eF-site ID 6f06-AB PDB Code 6f06 Chain A, B click to enlarge Title CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(azetidin-3-yl)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide Classification HYDROLASE Compound Cathepsin L1 Source Homo sapiens (Human) (CATL1_HUMAN) Sequence A:  APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFR KTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDN GGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEK ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSED MDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVK MAKDRRNHCGIASAASYPTV B:  APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFR KTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDN GGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEK ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSED MDHGVLVVGYGFESDNNKYWLVKNSWGEEWGMGGYVKMAK DRRNHCGIASAASYPTV Description (1)  Cathepsin L1 (E.C.3.4.22.15) Functional site 1) chain A residue 23 type sequence G description binding site for residue C7T A 301 source : AC1 2) chain A residue 24 type sequence S description binding site for residue C7T A 301 source : AC1 3) chain A residue 25 type sequence C description binding site for residue C7T A 301 source : AC1 4) chain A residue 26 type sequence W description binding site for residue C7T A 301 source : AC1 5) chain A residue 63 type sequence E description binding site for residue C7T A 301 source : AC1 6) chain A residue 66 type sequence N description binding site for residue C7T A 301 source : AC1 7) chain A residue 67 type sequence G description binding site for residue C7T A 301 source : AC1 8) chain A residue 68 type sequence G description binding site for residue C7T A 301 source : AC1 9) chain A residue 69 type sequence L description binding site for residue C7T A 301 source : AC1 10) chain A residue 70 type sequence M description binding site for residue C7T A 301 source : AC1 11) chain A residue 135 type sequence A description binding site for residue C7T A 301 source : AC1 12) chain A residue 161 type sequence M description binding site for residue C7T A 301 source : AC1 13) chain A residue 162 type sequence D description binding site for residue C7T A 301 source : AC1 14) chain A residue 214 type sequence A description binding site for residue C7T A 301 source : AC1 15) chain A residue 25 type sequence C description binding site for residue ZN A 302 source : AC2 16) chain A residue 163 type sequence H description binding site for residue ZN A 302 source : AC2 17) chain A residue 137 type sequence D description binding site for residue ZN A 303 source : AC3 18) chain A residue 140 type sequence H description binding site for residue ZN A 303 source : AC3 19) chain A residue 48 type sequence L description binding site for residue ZN A 304 source : AC4 20) chain A residue 50 type sequence E description binding site for residue ZN A 304 source : AC4 21) chain A residue 86 type sequence E description binding site for residue ZN A 304 source : AC4 22) chain A residue 92 type sequence E description binding site for residue ZN A 305 source : AC5 23) chain A residue 96 type sequence E description binding site for residue ZN A 305 source : AC5 24) chain B residue 191 type sequence E description binding site for residue ZN A 305 source : AC5 25) chain A residue 71 type sequence D description binding site for residue ZN A 306 source : AC6 26) chain A residue 114 type sequence D description binding site for residue ZN A 306 source : AC6 27) chain A residue 140 type sequence H description binding site for residue ZN A 307 source : AC7 28) chain A residue 153 type sequence E description binding site for residue ZN A 307 source : AC7 29) chain A residue 155 type sequence D description binding site for residue ZN A 307 source : AC7 30) chain A residue 19 type sequence Q description binding site for residue CL A 308 source : AC8 31) chain A residue 163 type sequence H description binding site for residue CL A 308 source : AC8 32) chain B residue 23 type sequence G description binding site for residue C7T B 301 source : AC9 33) chain B residue 24 type sequence S description binding site for residue C7T B 301 source : AC9 34) chain B residue 25 type sequence C description binding site for residue C7T B 301 source : AC9 35) chain B residue 26 type sequence W description binding site for residue C7T B 301 source : AC9 36) chain B residue 61 type sequence G description binding site for residue C7T B 301 source : AC9 37) chain B residue 63 type sequence E description binding site for residue C7T B 301 source : AC9 38) chain B residue 66 type sequence N description binding site for residue C7T B 301 source : AC9 39) chain B residue 67 type sequence G description binding site for residue C7T B 301 source : AC9 40) chain B residue 68 type sequence G description binding site for residue C7T B 301 source : AC9 41) chain B residue 69 type sequence L description binding site for residue C7T B 301 source : AC9 42) chain B residue 70 type sequence M description binding site for residue C7T B 301 source : AC9 43) chain B residue 135 type sequence A description binding site for residue C7T B 301 source : AC9 44) chain B residue 162 type sequence D description binding site for residue C7T B 301 source : AC9 45) chain B residue 214 type sequence A description binding site for residue C7T B 301 source : AC9 46) chain B residue 25 type sequence C description binding site for residue ZN B 302 source : AD1 47) chain B residue 163 type sequence H description binding site for residue ZN B 302 source : AD1 48) chain B residue 137 type sequence D description binding site for residue ZN B 303 source : AD2 49) chain B residue 140 type sequence H description binding site for residue ZN B 303 source : AD2 50) chain A residue 87 type sequence E description binding site for residue ZN B 304 source : AD3 51) chain B residue 6 type sequence D description binding site for residue ZN B 304 source : AD3 52) chain B residue 9 type sequence E description binding site for residue ZN B 304 source : AD3 53) chain B residue 48 type sequence L description binding site for residue ZN B 305 source : AD4 54) chain B residue 50 type sequence E description binding site for residue ZN B 305 source : AD4 55) chain B residue 86 type sequence E description binding site for residue ZN B 305 source : AD4 56) chain B residue 71 type sequence D description binding site for residue ZN B 306 source : AD5 57) chain B residue 114 type sequence D description binding site for residue ZN B 306 source : AD5 58) chain B residue 140 type sequence H description binding site for residue ZN B 307 source : AD6 59) chain B residue 153 type sequence E description binding site for residue ZN B 307 source : AD6 60) chain B residue 155 type sequence D description binding site for residue ZN B 307 source : AD6 61) chain A residue 191 type sequence E description binding site for residue ZN B 308 source : AD7 62) chain B residue 92 type sequence E description binding site for residue ZN B 308 source : AD7 63) chain B residue 96 type sequence E description binding site for residue ZN B 308 source : AD7 64) chain A residue 191 type sequence E description binding site for residue ZN B 309 source : AD8 65) chain B residue 10 type sequence K description binding site for residue ZN B 309 source : AD8 66) chain B residue 92 type sequence E description binding site for residue ZN B 309 source : AD8 67) chain B residue 96 type sequence E description binding site for residue ZN B 309 source : AD8 68) chain B residue 19 type sequence Q description binding site for residue CL B 310 source : AD9 69) chain B residue 163 type sequence H description binding site for residue CL B 310 source : AD9 70) chain B residue 189 type sequence W description binding site for residue CL B 310 source : AD9 71) chain A residue 108 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 72) chain B residue 108 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 73) chain A residue 25 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:9468501 source Swiss-Prot : SWS_FT_FI1 74) chain B residue 25 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:9468501 source Swiss-Prot : SWS_FT_FI1 75) chain A residue 163 type ACT_SITE sequence H description source Swiss-Prot : SWS_FT_FI2 76) chain A residue 187 type ACT_SITE sequence N description source Swiss-Prot : SWS_FT_FI2 77) chain B residue 163 type ACT_SITE sequence H description source Swiss-Prot : SWS_FT_FI2 78) chain B residue 187 type ACT_SITE sequence N description source Swiss-Prot : SWS_FT_FI2 79) chain A residue 19-30 type prosite sequence QGQCGSCWAFSA description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA source prosite : PS00139 80) chain A residue 161-171 type prosite sequence MDHGVLVVGYG description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG source prosite : PS00639 81) chain A residue 182-201 type prosite sequence YWLVKNSWGEEWGMGGYVKM description THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM source prosite : PS00640

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