eF-site ID 6ehg-ABC PDB Code 6ehg Chain A, B, C click to enlarge Title complement component C3b in complex with a nanobody Classification IMMUNE SYSTEM Compound Complement C3 Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  SPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDF PGKKLVLSSEKTVLTPATNHMGNVTFTIPANRKGRNKFVT VQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLY RIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLG VLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEY VLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEG TAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVL LDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIP IVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRV PVAVQGEETVQSLTQGDGVAKLSINTHPSQKPLSITVRTK KQEISEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRP GETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQV REPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVV ADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEG DHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGC TPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQP B:  EDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMN IFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFID LRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAF CSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEV KAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERL GREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTE DAVDAERLKHLIVTPSGCGEENMIGMTPTVIAVHYLDETE QWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKR APSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQ KPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQ EAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIA GYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEA TSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQAT FMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIH WESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKA KDQLTCNKFDLKVTIKPAPNKNTMILEICTRYRGDQDATM SILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVY AYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFI QKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKK HYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDE ENQKQCQDLGAFTESMVVFGCPN C:  QVQLVETGGGLVQAGGSLRLSCAASGSIFSLNAMGWFRQA PGKEREFVATINRSGGRTYYADSVKGRFTISRDNGKNMVY LQMHSLKPEDTAIYYCAAGTGWSPQTDNEYNYWGQGTQVT VSSH Description Functional site 1) chain B residue 954 type SITE sequence R description Cleavage; by factor I => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 1303 type SITE sequence R description Cleavage; by factor I source Swiss-Prot : SWS_FT_FI2 3) chain B residue 1320 type SITE sequence R description Cleavage; by factor I source Swiss-Prot : SWS_FT_FI2 4) chain A residue 297 type SITE sequence S description Cleavage; by factor I source Swiss-Prot : SWS_FT_FI2 5) chain A residue 303 type SITE sequence S description Cleavage; by factor I source Swiss-Prot : SWS_FT_FI2 6) chain B residue 1663 type SITE sequence N description Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604 source Swiss-Prot : SWS_FT_FI3 7) chain B residue 968 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI4 8) chain B residue 1321 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI4 9) chain B residue 1573 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI4 10) chain B residue 939 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150 source Swiss-Prot : SWS_FT_FI5 11) chain B residue 1617 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 source Swiss-Prot : SWS_FT_FI6 12) chain B residue 1010 type CROSSLNK sequence C description Isoglutamyl cysteine thioester (Cys-Gln) source Swiss-Prot : SWS_FT_FI7 13) chain B residue 1013 type CROSSLNK sequence E description Isoglutamyl cysteine thioester (Cys-Gln) source Swiss-Prot : SWS_FT_FI7 14) chain B residue 1007-1015 type prosite sequence PSGCGEENM description ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM source prosite : PS00477

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