eF-site/Summary 6f08-A

eF-site ID	6f08-A
PDB Code	6f08
Chain	A

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Title	14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1)
Classification	PEPTIDE BINDING PROTEIN
Compound	14-3-3 protein zeta/delta
Source	Homo sapiens (Human) (SOS1_HUMAN)

Sequence	A:	MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEE RNLLSVAYKNVVGARRSSWRVVSSIEQKKKQQMAREYREK IETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDY YRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHP IRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDT LSEESYKDSTLIMQLLRDNLTLWTS

Description

Functional site


1)	chain	A
	residue	1
	type
	sequence	M
	description	binding site for residue 1PE A 301
	source	: AC1

2)	chain	A
	residue	9
	type
	sequence	K
	description	binding site for residue 1PE A 301
	source	: AC1

3)	chain	A
	residue	21
	type
	sequence	D
	description	binding site for residue 1PE A 301
	source	: AC1

4)	chain	A
	residue	25
	type
	sequence	C
	description	binding site for residue 1PE A 301
	source	: AC1

5)	chain	A
	residue	1
	type	MOD_RES
	sequence	M
	description	N-acetylmethionine => ECO:0000269\|Ref.8, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712
	source	Swiss-Prot : SWS_FT_FI2

6)	chain	A
	residue	3
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI3

7)	chain	A
	residue	68
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI3

8)	chain	A
	residue	58
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269\|PubMed:11956222, ECO:0000269\|PubMed:12865427, ECO:0000269\|PubMed:15883165, ECO:0000269\|PubMed:16376338
	source	Swiss-Prot : SWS_FT_FI4

9)	chain	A
	residue	184
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by MAPK8 => ECO:0000269\|PubMed:15071501, ECO:0000269\|PubMed:15696159
	source	Swiss-Prot : SWS_FT_FI5

10)	chain	A
	residue	207
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231
	source	Swiss-Prot : SWS_FT_FI6

11)	chain	A
	residue	210
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000250\|UniProtKB:P63102
	source	Swiss-Prot : SWS_FT_FI7

12)	chain	A
	residue	41-51
	type	prosite
	sequence	RNLLSVAYKNV
	description	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
	source	prosite : PS00796

13)	chain	A
	residue	211-230
	type	prosite
	sequence	YKDSTLIMQLLRDNLTLWTS
	description	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
	source	prosite : PS00797