eF-site ID 6ega-AB
PDB Code 6ega
Chain A, B

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Title IRAK4 in complex with a type II inhibitor
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Interleukin-1 receptor-associated kinase 4
Source (IRAK4_HUMAN)
Sequence A:  HSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVNN
TTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSS
DDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGA
ANGINFLHENHHIHRDIKSANILLDEAFTAKISDFVGTTA
YMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREP
QLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVA
SQCLHEKKNKRPDIKKVQQLLQEMTA
B:  RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKG
YVNNTTVAVKKLAALKQQFDQEIKVMAKCQHENLVELLGF
SSDGDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIA
QGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFVG
TTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEH
REPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMY
SVASQCLHEKKNKRPDIKKVQQLLQEMTA
Description


Functional site

1) chain A
residue 192
type
sequence M
description binding site for residue J8A A 501
source : AC1

2) chain A
residue 211
type
sequence A
description binding site for residue J8A A 501
source : AC1

3) chain A
residue 213
type
sequence K
description binding site for residue J8A A 501
source : AC1

4) chain A
residue 233
type
sequence E
description binding site for residue J8A A 501
source : AC1

5) chain A
residue 236
type
sequence V
description binding site for residue J8A A 501
source : AC1

6) chain A
residue 246
type
sequence V
description binding site for residue J8A A 501
source : AC1

7) chain A
residue 262
type
sequence Y
description binding site for residue J8A A 501
source : AC1

8) chain A
residue 263
type
sequence V
description binding site for residue J8A A 501
source : AC1

9) chain A
residue 264
type
sequence Y
description binding site for residue J8A A 501
source : AC1

10) chain A
residue 265
type
sequence M
description binding site for residue J8A A 501
source : AC1

11) chain A
residue 268
type
sequence G
description binding site for residue J8A A 501
source : AC1

12) chain A
residue 302
type
sequence L
description binding site for residue J8A A 501
source : AC1

13) chain A
residue 308
type
sequence I
description binding site for residue J8A A 501
source : AC1

14) chain A
residue 309
type
sequence H
description binding site for residue J8A A 501
source : AC1

15) chain A
residue 318
type
sequence L
description binding site for residue J8A A 501
source : AC1

16) chain A
residue 327
type
sequence I
description binding site for residue J8A A 501
source : AC1

17) chain A
residue 328
type
sequence S
description binding site for residue J8A A 501
source : AC1

18) chain A
residue 329
type
sequence D
description binding site for residue J8A A 501
source : AC1

19) chain A
residue 330
type
sequence F
description binding site for residue J8A A 501
source : AC1

20) chain A
residue 365
type
sequence T
description binding site for residue SO4 A 502
source : AC2

21) chain A
residue 367
type
sequence K
description binding site for residue SO4 A 502
source : AC2

22) chain A
residue 441
type
sequence K
description binding site for residue SO4 A 502
source : AC2

23) chain A
residue 286
type
sequence H
description binding site for residue CO A 503
source : AC3

24) chain A
residue 390
type
sequence H
description binding site for residue CO A 504
source : AC4

25) chain B
residue 408
type
sequence K
description binding site for residue CO A 504
source : AC4

26) chain A
residue 408
type
sequence K
description binding site for residue CO A 505
source : AC5

27) chain B
residue 390
type
sequence H
description binding site for residue CO A 505
source : AC5

28) chain A
residue 306
type
sequence H
description binding site for residue CO A 506
source : AC6

29) chain B
residue 306
type
sequence H
description binding site for residue CO A 506
source : AC6

30) chain B
residue 211
type
sequence A
description binding site for residue J8A B 501
source : AC7

31) chain B
residue 213
type
sequence K
description binding site for residue J8A B 501
source : AC7

32) chain B
residue 233
type
sequence E
description binding site for residue J8A B 501
source : AC7

33) chain B
residue 237
type
sequence M
description binding site for residue J8A B 501
source : AC7

34) chain B
residue 246
type
sequence V
description binding site for residue J8A B 501
source : AC7

35) chain B
residue 262
type
sequence Y
description binding site for residue J8A B 501
source : AC7

36) chain B
residue 263
type
sequence V
description binding site for residue J8A B 501
source : AC7

37) chain B
residue 264
type
sequence Y
description binding site for residue J8A B 501
source : AC7

38) chain B
residue 265
type
sequence M
description binding site for residue J8A B 501
source : AC7

39) chain B
residue 268
type
sequence G
description binding site for residue J8A B 501
source : AC7

40) chain B
residue 308
type
sequence I
description binding site for residue J8A B 501
source : AC7

41) chain B
residue 309
type
sequence H
description binding site for residue J8A B 501
source : AC7

42) chain B
residue 318
type
sequence L
description binding site for residue J8A B 501
source : AC7

43) chain B
residue 327
type
sequence I
description binding site for residue J8A B 501
source : AC7

44) chain B
residue 328
type
sequence S
description binding site for residue J8A B 501
source : AC7

45) chain B
residue 329
type
sequence D
description binding site for residue J8A B 501
source : AC7

46) chain B
residue 330
type
sequence F
description binding site for residue J8A B 501
source : AC7

47) chain B
residue 365
type
sequence T
description binding site for residue SO4 B 502
source : AC8

48) chain B
residue 367
type
sequence K
description binding site for residue SO4 B 502
source : AC8

49) chain B
residue 441
type
sequence K
description binding site for residue SO4 B 502
source : AC8

50) chain B
residue 286
type
sequence H
description binding site for residue CO B 503
source : AC9

51) chain B
residue 286
type
sequence H
description binding site for residue CO B 503
source : AC9

52) chain B
residue 166
type
sequence H
description binding site for residue CO B 504
source : AD1

53) chain B
residue 166
type
sequence H
description binding site for residue CO B 504
source : AD1

54) chain B
residue 172
type
sequence E
description binding site for residue CO B 504
source : AD1

55) chain B
residue 172
type
sequence E
description binding site for residue CO B 504
source : AD1

56) chain A
residue 311
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI1

57) chain B
residue 311
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI1

58) chain A
residue 192
type BINDING
sequence M
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

59) chain B
residue 192
type BINDING
sequence M
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

60) chain A
residue 213
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

61) chain A
residue 313
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

62) chain A
residue 329
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI3

63) chain B
residue 213
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

64) chain B
residue 313
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

65) chain B
residue 329
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI3


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