eF-site ID 6ewb-ABCDEFGHIJKL PDB Code 6ewb Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Crystal structure of GII.4 UNSW 2012 P domain in complex with Fab 10E9 Classification VIRAL PROTEIN Compound VP1 Source (6EWB) Sequence A:  SKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQN GRCTTDGVLLGTTQLSPVNICTFRGDVTHITGSRNYTMNL ASQNWNDYDPTEEIPAPLGTPDFVGKIQGVLTQTTRTDGS TRGHKATVYTGSADFAPKLGRVQFETDTDRDFEANQNTKF TPVGVIQDGGTTHRNEPQQWVLPSYSGRNTHNVHLAPAVA PTFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQYFYQ EAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTG QHDLVIPPNGYFRFDSWVNQFYTLAPM B:  KPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNG RCTTDGVLLGTTQLSPVNICTFRGDVTHITGSRNYTMNLA SQNWNDYDPTEEIPAPLGTPDFVGKIQGVLTQTTRTDGST RGHKATVYTGSADFAPKLGRVQFETDTDRDFEANQNTKFT PVGVIQDGGTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAP TFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQYFYQE AAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQ HDLVIPPNGYFRFDSWVNQFYTLAPM C:  GPGSKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQ PQNGRCTTDGVLLGTTQLSPVNICTFRGDVTHITGSRNYT MNLASQNWNDYDPTEEIPAPLGTPDFVGKIQGVLTQTTRT DGSTRGHKATVYTGSADFAPKLGRVQFETDTDRDFEANQN TKFTPVGVIQDGGTTHRNEPQQWVLPSYSGRNTHNVHLAP AVAPTFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQY FYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVA HTGQHDLVIPPNGYFRFDSWVNQFYTLAPM D:  PGSKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQP QNGRCTTDGVLLGTTQLSPVNICTFRGDVTHITGSRNYTM NLASQNWNDYDPTEEIPAPLGTPDFVGKIQGVLTQTTRTD GSTRGHKATVYTGSADFAPKLGRVQFETDTDRDFEANQNT KFTPVGVIQDGGTTHRNEPQQWVLPSYSGRNTHNVHLAPA VAPTFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQYF YQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAH TGQHDLVIPPNGYFRFDSWVNQFYTLAPM E:  QVQLQQSGAELMKPGASVKISCTATGYTFITYWIQWVKQR PGHGLEWIGETLPGSGSTNYNEKFKGKATFTADTSSNTAY MQLSSLTSEDSAIYYCARIGRSNDYWGQGTTLTVSSAKTT PPSVYPLAPMVTLGCLVKGYFPEPVTVTWSLSSGVHTFPA VLQSDLYTLSSSVTVTVTCNVAHPASSTKVDKKIV F:  QIVLTQSPTIMSASPGEKVTMTCSASSSVDYMHWYQQKSG TSPKRWIYDTYKLASGVPARFSGSGSGTSYSLTINSMEAE DAATYYCQQWSSNPLTFGAGTKLELKRADAAPTVSIFPPS SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLN SWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTS TSPIVKSFN G:  QVQLQQSGAELMKPGASVKISCTATGYTFITYWIQWVKQR PGHGLEWIGETLPGSGSTNYNEKFKGKATFTADTSSNTAY MQLSSLTSEDSAIYYCARIGRSNDYWGQGTTLTVSSAKTT PPSVYPLAPGNSMVTLGCLVKGYFPEPVTVTWNSGSLSSG VHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPAS STKVDKKIVPR H:  QVQLQQSGAELMKPGASVKISCTATGYTFITYWIQWVKQR PGHGLEWIGETLPGSGSTNYNEKFKGKATFTADTSSNTAY MQLSSLTSEDSAIYYCARIGRSNDYWGQGTTLTVSSAKTT PPSVYPLAPGSMVTLGCLVKGYFPEPVTVTWNSGSLSSGV HTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASS TKVDKKIVPR I:  GQIVLTQSPTIMSASPGEKVTMTCSASSSVDYMHWYQQKS GTSPKRWIYDTYKLASGVPARFSGSGSGTSYSLTINSMEA EDAATYYCQQWSSNPLTFGAGTKLELKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNR J:  QVQLQQSGAELMKPGASVKISCTATGYTFITYWIQWVKQR PGHGLEWIGETLPGSGSTNYNEKFKGKATFTADTSSNTAY MQLSSLTSEDSAIYYCARIGRSNDYWGQGTTLTVSSAKTT PPSVYPLAPSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVH TFPAVLQSDLYTLSSSVTVPSTWPSETVTCNVAHPASSTK VDKKIVP K:  GQIVLTQSPTIMSASPGEKVTMTCSASSSVDYMHWYQQKS GTSPKRWIYDTYKLASGVPARFSGSGSGTSYSLTINSMEA EDAATYYCQQWSSNPLTFGAGTKLELKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGNGVLNSWT DQDSKDSTYSMSSTLTLTKYERHNSYTCEATHKTSTSPIV KSFNR L:  QIVLTQSPTIMSASPGEKVTMTCSASSSVDYMHWYQQKSG TSPKRWIYDTYKLASGVPARFSGSGSGTSYSLTINSMEAE DAATYYCQQWSSNPLTFGAGTKLELKRADAAPTVSIFPPS SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLN SWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTS TSPIVKSFNR Description Functional site 1) chain B residue 486 type sequence L description binding site for residue EDO B 601 source : AC1 2) chain B residue 505 type sequence H description binding site for residue EDO B 601 source : AC1 3) chain B residue 508 type sequence V description binding site for residue EDO B 601 source : AC1 4) chain L residue 36 type sequence Q description binding site for residue EDO L 301 source : AC2 5) chain L residue 37 type sequence Q description binding site for residue EDO L 301 source : AC2 6) chain L residue 38 type sequence K description binding site for residue EDO L 301 source : AC2 7) chain L residue 41 type sequence T description binding site for residue EDO L 301 source : AC2 8) chain L residue 42 type sequence S description binding site for residue EDO L 301 source : AC2 9) chain L residue 44 type sequence K description binding site for residue EDO L 301 source : AC2 10) chain F residue 191-197 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290

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