eF-site ID 6etw-A PDB Code 6etw Chain A click to enlarge Title Crystal structure of KDM4D with tetrazolhydrazide compound 3 Classification OXIDOREDUCTASE Compound Lysine-specific demethylase 4D Source (KDM4D_HUMAN) Sequence A:  AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAK IIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYH KKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRI YNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGV VIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPK TWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALIS PTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCA EAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQP ERYDLWKRGQ Description Functional site 1) chain A residue 238 type sequence C description binding site for residue ZN A 401 source : AC1 2) chain A residue 244 type sequence H description binding site for residue ZN A 401 source : AC1 3) chain A residue 310 type sequence C description binding site for residue ZN A 401 source : AC1 4) chain A residue 312 type sequence C description binding site for residue ZN A 401 source : AC1 5) chain A residue 128 type sequence N description binding site for residue CL A 402 source : AC2 6) chain A residue 186 type sequence K description binding site for residue CL A 402 source : AC2 7) chain A residue 123 type sequence R description binding site for residue EDO A 403 source : AC3 8) chain A residue 124 type sequence K description binding site for residue EDO A 403 source : AC3 9) chain A residue 127 type sequence K description binding site for residue EDO A 403 source : AC3 10) chain A residue 128 type sequence N description binding site for residue EDO A 403 source : AC3 11) chain A residue 150 type sequence K description binding site for residue EDO A 404 source : AC4 12) chain A residue 151 type sequence Q description binding site for residue EDO A 404 source : AC4 13) chain A residue 152 type sequence W description binding site for residue EDO A 404 source : AC4 14) chain A residue 153 type sequence N description binding site for residue EDO A 404 source : AC4 15) chain A residue 156 type sequence H description binding site for residue EDO A 404 source : AC4 16) chain A residue 251 type sequence P description binding site for residue EDO A 405 source : AC5 17) chain A residue 252 type sequence T description binding site for residue EDO A 405 source : AC5 18) chain A residue 255 type sequence K description binding site for residue EDO A 405 source : AC5 19) chain A residue 263 type sequence R description binding site for residue EDO A 405 source : AC5 20) chain A residue 27 type sequence E description binding site for residue EDO A 406 source : AC6 21) chain A residue 37 type sequence Y description binding site for residue EDO A 406 source : AC6 22) chain A residue 60 type sequence R description binding site for residue SO4 A 407 source : AC7 23) chain A residue 61 type sequence E description binding site for residue SO4 A 407 source : AC7 24) chain A residue 62 type sequence T description binding site for residue SO4 A 407 source : AC7 25) chain A residue 65 type sequence N description binding site for residue SO4 A 407 source : AC7 26) chain A residue 19 type sequence M description binding site for residue SO4 A 408 source : AC8 27) chain A residue 20 type sequence I description binding site for residue SO4 A 408 source : AC8 28) chain A residue 255 type sequence K description binding site for residue SO4 A 408 source : AC8 29) chain A residue 192 type sequence H description binding site for residue NI A 409 source : AC9 30) chain A residue 194 type sequence E description binding site for residue NI A 409 source : AC9 31) chain A residue 280 type sequence H description binding site for residue NI A 409 source : AC9 32) chain A residue 181 type sequence Y description binding site for residue BX5 A 410 source : AD1 33) chain A residue 189 type sequence F description binding site for residue BX5 A 410 source : AD1 34) chain A residue 192 type sequence H description binding site for residue BX5 A 410 source : AD1 35) chain A residue 194 type sequence E description binding site for residue BX5 A 410 source : AD1 36) chain A residue 200 type sequence S description binding site for residue BX5 A 410 source : AD1 37) chain A residue 202 type sequence N description binding site for residue BX5 A 410 source : AD1 38) chain A residue 210 type sequence K description binding site for residue BX5 A 410 source : AD1 39) chain A residue 280 type sequence H description binding site for residue BX5 A 410 source : AD1 40) chain A residue 102 type sequence R description binding site for residue GOL A 411 source : AD2 41) chain A residue 103 type sequence H description binding site for residue GOL A 411 source : AD2 42) chain A residue 106 type sequence N description binding site for residue GOL A 411 source : AD2 43) chain A residue 192 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 194 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 280 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 244 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 47) chain A residue 310 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 48) chain A residue 312 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 49) chain A residue 238 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 50) chain A residue 26 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4 51) chain A residue 27 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4 52) chain A residue 245 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 136 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 54) chain A residue 202 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 55) chain A residue 210 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1

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