eF-site ID 6egd-AD PDB Code 6egd Chain A, D click to enlarge Title Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Interleukin-1 receptor-associated kinase 4 Source (IRAK4_HUMAN) Sequence A:  FHSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVN NTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGF SSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQG AANGINFLHENHHIHRNIKSANILLDEAFTAKISDFGLAR ATAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEH REPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMY SVASQCLHEKKNKRPDIKKVQQLLQEMT D:  GSRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVY KGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLV ELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWH MRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAK ISDFGLARATAYMAPEALRGEITPKSDIYSFGVVLLEIIT GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD STSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT Description Functional site 1) chain D residue 192 type sequence M description binding site for residue J87 D 501 source : AC1 2) chain D residue 211 type sequence A description binding site for residue J87 D 501 source : AC1 3) chain D residue 213 type sequence K description binding site for residue J87 D 501 source : AC1 4) chain D residue 262 type sequence Y description binding site for residue J87 D 501 source : AC1 5) chain D residue 263 type sequence V description binding site for residue J87 D 501 source : AC1 6) chain D residue 264 type sequence Y description binding site for residue J87 D 501 source : AC1 7) chain D residue 265 type sequence M description binding site for residue J87 D 501 source : AC1 8) chain D residue 268 type sequence G description binding site for residue J87 D 501 source : AC1 9) chain D residue 272 type sequence D description binding site for residue J87 D 501 source : AC1 10) chain D residue 318 type sequence L description binding site for residue J87 D 501 source : AC1 11) chain D residue 328 type sequence S description binding site for residue J87 D 501 source : AC1 12) chain A residue 192 type sequence M description binding site for residue J87 A 501 source : AC2 13) chain A residue 211 type sequence A description binding site for residue J87 A 501 source : AC2 14) chain A residue 213 type sequence K description binding site for residue J87 A 501 source : AC2 15) chain A residue 262 type sequence Y description binding site for residue J87 A 501 source : AC2 16) chain A residue 263 type sequence V description binding site for residue J87 A 501 source : AC2 17) chain A residue 264 type sequence Y description binding site for residue J87 A 501 source : AC2 18) chain A residue 265 type sequence M description binding site for residue J87 A 501 source : AC2 19) chain A residue 266 type sequence P description binding site for residue J87 A 501 source : AC2 20) chain A residue 268 type sequence G description binding site for residue J87 A 501 source : AC2 21) chain A residue 318 type sequence L description binding site for residue J87 A 501 source : AC2 22) chain A residue 328 type sequence S description binding site for residue J87 A 501 source : AC2 23) chain A residue 329 type sequence D description binding site for residue J87 A 501 source : AC2 24) chain D residue 311 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 311 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 192 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 192 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 28) chain D residue 329 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 29) chain A residue 213 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 30) chain A residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 31) chain A residue 329 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 32) chain D residue 213 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 33) chain D residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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