eF-site ID 6ewk-A
PDB Code 6ewk
Chain A

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Title T. californica AChE in complex with a 3-hydroxy-2-pyridine aldoxime.
Classification HYDROLASE
Compound Acetylcholinesterase
Source ORGANISM_COMMON: Pacific electric ray; ORGANISM_SCIENTIFIC: Tetronarce californica;
Sequence A:  SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNM
RFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEM
WNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSG
SSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQE
APGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGG
ASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRR
RAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLP
FDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGV
NKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHA
NDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICP
LMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYE
IEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPN
EPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVF
WNQFLPKLLNAT
Description (1)  Acetylcholinesterase (E.C.3.1.1.7)


Functional site

1) chain A
residue 200
type ACT_SITE
sequence S
description Acyl-ester intermediate
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 327
type ACT_SITE
sequence E
description Charge relay system
source Swiss-Prot : SWS_FT_FI2

3) chain A
residue 440
type ACT_SITE
sequence H
description Charge relay system
source Swiss-Prot : SWS_FT_FI2

4) chain A
residue 59
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558
source Swiss-Prot : SWS_FT_FI3

5) chain A
residue 187-202
type prosite
sequence FGGDPKTVTIFGESAG
description CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpktVtIfGeSAG
source prosite : PS00122

6) chain A
residue 92-102
type prosite
sequence EDCLYLNIWVP
description CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIWvP
source prosite : PS00941

7) chain A
residue 416
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558, ECO:0000269|PubMed:1678899
source Swiss-Prot : SWS_FT_FI4

8) chain A
residue 457
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299
source Swiss-Prot : SWS_FT_FI5

9) chain A
residue 533
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299
source Swiss-Prot : SWS_FT_FI5


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