eF-site ID 6f09-ABCDPQRS
PDB Code 6f09
Chain A, B, C, D, P, Q, R, S

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Title Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
Classification SIGNALING PROTEIN
Compound 14-3-3 protein zeta/delta
Source Homo sapiens (Human) (UBP8_HUMAN)
Sequence A:  SYXSPDI
B:  RSYXSPDIT
C:  RSYXSP
D:  RSYXSPDITQ
P:  DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEER
NLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMARE
YREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKM
KGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQ
PTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIA
ELDTLSEESYKDSTLIMQLLRDNLTLWTS
Q:  DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEER
NLLSVAYKNVVGARRSSWRVVSSIEQKTEAEKQQMAREYR
EKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKG
DYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPT
HPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAEL
DTLSEESYKDSTLIMQLLRDNLTLWT
R:  DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEER
NLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMARE
YREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKM
KGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQ
PTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIA
LDSEESYKDSTLIMQLLRDNLTLWTS
S:  DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEER
NLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMARE
YREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKM
KGDYYRYLAEVAAGDKKGIVDQSQQAYQEAFEISKKEMQP
THPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAE
LDTLSEESYKDSTLIMQLLRDNLTLWTS
Description


Functional site

1) chain A
residue 719
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18669648
source Swiss-Prot : SWS_FT_FI2

2) chain B
residue 719
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18669648
source Swiss-Prot : SWS_FT_FI2

3) chain C
residue 719
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18669648
source Swiss-Prot : SWS_FT_FI2

4) chain D
residue 719
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18669648
source Swiss-Prot : SWS_FT_FI2

5) chain P
residue 3
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

6) chain P
residue 68
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

7) chain Q
residue 3
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

8) chain Q
residue 68
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

9) chain R
residue 3
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

10) chain R
residue 68
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

11) chain S
residue 3
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

12) chain S
residue 68
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

13) chain P
residue 58
type MOD_RES
sequence S
description Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269|PubMed:11956222, ECO:0000269|PubMed:12865427, ECO:0000269|PubMed:15883165, ECO:0000269|PubMed:16376338
source Swiss-Prot : SWS_FT_FI4

14) chain Q
residue 58
type MOD_RES
sequence S
description Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269|PubMed:11956222, ECO:0000269|PubMed:12865427, ECO:0000269|PubMed:15883165, ECO:0000269|PubMed:16376338
source Swiss-Prot : SWS_FT_FI4

15) chain R
residue 58
type MOD_RES
sequence S
description Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269|PubMed:11956222, ECO:0000269|PubMed:12865427, ECO:0000269|PubMed:15883165, ECO:0000269|PubMed:16376338
source Swiss-Prot : SWS_FT_FI4

16) chain S
residue 58
type MOD_RES
sequence S
description Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269|PubMed:11956222, ECO:0000269|PubMed:12865427, ECO:0000269|PubMed:15883165, ECO:0000269|PubMed:16376338
source Swiss-Prot : SWS_FT_FI4

17) chain P
residue 184
type MOD_RES
sequence S
description Phosphoserine; by MAPK8 => ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15696159
source Swiss-Prot : SWS_FT_FI5

18) chain Q
residue 184
type MOD_RES
sequence S
description Phosphoserine; by MAPK8 => ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15696159
source Swiss-Prot : SWS_FT_FI5

19) chain R
residue 184
type MOD_RES
sequence S
description Phosphoserine; by MAPK8 => ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15696159
source Swiss-Prot : SWS_FT_FI5

20) chain S
residue 184
type MOD_RES
sequence S
description Phosphoserine; by MAPK8 => ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15696159
source Swiss-Prot : SWS_FT_FI5

21) chain P
residue 207
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
source Swiss-Prot : SWS_FT_FI6

22) chain Q
residue 207
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
source Swiss-Prot : SWS_FT_FI6

23) chain R
residue 207
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
source Swiss-Prot : SWS_FT_FI6

24) chain S
residue 207
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
source Swiss-Prot : SWS_FT_FI6

25) chain A
residue 718
type MOD_RES
sequence X
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

26) chain B
residue 718
type MOD_RES
sequence X
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

27) chain C
residue 718
type MOD_RES
sequence X
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

28) chain D
residue 718
type MOD_RES
sequence X
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

29) chain R
residue 56
type MOD_RES
sequence R
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

30) chain R
residue 127
type MOD_RES
sequence R
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

31) chain S
residue 56
type MOD_RES
sequence R
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

32) chain S
residue 127
type MOD_RES
sequence R
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

33) chain P
residue 41-51
type prosite
sequence RNLLSVAYKNV
description 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
source prosite : PS00796

34) chain P
residue 211-230
type prosite
sequence YKDSTLIMQLLRDNLTLWTS
description 1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
source prosite : PS00797

35) chain P
residue 210
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P63102
source Swiss-Prot : SWS_FT_FI7

36) chain Q
residue 210
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P63102
source Swiss-Prot : SWS_FT_FI7

37) chain R
residue 210
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P63102
source Swiss-Prot : SWS_FT_FI7

38) chain S
residue 210
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P63102
source Swiss-Prot : SWS_FT_FI7


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