eF-site ID 6egd-A PDB Code 6egd Chain A click to enlarge Title Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Interleukin-1 receptor-associated kinase 4 Source (IRAK4_HUMAN) Sequence A:  FHSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVN NTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGF SSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQG AANGINFLHENHHIHRNIKSANILLDEAFTAKISDFGLAR ATAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEH REPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMY SVASQCLHEKKNKRPDIKKVQQLLQEMT Description Functional site 1) chain A residue 192 type sequence M description binding site for residue J87 A 501 source : AC2 2) chain A residue 211 type sequence A description binding site for residue J87 A 501 source : AC2 3) chain A residue 213 type sequence K description binding site for residue J87 A 501 source : AC2 4) chain A residue 262 type sequence Y description binding site for residue J87 A 501 source : AC2 5) chain A residue 263 type sequence V description binding site for residue J87 A 501 source : AC2 6) chain A residue 264 type sequence Y description binding site for residue J87 A 501 source : AC2 7) chain A residue 265 type sequence M description binding site for residue J87 A 501 source : AC2 8) chain A residue 266 type sequence P description binding site for residue J87 A 501 source : AC2 9) chain A residue 268 type sequence G description binding site for residue J87 A 501 source : AC2 10) chain A residue 318 type sequence L description binding site for residue J87 A 501 source : AC2 11) chain A residue 328 type sequence S description binding site for residue J87 A 501 source : AC2 12) chain A residue 329 type sequence D description binding site for residue J87 A 501 source : AC2 13) chain A residue 311 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 192 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 213 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 16) chain A residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 17) chain A residue 329 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3

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