39) chain B residue 121 type sequence S description binding site for residue SO4 B 303 source : AD2 40) chain B residue 157 type sequence R description binding site for residue SO4 B 303 source : AD2 41) chain B residue 263 type sequence K description binding site for residue SO4 B 303 source : AD2 42) chain B residue 157 type sequence R description binding site for residue SO4 B 304 source : AD3 43) chain B residue 164 type sequence H description binding site for residue SO4 B 304 source : AD3 44) chain B residue 192 type sequence R description binding site for residue SO4 B 304 source : AD3 45) chain B residue 263 type sequence K description binding site for residue SO4 B 304 source : AD3 46) chain B residue 267 type sequence S description binding site for residue SO4 B 305 source : AD4 47) chain B residue 270 type sequence R description binding site for residue SO4 B 305 source : AD4 48) chain B residue 271 type sequence Q description binding site for residue SO4 B 305 source : AD4 49) chain B residue 274 type sequence R description binding site for residue SO4 B 305 source : AD4 50) chain B residue 271 type sequence Q description binding site for residue SO4 B 306 source : AD5 51) chain B residue 278 type sequence H description binding site for residue SO4 B 306 source : AD5 52) chain B residue 110 type sequence D description binding site for residue SO4 B 307 source : AD6 53) chain B residue 274 type sequence R description binding site for residue SO4 B 307 source : AD6 54) chain B residue 286 type sequence Y description binding site for residue SO4 B 307 source : AD6 55) chain B residue 103 type sequence K description binding site for residue SO4 B 308 source : AD7 56) chain B residue 281 type sequence G description binding site for residue SO4 B 308 source : AD7 57) chain B residue 282 type sequence F description binding site for residue SO4 B 308 source : AD7 58) chain B residue 283 type sequence S description binding site for residue SO4 B 308 source : AD7 59) chain A residue 13 type sequence R description binding site for residue CG5 B 309 source : AD8 60) chain A residue 87 type sequence P description binding site for residue CG5 B 309 source : AD8 61) chain B residue 15 type sequence I description binding site for residue CG5 B 309 source : AD8 62) chain B residue 23 type sequence I description binding site for residue CG5 B 309 source : AD8 63) chain B residue 36 type sequence A description binding site for residue CG5 B 309 source : AD8 64) chain B residue 80 type sequence M description binding site for residue CG5 B 309 source : AD8 65) chain B residue 82 type sequence M description binding site for residue CG5 B 309 source : AD8 66) chain B residue 85 type sequence L description binding site for residue CG5 B 309 source : AD8 67) chain A residue 15-38 type prosite sequence IGSGGDIYLGTDIAAGEEVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK source prosite : PS00107 68) chain B residue 15-38 type prosite sequence IGDIYLGTDIAAGEEVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK source prosite : PS00107 69) chain A residue 124-136 type prosite sequence FIHRDVKPDNFLM description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM source prosite : PS00108 70) chain B residue 124-136 type prosite sequence FIHRDVKPDNFLM description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM source prosite : PS00108 71) chain B residue 128 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 72) chain B residue 38 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 73) chain B residue 15 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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