eF-site ID 6ega-AB PDB Code 6ega Chain A, B click to enlarge Title IRAK4 in complex with a type II inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Interleukin-1 receptor-associated kinase 4 Source (IRAK4_HUMAN) Sequence A:  HSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVNN TTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSS DDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGA ANGINFLHENHHIHRDIKSANILLDEAFTAKISDFVGTTA YMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREP QLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVA SQCLHEKKNKRPDIKKVQQLLQEMTA B:  RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKG YVNNTTVAVKKLAALKQQFDQEIKVMAKCQHENLVELLGF SSDGDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIA QGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFVG TTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEH REPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMY SVASQCLHEKKNKRPDIKKVQQLLQEMTA Description Functional site 1) chain A residue 192 type sequence M description binding site for residue J8A A 501 source : AC1 2) chain A residue 211 type sequence A description binding site for residue J8A A 501 source : AC1 3) chain A residue 213 type sequence K description binding site for residue J8A A 501 source : AC1 4) chain A residue 233 type sequence E description binding site for residue J8A A 501 source : AC1 5) chain A residue 236 type sequence V description binding site for residue J8A A 501 source : AC1 6) chain A residue 246 type sequence V description binding site for residue J8A A 501 source : AC1 7) chain A residue 262 type sequence Y description binding site for residue J8A A 501 source : AC1 8) chain A residue 263 type sequence V description binding site for residue J8A A 501 source : AC1 9) chain A residue 264 type sequence Y description binding site for residue J8A A 501 source : AC1 10) chain A residue 265 type sequence M description binding site for residue J8A A 501 source : AC1 11) chain A residue 268 type sequence G description binding site for residue J8A A 501 source : AC1 12) chain A residue 302 type sequence L description binding site for residue J8A A 501 source : AC1 13) chain A residue 308 type sequence I description binding site for residue J8A A 501 source : AC1 14) chain A residue 309 type sequence H description binding site for residue J8A A 501 source : AC1 15) chain A residue 318 type sequence L description binding site for residue J8A A 501 source : AC1 16) chain A residue 327 type sequence I description binding site for residue J8A A 501 source : AC1 17) chain A residue 328 type sequence S description binding site for residue J8A A 501 source : AC1 18) chain A residue 329 type sequence D description binding site for residue J8A A 501 source : AC1 19) chain A residue 330 type sequence F description binding site for residue J8A A 501 source : AC1 20) chain A residue 365 type sequence T description binding site for residue SO4 A 502 source : AC2 21) chain A residue 367 type sequence K description binding site for residue SO4 A 502 source : AC2 22) chain A residue 441 type sequence K description binding site for residue SO4 A 502 source : AC2 23) chain A residue 286 type sequence H description binding site for residue CO A 503 source : AC3 24) chain A residue 390 type sequence H description binding site for residue CO A 504 source : AC4 25) chain B residue 408 type sequence K description binding site for residue CO A 504 source : AC4 26) chain A residue 408 type sequence K description binding site for residue CO A 505 source : AC5 27) chain B residue 390 type sequence H description binding site for residue CO A 505 source : AC5 28) chain A residue 306 type sequence H description binding site for residue CO A 506 source : AC6 29) chain B residue 306 type sequence H description binding site for residue CO A 506 source : AC6 30) chain B residue 211 type sequence A description binding site for residue J8A B 501 source : AC7 31) chain B residue 213 type sequence K description binding site for residue J8A B 501 source : AC7 32) chain B residue 233 type sequence E description binding site for residue J8A B 501 source : AC7 33) chain B residue 237 type sequence M description binding site for residue J8A B 501 source : AC7 34) chain B residue 246 type sequence V description binding site for residue J8A B 501 source : AC7 35) chain B residue 262 type sequence Y description binding site for residue J8A B 501 source : AC7 36) chain B residue 263 type sequence V description binding site for residue J8A B 501 source : AC7 37) chain B residue 264 type sequence Y description binding site for residue J8A B 501 source : AC7 38) chain B residue 265 type sequence M description binding site for residue J8A B 501 source : AC7 39) chain B residue 268 type sequence G description binding site for residue J8A B 501 source : AC7 40) chain B residue 308 type sequence I description binding site for residue J8A B 501 source : AC7 41) chain B residue 309 type sequence H description binding site for residue J8A B 501 source : AC7 42) chain B residue 318 type sequence L description binding site for residue J8A B 501 source : AC7 43) chain B residue 327 type sequence I description binding site for residue J8A B 501 source : AC7 44) chain B residue 328 type sequence S description binding site for residue J8A B 501 source : AC7 45) chain B residue 329 type sequence D description binding site for residue J8A B 501 source : AC7 46) chain B residue 330 type sequence F description binding site for residue J8A B 501 source : AC7 47) chain B residue 365 type sequence T description binding site for residue SO4 B 502 source : AC8 48) chain B residue 367 type sequence K description binding site for residue SO4 B 502 source : AC8 49) chain B residue 441 type sequence K description binding site for residue SO4 B 502 source : AC8 50) chain B residue 286 type sequence H description binding site for residue CO B 503 source : AC9 51) chain B residue 286 type sequence H description binding site for residue CO B 503 source : AC9 52) chain B residue 166 type sequence H description binding site for residue CO B 504 source : AD1 53) chain B residue 166 type sequence H description binding site for residue CO B 504 source : AD1 54) chain B residue 172 type sequence E description binding site for residue CO B 504 source : AD1 55) chain B residue 172 type sequence E description binding site for residue CO B 504 source : AD1 56) chain A residue 311 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 57) chain B residue 311 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 192 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 192 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 213 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 61) chain A residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 62) chain A residue 329 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 63) chain B residue 213 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 64) chain B residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 65) chain B residue 329 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3

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