eF-site ID 6f09-Q
PDB Code 6f09
Chain Q

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Title Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
Classification SIGNALING PROTEIN
Compound 14-3-3 protein zeta/delta
Source Homo sapiens (Human) (UBP8_HUMAN)
Sequence Q:  DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEER
NLLSVAYKNVVGARRSSWRVVSSIEQKTEAEKQQMAREYR
EKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKG
DYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPT
HPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAEL
DTLSEESYKDSTLIMQLLRDNLTLWT
Description


Functional site

1) chain Q
residue 3
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

2) chain Q
residue 68
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

3) chain Q
residue 58
type MOD_RES
sequence S
description Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269|PubMed:11956222, ECO:0000269|PubMed:12865427, ECO:0000269|PubMed:15883165, ECO:0000269|PubMed:16376338
source Swiss-Prot : SWS_FT_FI4

4) chain Q
residue 184
type MOD_RES
sequence S
description Phosphoserine; by MAPK8 => ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15696159
source Swiss-Prot : SWS_FT_FI5

5) chain Q
residue 207
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
source Swiss-Prot : SWS_FT_FI6

6) chain Q
residue 210
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P63102
source Swiss-Prot : SWS_FT_FI7


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