eF-site ID 6ete-A PDB Code 6ete Chain A click to enlarge Title Crystal structure of KDM4D with tetrazolhydrazide compound 5 Classification OXIDOREDUCTASE Compound Lysine-specific demethylase 4D Source (KDM4D_HUMAN) Sequence A:  AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAK IIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYH KKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRI YNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGV VIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPK TWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALIS PTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCA EAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQP ERYDLWKRGQ Description (1)  Lysine-specific demethylase 4D (E.C.1.14.11.-) Functional site 1) chain A residue 238 type sequence C description binding site for residue ZN A 401 source : AC1 2) chain A residue 244 type sequence H description binding site for residue ZN A 401 source : AC1 3) chain A residue 310 type sequence C description binding site for residue ZN A 401 source : AC1 4) chain A residue 312 type sequence C description binding site for residue ZN A 401 source : AC1 5) chain A residue 192 type sequence H description binding site for residue NI A 402 source : AC2 6) chain A residue 194 type sequence E description binding site for residue NI A 402 source : AC2 7) chain A residue 280 type sequence H description binding site for residue NI A 402 source : AC2 8) chain A residue 156 type sequence H description binding site for residue NI A 403 source : AC3 9) chain A residue 123 type sequence R description binding site for residue EDO A 404 source : AC4 10) chain A residue 124 type sequence K description binding site for residue EDO A 404 source : AC4 11) chain A residue 127 type sequence K description binding site for residue EDO A 404 source : AC4 12) chain A residue 128 type sequence N description binding site for residue EDO A 404 source : AC4 13) chain A residue 150 type sequence K description binding site for residue EDO A 405 source : AC5 14) chain A residue 151 type sequence Q description binding site for residue EDO A 405 source : AC5 15) chain A residue 152 type sequence W description binding site for residue EDO A 405 source : AC5 16) chain A residue 153 type sequence N description binding site for residue EDO A 405 source : AC5 17) chain A residue 156 type sequence H description binding site for residue EDO A 405 source : AC5 18) chain A residue 157 type sequence L description binding site for residue EDO A 405 source : AC5 19) chain A residue 255 type sequence K description binding site for residue EDO A 406 source : AC6 20) chain A residue 263 type sequence R description binding site for residue EDO A 406 source : AC6 21) chain A residue 118 type sequence F description binding site for residue EDO A 407 source : AC7 22) chain A residue 263 type sequence R description binding site for residue EDO A 407 source : AC7 23) chain A residue 264 type sequence I description binding site for residue EDO A 407 source : AC7 24) chain A residue 265 type sequence T description binding site for residue EDO A 407 source : AC7 25) chain A residue 109 type sequence K description binding site for residue EDO A 408 source : AC8 26) chain A residue 111 type sequence Q description binding site for residue EDO A 408 source : AC8 27) chain A residue 132 type sequence N description binding site for residue EDO A 408 source : AC8 28) chain A residue 185 type sequence W description binding site for residue EDO A 408 source : AC8 29) chain A residue 186 type sequence K description binding site for residue EDO A 408 source : AC8 30) chain A residue 103 type sequence H description binding site for residue EDO A 409 source : AC9 31) chain A residue 106 type sequence N description binding site for residue EDO A 409 source : AC9 32) chain A residue 179 type sequence Y description binding site for residue EDO A 410 source : AD1 33) chain A residue 181 type sequence Y description binding site for residue EDO A 410 source : AD1 34) chain A residue 194 type sequence E description binding site for residue EDO A 410 source : AD1 35) chain A residue 200 type sequence S description binding site for residue EDO A 410 source : AD1 36) chain A residue 292 type sequence A description binding site for residue EDO A 410 source : AD1 37) chain A residue 294 type sequence N description binding site for residue EDO A 410 source : AD1 38) chain A residue 113 type sequence P description binding site for residue SO4 A 411 source : AD2 39) chain A residue 124 type sequence K description binding site for residue SO4 A 411 source : AD2 40) chain A residue 128 type sequence N description binding site for residue SO4 A 411 source : AD2 41) chain A residue 185 type sequence W description binding site for residue SO4 A 411 source : AD2 42) chain A residue 186 type sequence K description binding site for residue SO4 A 411 source : AD2 43) chain A residue 60 type sequence R description binding site for residue SO4 A 412 source : AD3 44) chain A residue 61 type sequence E description binding site for residue SO4 A 412 source : AD3 45) chain A residue 62 type sequence T description binding site for residue SO4 A 412 source : AD3 46) chain A residue 181 type sequence Y description binding site for residue BWK A 413 source : AD4 47) chain A residue 192 type sequence H description binding site for residue BWK A 413 source : AD4 48) chain A residue 194 type sequence E description binding site for residue BWK A 413 source : AD4 49) chain A residue 200 type sequence S description binding site for residue BWK A 413 source : AD4 50) chain A residue 202 type sequence N description binding site for residue BWK A 413 source : AD4 51) chain A residue 210 type sequence K description binding site for residue BWK A 413 source : AD4 52) chain A residue 212 type sequence W description binding site for residue BWK A 413 source : AD4 53) chain A residue 280 type sequence H description binding site for residue BWK A 413 source : AD4 54) chain A residue 292 type sequence A description binding site for residue BWK A 413 source : AD4 55) chain A residue 136 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 56) chain A residue 202 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 210 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 245 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 192 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 194 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 280 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 62) chain A residue 238 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 63) chain A residue 244 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 64) chain A residue 310 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 65) chain A residue 312 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 66) chain A residue 26 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4 67) chain A residue 27 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4

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